Publications [#10383] of Mark Huber

Preprints

1. I. Dinwoodie, A. Dobra, Y. Chen, M. Huber, M. Nicholas, Generating from Hardy-Weinberg proportions , preprint 2002
   (last updated on 2002/12/17)

   Abstract:
   When a population is in equilibrium, the frequency of various alleles at a particular locus appear in what is known as Hardy-Weinberg proportions (HWP). When a finite sample of the population is observed, it is of interest to determine whether or not the population has reached HWP. A Monte Carlo test for this requires the ability to generate samples from a variant of HWP for finite populations. Previous attempts to generate these samples utilized exponentially long algorithms. Here we compare these algorithms against a new technique that requires polynomial time to determine which technique is most useful in practice.