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Marcy K. Uyenoyama, Professor of Biology

 

Marcy K. Uyenoyama

Marcy Uyenoyama studies mechanisms of evolutionary change at the molecular and population levels. Among the questions under study include the prediction and detection of the effects of natural selection on genomic structure. A major area of research addresses the development of maximum-likelihood and Bayesian methods for inferring evolutionary processes from the pattern of molecular variation. Evolutionary processes currently under study include characterization of population structure across genomes.

Contact Info:
Office Location:  130 Science Drive, Room 137, Duke Box 90338, Durham, NC 27708
Office Phone:  (919) 660-7350
Email Address: send me a message
Web Pages:  http://www.biology.duke.edu/marcylab
http://www.biology.duke.edu/marcylab/

Teaching (Fall 2017):

  • BIOLOGY 660.01, COALESCENCE AND EVOLUTION Synopsis
    Bio Sci 113, TuTh 08:30 AM-09:45 AM
Teaching (Spring 2018):
  • BIOLOGY 250.01, POPULATION GENETICS Synopsis
    Bio Sci 113, TuTh 08:30 AM-09:45 AM

Education:

National Science Foundation National Needs FellowHarvard University1978
Biological Sciences, PhD,Stanford University1978
Ph.D.Stanford University1978
Mathematics, BSStanford University1974
B.S.Stanford University1974

Specialties:

Evolution
Genetics
Genomics
Ecology and Population Biology
Organismal Biology and Behavior

Research Interests: Population genetics, molecular evolution

Marcy Uyenoyama studies mechanisms of evolutionary change at the molecular and population levels. Among the questions under study include the prediction and detection of the effects of natural selection on genomic structure. A major area of research addresses the development of maximum-likelihood and Bayesian methods for inferring evolutionary processes from the pattern of molecular variation. Evolutionary processes currently under study include characterization of population structure across genomes.

Areas of Interest:

molecular evolution
gene genealogy
theoretical population genetics
molecular population genetics
phylogenetics
bioinformatics

Keywords:

3' Untranslated Regions • Adaptation, Physiological • Algorithms • Alleles • Amino Acid Sequence • Analysis of Variance • Angiosperms • Animals • Antigenic Variation • Antigens, Differentiation • Base Sequence • bioinformatics • Biological Evolution • Biometry • Brassica • California • Chromosome Mapping • Cloning, Molecular • Codon • Computer Simulation • Crosses, Genetic • Cytoplasm • Diploidy • DNA Mutational Analysis • DNA Primers • DNA, Complementary • DNA, Plant • Drosophila • Drosophila melanogaster • Epistasis, Genetic • Evolution, Molecular • Extrachromosomal Inheritance • Female • Fertility • Fertilization • Flowers • Fungi • Gene Conversion • Gene Flow • Gene Frequency • gene genealogy • Genes • Genes, Dominant • Genes, Fungal • Genes, Mating Type, Fungal • Genes, Plant • Genes, Recessive • Genetic Drift • Genetic Linkage • Genetic Loci • Genetic Markers • Genetic Speciation • Genetic Variation • Genetics, Population • Genome • Genotype • Gorilla gorilla • Haploidy • Haplotypes • Heterozygote • Heterozygote Detection • Histocompatibility Antigens • Hominidae • Homozygote • Humans • Hybridization, Genetic • Inbreeding • Inheritance Patterns • Intracellular Signaling Peptides and Proteins • Least-Squares Analysis • Likelihood Functions • Linkage Disequilibrium • Litter Size • Major Histocompatibility Complex • Male • Markov Chains • Mathematics • Meiosis • Metagenomics • Mice • Microtubule-Associated Proteins • Models, Biological • Models, Genetic • Models, Statistical • Models, Theoretical • molecular evolution • molecular population genetics • Molecular Sequence Data • Monte Carlo Method • Multigene Family • Mutation • Nuclear Proteins • Numerical Analysis, Computer-Assisted • Pan troglodytes • Pedigree • Peptide Fragments • Periodicals as Topic • Phenotype • phylogenetics • Phylogeny • Plant Physiological Phenomena • Plant Proteins • Plants • Pollen • Polymerase Chain Reaction • Polymorphism, Genetic • Polymorphism, Restriction Fragment Length • Polymorphism, Single Nucleotide • Population Density • Pregnancy • Probability • Protein Kinases • Publishing • Quantitative Trait Loci • Recombination, Genetic • Regression Analysis • Reproduction • Reproduction, Asexual • Reproductive Isolation • Ribonucleases • Rosales • Sample Size • Seeds • Selection, Genetic • Sequence Alignment • Sequence Analysis, DNA • Sequence Homology, Amino Acid • Sex • Sex Ratio • Sibling Relations • Signal Transduction • Software • Solanaceae • Species Specificity • Stochastic Processes • t-Complex Genome Region • theoretical population genetics • Transformation, Genetic • Zygote

