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Publications of H Frederik Nijhout    :chronological  combined  bibtex listing:

Papers Published

  1. Reed RD, Papa R, Martin A, Hines HM, Counterman BA, Pardo-Diaz C, Jiggins CD, Chamberlain NL, Kronforst MR, Chen R, Halder G, Nijhout HF, McMillan WO, optix Drives the Repeated Convergent Evolution of Butterfly Wing Pattern Mimicry, Science, vol. 333 (August 30, 2011), pp. 1137-1141
  2. Geenen S, du Preez FB, Reed MC, Nijhout HF, Kenna JG, Wilson ID, Westerhoff HV and Snoep JL., A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism., European Journal of Pharmaceutical Sciences, vol. doi:10.1016/j.ejps.2011.08.017 (August, 2011)
  3. Nijhout, HF, Dependence of morphometric allometries on the growth kinetics of body parts, Journal of Theoretical Biology, vol. 288 (August 15, 2011), pp. 35-43
  4. Lawley SD. Cinderella M, Hall MN, Nijhout, HF, Reed MC, Mathematical model insights into arsenic detoxification, Theoretical Biology and Medical Modelling, vol. 8 (August 1, 2011) [doi]
  5. Moczek AP, Sultan S, Foster S, Ledon-Rettig C, Dworkin I, Nijhout HF, Abouheif E, Pfennig DW, The role of developmental plasticity in evolutionary innovation, Proceedings of the Royal Society B-Biological Sciences, vol. 278 (July, 2011), pp. 2705-2713
  6. Neuhouser ML, Nijhout HF, Gregory JF, Reed MC, James SJ, Liu A, Shane B, Ulrich CM, Mathematical modeling predicts the effect of folate deficiency and excess on cancer-related biomarkers, Cancer Epidemiology Biomarkers & Prevention, vol. 20 (July, 2011), pp. 1912-1917
  7. Best J. Nijhout HF. Reed MC, Bursts and the efficacy of selective serotonin reuptake inhibitors, Pharmacopsychiatry, vol. 44 (May, 2011), pp. S76-S83
  8. Callier, VC and Nijhout HF, Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis, PNAS, vol. 108 (2011), pp. 14664-14669
  9. Nijhout HF, Grunert LW, The cellular and physiological mechanism of wing-body scaling in Manduca sexta., Science, vol. 330 (December, 2010), pp. 1693-1695
  10. Tobler A, Nijhout HF, Developmental constraints on the evolution of wing-body allometry in Manduca sexta, Evolution & Development, vol. 12 (November, 2010), pp. 57-66
  11. Nijhout HF, Molecular and physiological basis of colour pattern formation, Advances in Insect Physiology, vol. 38 (August, 2010), pp. 219-265
  12. Best J, Nijhout HF, Reed M, Serotonin synthesis, release and reuptake in terminals: a mathematical model, Theoretical Biology and Medical Modelling, vol. 7 (August, 2010), pp. 34ff
  13. H.F. Nijhout, Photoperiodism in insects: effects on morphology, in Photoperiodism: The Biological Calendar, edited by Nelson RJ, Denlinger DL and Somers DE (August, 2010), pp. 318-341, Oxford University Press
  14. Reed MC, Lieb A, Nijhout HF, The biological significance of substrate inhibition: A mechanism with diverse functions, BioEssays, vol. 32 (May, 2010), pp. 422-429
  15. Tobler A, Nijhout HF, A switch in the control of growth of the wing imaginal disks of Manduca sexta, PLoS-One, vol. 5 no. 5 (May, 2010), pp. e10723
  16. Best J, Reed M, Nijhout HF, Models of Dopaminergic and Serotonergic Signaling, Pharmacopsychiatry, vol. 43 (May, 2010), pp. S61-S66
  17. Diamond SE, Hawkins SD, Nijhout HF, Kingsolver, JG, Evolutionary divergence of field and laboratory populations of Manduca sexta in response to host-plant quality, Ecological Entomology, vol. 35 (April, 2010), pp. 166-174
