Publications [#275605] of Amir H. Rezvani

Papers Published

  1. Morrisett, RA; Rezvani, AH; Overstreet, D; Janowsky, DS; Wilson, WA; Swartzwelder, HS (1990). MK-801 potently inhibits alcohol withdrawal seizures in rats.. European Journal of Pharmacology, 176(1), 103-105.
    (last updated on 2019/05/19)

    The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.