Publications [#243631] of Anita T. Layton

Papers Published

  1. Layton, AT, Mathematical modeling of kidney transport., Wiley Interdisciplinary Reviews: Systems Biology and Medicine, vol. 5 no. 5 (September, 2013), pp. 557-573
    (last updated on 2018/01/19)

    In addition to metabolic waste and toxin excretion, the kidney also plays an indispensable role in regulating the balance of water, electrolytes, nitrogen, and acid-base. In this review, we describe representative mathematical models that have been developed to better understand kidney physiology and pathophysiology, including the regulation of glomerular filtration, the regulation of renal blood flow by means of the tubuloglomerular feedback mechanisms and of the myogenic mechanism, the urine concentrating mechanism, epithelial transport, and regulation of renal oxygen transport. We discuss the extent to which these modeling efforts have expanded our understanding of renal function in both health and disease.