  18. Nijhout HF, Roff DA, Davidowitz G, Conflicting processes in the evolution of body size and development time, Philosophical Transactions of the Royal Society B-Biological Sciences, vol. 365 (February, 2010), pp. 567-575
  19. Bowsher JH, Nijhout HF, Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba, Development Genes and Evolution, vol. 219 (January, 2010), pp. 577-587
  20. Thomas DC, Conti DV, Baurley J, Nijhout HF, Reed MC, and Ulrich CM., Use of pathway information in molecular epidemiology., Human Genomics, vol. 4 (December, 2009), pp. 21-42
  21. Nijhout HF, Gregory JF, Fitzpatrick C1, Cho E, Lamers KY, Ulrich CM, Reed MC., A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism., Journal of Nutrition, vol. 139 (2009), pp. 784-791
  22. Howell AS, Savage NS, Johnson SA, Bose I, Wagner AW, Zyla TR, Nijhout HF, Reed MC, Goryachev AB and Lew DJ., Singularity in polarization: Rewiring yeast cells to make two buds., Cell, vol. 139 (2009), pp. 731-743
  23. Nijhout HF and Suzuki, Y., Environment and genetic accommodation., Biological Theory, vol. 3 no. 1-9 (2009)
  24. Best JA, Nijhout HF, Reed MC., Homeostatic mechanisms in dopamine synthesis and release: a mathematical model., Theoretical Biology and Medical Modelling, vol. 6:21 (2009)
  25. Reed M, Best J, Nijhout HF., Passive and active stabilization of dopamine in the striatum., Bioscience Hypotheses, vol. 2 (2009), pp. 240-244.
  26. Suzuki Y, Nijhout HF, Constraint and developmental dissociation of phenotypic integration in a genetically accommodated trait, Evolution & Development, vol. 10 (November, 2008), pp. 690-699
  27. Nijhout, HF, Size matters (but so does time), and It's OK to be different, Developmental Cell, vol. 15 (October, 2008), pp. 491-492
  28. Nijhout HF, Reed M, Ulrich C., Mathematical models of one-carbon metabolism, Vitamins and Hormones, vol. 79 (September, 2008), pp. 45-82
  29. Ulrich CM, Reed MC, Nijhout HF, : Modeling folate, one-carbon metabolism, and DNA methylation, Nutrition Reviews, vol. 8 (August, 2008), pp. : S27-S30
  30. Ulrich CM, Neuhouser M, Liu A, Boynton A, Gregory JF, Shane B, James SJ, Reed MC, Nijhout HF., Mathematical modeling of folate metabolism: Predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis, Cancer Epidemiology Biomarkers & Prevention, vol. 17 (July, 2008), pp. 1822-1831
  31. Reed MC, Thomas R, Pavisic J, Nijhout HF, James SJ, Ulrich CM., A mathematical model of glutathione metabolism, Theoretical Biology and Medical Modelling, vol. 5 no. 8 (July, 2008), pp. doi:10.1186/1742-4682-5-8  [abs]
  32. Nijhout, HF, : Developmental phenotypic landscapes, Evolutionary Biology, vol. 35 (June, 2008), pp. 100-103
  33. Suzuki Y, Nijhout HF, Genetic basis of adaptive evolution of a polyphenism by genetic accommodation, Journal of Evolutionary Biology, vol. 21 (January, 2008), pp. 57-66
  34. Nijhout HF, Reed MC, A mathematical model for the regulation of juvenile hormone titers, J. Insect Physiology, vol. 54 (January, 2008), pp. 255-264
  35. Leduc, D., Escartin, F., Nijhout, H.F., Reed, M.C., Liebl, U., Skouloubris, S. and Myllykallio, H., Flavin-dependent thymidylate synthase ThyX activity: Implications for the folate cycle in bacteria., J. Bacteriol., vol. 189 (2007), pp. 8537-8545
  36. Reed R.D., Chen P.H. and Nijhout, H.F., Cryptic variation in butterfly eyespot development: the importance of sample size in gene expression studies, Evolution & Development, vol. 9 (2007), pp. 2-9
