Research Interests for Ioannis Sgouralis

Blood flow autoregulation is an essential factor of proper renal activity. In the microcirculatory level, it is mostly achieved by the afferent arterioles which are vessels capable of adjusting diameter and so of determining blood delivery to the nephrons where the main renal functions take place. In order to regulate blood flow, afferent arterioles respond to signals initiated by two major mechanisms: tubuloglomerular feedback, and the myogenic response. My work focuses on the latter and involves the integration of cellular, vascular, and hemodynamical properties into multi-scale mathematical models that can be used to study the renal autoregulatory process.

Keywords:

renal autoregulation, myogenic response, afferent arteriole, hemodynamics

Areas of Interest:

Biological Modeling
Renal Hemodynamics

Recent Publications

1. Ioannis Sgouralis and Anita T. Layton, Autoregulation and conduction of vasomotor responses in a mathematical model of the rat afferent arteriole, Am J Physiol Renal Physiol (Accepted, 2012) [abs]
2. Jing Chen, Ioannis Sgouralis, Leon C. Moore, Harold E. Layton, and Anita T. Layton, A Mathematical Model of the Myogenic Response to Systolic Pressure in the Afferent Arteriole, Am J Physiol Renal Physiol, vol. 300 (2011), pp. F669-F681 [abs]