Publications [#275592] of Amir H. Rezvani

Papers Published

  1. Levin, ED; Hao, I; Burke, DA; Cauley, M; Hall, BJ; Rezvani, AH (2014). Effects of tobacco smoke constituents, anabasine and anatabine, on memory and attention in female rats. Journal of Psychopharmacology (Oxford, England), 28(10), 915-922.
    (last updated on 2019/05/24)

    © The Author(s) 2014.Nicotine has been well characterized to improve memory and attention. Nicotine is the primary, but not only neuroactive compound in tobacco. O tobacco constituents such as anabasine and anatabine also have agonist actions on nicotinic receptors. The current study investigated the effect anabasine and anatabine on memory and attention. Adult female Sprague-Dawley rats were trained on a win-shift spatial working and reference me task in the 16-arm radial maze or a visual signal detection operant task to test attention. Acute dose-effect functions of anabasine and anata over two orders of magnitude were evaluated for both tasks. In the radial-arm maze memory test, anabasine but not anatabine significantly red the memory impairment caused by the NMDA antagonist dizocilpine (MK-801). In the signal detection attentional task, anatabine but not anaba significantly attenuated the attentional impairment caused by dizocilpine. These studies show that non-nicotine nicotinic agonists in tobacco, sim to nicotine, can significantly improve memory and attentional function. Both anabasine and anatabine produced cognitive improvement, but t effectiveness differed with regard to memory and attention. Follow-up studies with anabasine and anatabine are called for to determine their effi as therapeutics for memory and attentional dysfunction.