Publications [#283963] of Piotr E. Marszalek

Papers Published

1. Ke, C; Humeniuk, M; S-Gracz, H; Marszalek, PE, Direct measurements of base stacking interactions in DNA by single-molecule atomic-force spectroscopy., Physical Review Letters, vol. 99 no. 1 (July, 2007), pp. 018302, ISSN 0031-9007 [17678193], [doi]
   (last updated on 2023/06/01)

   Abstract:
   We investigate the elasticity of two types of single-stranded synthetic DNA homopolydeoxynucletides, poly(dA) and poly(dT), by AFM-based single-molecule force spectroscopy. We find that poly(dT) exhibits the expected entropic elasticity behavior, while poly(dA) unexpectedly displays two overstretching transitions in the force-extension relationship. We suggest that these transitions, which occur at approximately 23 pN and approximately 113 pN, directly capture, for the first time, the mechanical signature of base-stacking interactions among adenines in DNA, in the absence of base pairing.