Curriculum Vitae

Current Ph.D. Students   (Former Students)

    Postdocs Mentored
    • Naoki Takebayashi (2000/01-2003/07)  
    • Yingqing Lu (1996/10-2000/09)  
    • Judy L. Stone (1995/07-1999/07)  

    Representative Publications   (More Publications)

    1. Fusco, D; Uyenoyama, MK, Sex-specific incompatibility generates locus-specific rates of introgression between species., Genetics, vol. 189 no. 1 (2011), pp. 267-288, ISSN 1943-2631 [21705749], [doi]  [abs]
    2. Fusco, D; Uyenoyama, MK, Effects of polymorphism for locally adapted genes on rates of neutral introgression in structured populations., Theoretical Population Biology, vol. 80 no. 2 (2011), pp. 121-131, ISSN 1096-0325 [21718712], [doi]  [abs]
    3. Seiji Kumagai and Marcy K. Uyenoyama, Heterogeneity in neutral divergence across genomic regions induced by sex-specific hybrid incompatibility, in Evolution in the fast lane: Rapidly evolving genes and genetic systems, edited by Rama S. Singh, Jianping Xu, and Rob J. Kulathinal (2012), pp. 31-39, Oxford University Press
    4. Dutheil, JY; Ganapathy, G; Hobolth, A; Mailund, T; Uyenoyama, MK; Schierup, MH, Ancestral population genomics: the coalescent hidden Markov model approach., Genetics, vol. 183 no. 1 (September, 2009), pp. 259-274 (doi: 10.1534/genetics.109.103010.) [19581452], [doi]  [abs]
    5. Ganapathy, G; Uyenoyama, MK, Site frequency spectra from genomic SNP surveys., Theoretical Population Biology, vol. 75 no. 4 (June, 2009), pp. 346-354 [19371756], [doi]  [abs]
    6. A Hobolth, MK Uyenoyama, C Wiuf, Importance sampling for the infinite sites model., Statistical applications in genetics and molecular biology, vol. 7 no. 1 (2008), pp. Article32, ISSN 1544-6115 [doi]  [abs]
    7. Leman, SC; Chen, Y; Stajich, JE; Noor, MAF; Uyenoyama, MK, Likelihoods from summary statistics: recent divergence between species., Genetics, vol. 171 no. 3 (2005), pp. 1419-1436, ISSN 0016-6731 [16143628], [doi]  [abs]
    8. Takebayashi, N; Newbigin, E; Uyenoyama, MK, Maximum-likelihood estimation of rates of recombination within mating-type regions., Genetics, vol. 167 no. 4 (2004), pp. 2097-2109, ISSN 0016-6731 [15342543], [doi]  [abs]
    9. Vallejo-Marín, M; Uyenoyama, MK, On the evolutionary costs of self-incompatibility: incomplete reproductive compensation due to pollen limitation., Evolution, vol. 58 no. 9 (2004), pp. 1924-1935, ISSN 0014-3820 [15521452]  [abs]
    10. Uyenoyama, MK; Takebayashi, N, A simple method for computing exact probabilities of mutation numbers., Theoretical Population Biology, vol. 65 no. 3 (May, 2004), pp. 271-284, ISSN 0040-5809 [15066423], [doi]  [abs]
    11. Uyenoyama, MK, Genealogy-dependent variation in viability among self-incompatibility genotypes., Theoretical Population Biology, vol. 63 no. 4 (June, 2003), pp. 281-293, ISSN 0040-5809 [12742174]  [abs]
    12. Vallejo-Marín, M; Uyenoyama, MK, On the evolutionary modification of self-incompatibility: Implications of partial clonality for allelic diversity and genealogical structure, in Self-Incompatibility in Flowering Plants: Evolution, Diversity, and Mechanisms, edited by Vernonica Franklin-Tong (2008), pp. 53-71, Springer-Verlag, Tiergartenstr. 17, 69121 Heidelberg, Germany, ISBN 9783540684862 [doi]  [abs]