Research Interests for Harold Layton
Research Interests: Mathematical Physiology
Professor Layton is modeling renal function at the
level of the nephron (the functional unit of
the kidney) and at the level of nephron populations. In
particular, he is studying tubuloglomerular feedback (TGF),
the urine concentrating mechanism, and the hemodynamics
of the afferent arteriole. Dynamic models for TGF
and the afferent arteriole involve small systems of semilinear hyperbolic partial
differential equations (PDEs) with timedelays,
and coupled ODES, which are
solved numerically for cases of physiological interest,
or which are linearized for qualitative analytical
investigation.
Dynamic models for the concentrating mechanism involve
large systems of coupled hyperbolic PDEs that describe
tubular convection and epithelial transport. Numerical
solutions of these PDEs help to integrate and interpret
quantities determined by physiologists in many separate
experiments.  Keywords:
 Absorption, Algorithms, Animals, Arterioles, Biological Clocks, Biological Transport, Active, Blood Pressure, Blood Vessels, Body Water, Calcium, Calcium Channels, Capillary Permeability, Cell Membrane Permeability, Cell Size, Compliance, Computer Simulation, Diet, Diffusion, Feedback, Feedback, Physiological, Glomerular Filtration Rate, Hemodynamics, Homeostasis, Humans, Hydrodynamics, Hypertrophy, Ion Transport, Kidney, Kidney Concentrating Ability, Kidney Diseases, Kidney Glomerulus, Kidney Medulla, Kidney Tubules, Kidney Tubules, Collecting, Loop of Henle, Mathematics, Membrane Potentials, Mice, Models, Animal, Models, Biological, Models, Statistical, Models, Theoretical, Muscle, Smooth, Vascular, Nephrons, Nonlinear Dynamics, Osmolar Concentration, Periodicity, Permeability, Potassium, Rats, Rats, Inbred SHR, Signal Transduction, Sodium, Sodium Chloride, Systole, Urea, Urine
 Areas of Interest:
Mathematical models of renal hemodynamics Mathematical models of the urine concentrating mechanism Numerical methods for models of renal systems Countercurrent systems in animals
 Recent Publications
 Layton, AT; Layton, HE, A computational model of epithelial solute and water transport along a human nephron.,
Plos Computational Biology, vol. 15 no. 2
(February, 2019),
pp. e1006108 [doi] [abs]
 Li, Q; McDonough, AA; Layton, HE; Layton, AT, Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis.,
American Journal of Physiology. Renal Physiology, vol. 315 no. 3
(September, 2018),
pp. F692F700 [doi] [abs]
 Sands, JM; Layton, HE, Advances in understanding the urineconcentrating mechanism.,
Annual Review of Physiology, vol. 76
(January, 2014),
pp. 387409, ISSN 00664278 [doi] [abs]
 Sands, JM; Mount, DB; Layton, HE, The physiology of water homeostasis,
in Core Concepts in the Disorders of Fluid, Electrolytes and AcidBase Balance
(November, 2013),
pp. 128, Springer US, ISBN 1461437695 [doi] [abs]
 NievesGonzález, A; Clausen, C; Layton, AT; Layton, HE; Moore, LC, Transport efficiency and workload distribution in a mathematical model of the thick ascending limb.,
American Journal of Physiology. Renal Physiology, vol. 304 no. 6
(March, 2013),
pp. F653F664 [23097466], [doi] [abs]
