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Publications [#275593] of Amir H. Rezvani

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Papers Published

  1. Rezvani, AH; Overstreet, DH (2010). Depressed-like behavior and alcohol drinking are co-morbid but independent in the fawn-hooded rats, 27-38.
    (last updated on 2019/04/21)

    The Fawn-Hooded (FH/Wjd) rat is an inbred strain that exhibits symptoms analogous to those exhibited by human depressives and alcoholics. The exaggerated swim test immobility and increased basal coticosterone levels are two of the depressed-like symptoms; importantly, these symptoms are reduced following chronic antidepressant treatments. Like alcoholics, the FH rat drinks excessive amounts of alcohol voluntarily that if allowed to continue will lead to tolerance and dependence, as revealed by anxiety-like behavior upon withdrawal of the alcohol. The human literature is inconclusive on how these two comorbid conditions are related; however, data in the animals clearly points to them being independent. Genetic studies (F1 and F2 crosses, QTL) indicate no genetic overlap. Chronic treatment with antidepressants selectively reduces the depressed-like symptoms. Thus, the depressed-like behavior and excessive alcohol drinking appear to be independent traits in the FH/Wjd rat. © 2010 Nova Science Publishers, Inc. All rights reserved.

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