  37. Nijhout, H.F, Smith, W.A. Schachar, I, Subramanian, S., Tobler, A. and Grunert, L.W., The control of growth and differentiation of the wing imaginal disks of Manduca sexta., Dev. Biol., vol. 302 (2007), pp. 569-576
  38. Shingleton, A.W., Frankino, W.A., Flatt, T., Nijhout, H.F. and Emlen, D.J., Size and shape: the developmental regulation of static allometry in insects., BioEssays, vol. 29 (2007), pp. 536-548
  39. Brandon, R.N. and Nijhout, H.F., The empirical non-equivalence of genic and genotypic models of selection: A decisive refutation of genic selectionism and pluralistic genic selectionism., Philosophy of Science, vol. 73 (2007), pp. 277-297
  40. Bowsher, J.H. and Nijhout, H.F., Evolution of novel abdominal appendages in a sepsid fly from histoblasts, not imaginal discs., Evolution & Development, vol. 9 (2007), pp. 347-354
  41. Anderson, D., Mattingly, J., Nijhout, H. F., and Reed, M.C., Propagation of fluctuations in biochemical systems, I. Linear SSC networks., . Bull. Math. Biol., vol. 69 (2007), pp. 1791-1813
  42. Suzuki, Y. and Nijhout, H.F, Genetic basis of adaptive evolution of a polyphenism by genetic accommodation., J. Evol. Biol. (in press) (2007)
  43. Nijhout, H.F. and Reed, M.J., A mathematical model for the regulation of juvenile hormone titers., J. Insect Physiol. (in press) (2007)
  44. Nijhout, H.F., Reed, M.C. and Ulrich, C.M., A day in the life of cell metabolism., Biological Theory (in press) (2007)
  45. Suzuki, Y. and Nijhout, H.F., Evolution of a polyphenism by genetic accommodation., Science, vol. 311 (2006), pp. 650-652
  46. Nijhout, H. F., Reed, M., Anderson, D., Mattingly, J., James, S. J., and Ulrich, C. M., Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation rate., Epigenetics, vol. 1 no. 2 (2006), pp. 81-87
  47. Boyles, A.L. Billups, A.V., Deak, K.L., Siegel, D.G., Mehltretter, L., Slifer, S.H. Bassuk, A.G., Kessler, J.A., Reed, M.C. Nijhout, H.F. George, T.M., Enterline, D.S., Gilbert, J.R., Speer, M.C., and the NTD Collaborative Group., Neural tube defects and folate pathway genes: family-based association tests of gene–gene and gene–environment interactions., Environ. Health Perspect., vol. 114 (2006), pp. 1547-1552
  48. Reed, M.C., Nijhout, H.F., Neuhouser, M.L., Gregory J.F. III., Shane, B., James, S.J., Boynton, A. and Ulrich, C.M., A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism., J. Nutr., vol. 136 (2006), pp. 2653-2661
  49. Ulrich , C.M., Nijhout , H.F. and Reed, M.C., Mathematical modeling: epidemiology meets systems biology., Cancer Epidemiol. Biomarkers Prev., vol. 15 (2006), pp. 827-829
  50. Veitia, R. and Nijhout, H.F., The robustness of the transcriptional response to alterations in morphogenetic gradients., BioEssays, vol. 28 (2006), pp. 282-289
  51. Nijhout, H.F., Davidowitz, G. and Roff, D.A., A quantitative analysis of the mechanism that controls body size in Manduca sexta., Journal of Biology, vol. 5 no. 16 (2006), pp. 1-16
  52. H.F. Nijhout, Stochastic gene expression: dominance, thresholds and boundaries., in Dominance and Haploinsufficiency, edited by Veitia, R.A. (2006), pp. 61-75, Landes Press
  53. Nijhout HF, Reed MC, Lam S-L,Shane B, Gregory JF, and Ulrich CM., In silico experimentation with a model of hepatic mitochondrial folate metabolism., Theoretical Biology and Medical Modelling, vol. 3 (2006), pp. 40ff
  54. Davidowitz, G. Roff, D.A. and Nijhout, H.F., A physiological perspective on the response of body size and development time to simultaneous directional selection., Integr. Comp. Biol., vol. 45 (2005), pp. 525-531
  55. B.A.Edgar and H.F. Nijhout, Growth and cell cycle control in Drosophila, in Cell Growth: Control of Cell Size, Cold Spring Harbor Monographs, edited by M.N. Hall, M.Raff and G. Thomas (2004), pp. 23-83, Cold Spring Harbor Laboratory Press
  56. Yang AS, Martin CH, Nijhout HF, Geographic variation of caste structure among ant populations, CURRENT BIOLOGY, vol. 14 (2004), pp. 514-519
  57. Moczek AP, Nijhout HF, Trade-offs during the development of primary and secondary sexual traits in a horned beetle, AMERICAN NATURALIST, vol. 163 (2004), pp. 184-191
  58. Davidowitz G, D'Amico LJ, Nijhout HF, The effects of environmental variation on a mechanism that controls insect body size, EVOLUTIONARY ECOLOGY RESEARCH, vol. 6 (2004), pp. 49-62
  59. H.F. Nijhout, M.C.Reed, P.Budu and C., A mathematical model of the folate cycle: New insights into folate homeostasis, Journal of Biological Chemistry, vol. 279 (2004), pp. 55008-55016
  60. Reed, M.C., Nijhout, H.F., Sparks, R. and Ulrich, N., A mathematical model of the methionine cycle, J. Theoret. Biol., vol. 226 (2004), pp. 33-43
  61. Nijhout, H.F. and G. Davidowitz., Developmental perspectives on phenotypic plasticity, canalization, and fluctuating asymmetry., in Developmental Instability: Causes and Consequences, edited by M. Polak (2003), pp. 3-13, MIT Press
  62. H.F. Nijhout, Polymorphic mimicry in Papilio dardanus: mosaic dominance, big effects and origins., Evolution & Development, vol. 5 (2003), pp. 579-592
  63. Nijhout, H.F., Maini, P.K., Madzvamuse, A., Wathen, A. and Sekimura, T., Pigmentation pattern formation in butterflies --Experiments and models., Comptes Rendus Biologies, vol. 328 (2003), pp. 717-727
  64. Wheeler, D.E. and Nijhout, H.F., A perspective for understanding the modes of juvenile hormone action as a lipid signaling system., BioEssays, vol. 25 (2003), pp. 994-1001
  65. H.F. Nijhout, On the association between genes and complex traits., J. Invest. Dermatol., vol. 8 (2003), pp. 162-163
  66. H.F. Nijhout, The control of body size in insects., Developmental Biology, vol. 261 (2003), pp. 1-9
  67. H.F. Nijhout, The importance of context in genetics, American Scientist, vol. 91 (2003), pp. 416-423
  68. Nijhout, H.F., Berg, A.M. and Gibson, W.T., A mechanistic study of evolvability using the mitogen activated protein kinase cascade., Evolution & Development, vol. 5 (2003), pp. 281-294
  69. Moczek, A.P. and Nijhout, H.F., Rapid evolution of a polyphenic threshold., Evolution & Development, vol. 5 (2003), pp. 259-268
  70. H.F. Nijhout, The development and evolution of adaptive polyphenisms., Evolution & Development, vol. 5 (2003), pp. 9-18
  71. Davidowitz, G., D’Amico. L.J. and H.F. Nijhout., Critical weight in the development of insect body size., Evolution & Development, vol. 5 (2003), pp. 188-197
  72. H.F. Nijhout, The control of growth, Development, vol. 130 (2003), pp. 5863-5867
  73. H.F. Nijhout, Gradients, diffusion and genes in pattern formation, in Origination of Organismal Form, edited by G. Müller and S. Newman, (2003), MIT Press
  74. Koch, P.B. and H.F. Nijhout, The role of wing veins in colour pattern development in the butterfly Papilio xuthus (Lepidoptera: Papilionidae)., European Journal of Entomology, vol. 99 (2002), pp. 67-72
  75. H.F. Nijhout, The nature of robustness in development., BioEssays, vol. 24 (2002), pp. 553-563
  76. H.F. Nijhout, Genetic regulatory networks., in Encyclopedia of Evolution. (2002), Oxford University Press.
  77. Nijhout, H.F. and Grunert, L.W., Bombyxin is a growth factor for wing imaginal disks in Lepidoptera, Proc. Nat. Acad. Sci., vol. 99 (2002), pp. 15446-15450
  78. Nijhout, H.F. and G. Davidowitz., Developmental perspectives on phenotypic plasticity, canalization, and fluctuating asymmetry., in Developmental Instability: Causes and Consequences, edited by M. Polak (2002), Oxford University Press
  79. Moczek, AP and HF Nijhout, Developmental mechanism of threshold evolution in a polyphenic beetle, Evolution & Development, vol. 4 (2002), pp. 252-264
  80. H.F. Nijhout, The ontogeny of phenotypes, in Cycles of Contingency, pp.129-140, edited by S oyama, P Griffiths and R Gray (2001), MIT Press
  81. Moczek, AP and HF Nijhout, A method for sexing third instar larvae of the genus Onthophagus Latreille (Coleoptera Scarabeidae), Coleopt. Bull. (2001)
  82. H.F. Nijhout, Origin of butterfly wing patterns, in The Character Concept in Evolutionary Biology, pp.511-529, edited by GA Wagner (2001), Academic Press
  83. Gilchrist, MA and HF Nijhout, Non-linear developmental processes as sources of dominance, Genetics, vol. 159 (2001), pp. 423-432
  84. Shafiei, M, AP Moczek, and HF Nijhout, Food availability controls the onset of metamorphosis in the dung beetle Onthophagus taurus (Cleoptera: Scarabeidae), Physiol. Entomol, vol. 26 (2001), pp. 173-180
  85. Emlen, DJ and HF Nijhout, Hormonal control of horn length dimorphism in Onthophagus taurus (Coleoptera: Scarabeidae): a second critical period of sensitivity to juvenile hormone, J. Insect Physiol., vol. 47 (2001), pp. 1045-1054
  86. Browder, MH, LJ D'Amico and HF Nijhout, The Role of Low Levels of Juvenile Hormone Esterase in the Metamorphosis of Manduca sexta., J. Insect Science, vol. 1 no. 11 (2001), pp. 1-5
  87. D' Amico, LJ, G Davidowitz and HF Nijhout, The developmental and physiological basis of body size evolution in an insect, Proc. Roy. Soc. London, vol. B 268 (2001), pp. 1589-1593
  88. McDonald, AK and HF Nijhout, The effect of environmental conditions on mating activity of the Buckeye butterfly, Precis coenia, J. Res. Lepidopt., vol. 35 no. 22-28 (2000)
  89. Emlen, DJ and HF Nijhout, The development and evolution of exaggerated morphologies in insects., Ann. Rev. Entomol., vol. 45 (2000), pp. 661-708
  90. Miner, AL, AJ Rosenberg and HF Nijhout, Control of growth and differentiation of the wing imaginal disks of Precis coenia (Lepidoptera: Nymphalidae), J. Insect Physiol., vol. 46 (2000), pp. 251-258

Book Chapters

  1. Best J, Oakley G, Reed MC and Nijhout HF, Mathematical models: Interactions between serotonin and dopamine in Parkinson's Disease., in Etiology and Pathophysiology of Parkinson's Disease., edited by A.Q. Rana, vol. CH. 18 (August, 2011), pp. 405-420, InTech Publ.
  2. Reed MC, Kurtz T and Nijhout HF, Mathematical modeling of cell metabolism., in Encyclopedia of Applied and Computational Mathematics, edited by Engquist, B. (August, 2011), Springer