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Research Interests for Roberto Cabeza

Research Interests: Human Memory and Aging

My laboratory investigates the neural correlates of memory and cognition in young and older adults using fMRI. We have three main lines of research: First, we distinguish the neural correlates of various episodic memory processes. For example, we have compared encoding vs. retrieval, item vs. source memory, recall vs. recognition, true vs. false memory, and emotional vs. nonemotional memory. We are particularly interested in the contribution of prefrontal cortex (PFC) and medial temporal lobe (MTL) subregions and their interactions. Second, we investigate similarities and differences between the neural correlates of episodic memory and other memory and cognitive functions (working, semantic, implicit, and procedural memory; attention; perception, etc.). The main goal of this cross-functional approach is to understand the contributions of brain regions shared by different cognitive functions. Finally, in both episodic memory and cross-function studies, we also examine the effects of healthy and pathological aging. Regarding episodic memory, we have linked processes differentially affected by aging (e.g., item vs. source memory, recall vs. recognition) to the effects of aging on specific PFC and MTL subregions. Regarding cross-function comparisons, we identify age-related changes in activity that are common to various functions. For example, we have found an age-related increase in bilaterality that occurs for many functions (memory, attention, language, perception, and motor) and is associated with functional compensation.

Keywords:
Adult, Affect, Age Factors, Aged, Aged, 80 and over, Aging, Amnesia, Amygdala, Apolipoprotein E4, Arousal, Artifacts, Association, Association Learning, Attention, Basal Ganglia, Brain, Brain Injuries, Brain Mapping, Brain-Derived Neurotrophic Factor, Cerebral Cortex, Choice Behavior, Cognition, Cognition Disorders, Corpus Callosum, Corpus Striatum, Decision Making, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Electroencephalography, Emotions, Entorhinal Cortex, Episodic memory, Executive Function, Frontal Lobe, Functional Laterality, Functional Neuroimaging, Hemodynamics, Hippocampus, Human Development, Imaging, Three-Dimensional, Individuality, Judgment, Language Tests, Learning, Magnetic Resonance Imaging, Memory, Memory Disorders, Memory, Episodic, Memory, Long-Term, Memory, Short-Term, Mental Processes, Mental Recall, Models, Neurological, Multivariate Analysis, Neuroimaging, Neuropsychological Tests, Neurosciences, Occipital Lobe, Parahippocampal Gyrus, Parietal Lobe, Prefrontal Cortex, Psychological Tests, Psychophysiology, Recognition (Psychology), Regression Analysis, Reward, Signal Detection, Psychological, Statistics, Nonparametric, Temporal Lobe, Verbal Learning, Visual Cortex, Visual Perception, Vocabulary, Word Association Tests, Young Adult
Representative Publications   (search)
  1. St Jacques, PL; Dolcos, F; Cabeza, R, Effects of aging on functional connectivity of the amygdala for subsequent memory of negative pictures: a network analysis of functional magnetic resonance imaging data., Psychological Science, vol. 20 no. 1 (January, 2009), pp. 74-84 [19152542], [doi[abs].
  2. Davis, SW; Dennis, NA; Buchler, NG; White, LE; Madden, DJ; Cabeza, R, Assessing the effects of age on long white matter tracts using diffusion tensor tractography., Neuroimage, vol. 46 no. 2 (June, 2009), pp. 530-541 [19385018], [doi[abs].
  3. Cabeza, R; Ciaramelli, E; Olson, IR; Moscovitch, M, The parietal cortex and episodic memory: an attentional account., Nature Reviews. Neuroscience, vol. 9 no. 8 (2008), pp. 613-625 [18641668], [doi[abs].
  4. Dennis, NA; Hayes, SM; Prince, SE; Madden, DJ; Huettel, SA; Cabeza, R, Effects of aging on the neural correlates of successful item and source memory encoding., Journal of Experimental Psychology. Learning, Memory, and Cognition, vol. 34 no. 4 (2008), pp. 791-808 [18605869], [doi[abs].
  5. Dennis, NA; Kim, H; Cabeza, R, Age-related differences in brain activity during true and false memory retrieval., Journal of Cognitive Neuroscience, vol. 20 no. 8 (2008), pp. 1390-1402 [18303982], [doi[abs].
  6. St Jacques, P; Rubin, DC; LaBar, KS; Cabeza, R, The short and long of it: neural correlates of temporal-order memory for autobiographical events., Journal of Cognitive Neuroscience, vol. 20 no. 7 (2008), pp. 1327-1341 [18284345], [doi[abs].
  7. Davis, SW; Dennis, NA; Daselaar, SM; Fleck, MS; Cabeza, R, Que PASA? The posterior-anterior shift in aging., Cerebral Cortex (New York, N.Y. : 1991), vol. 18 no. 5 (2008), pp. 1201-1209 [17925295], [doi[abs].
  8. Daselaar, SM; Rice, HJ; Greenberg, DL; Cabeza, R; LaBar, KS; Rubin, DC, The spatiotemporal dynamics of autobiographical memory: neural correlates of recall, emotional intensity, and reliving., Cerebral Cortex (New York, N.Y. : 1991), vol. 18 no. 1 (2008), pp. 217-229 [17548799], [doi[abs].
  9. Ritchey, M; Dolcos, F; Cabeza, R, Role of amygdala connectivity in the persistence of emotional memories over time: an event-related FMRI investigation., Cerebral Cortex (New York, N.Y. : 1991), vol. 18 no. 11 (2008), pp. 2494-2504 [18375529], [doi[abs].
  10. Kim, H; Cabeza, R, Trusting our memories: dissociating the neural correlates of confidence in veridical versus illusory memories., Journal of Neuroscience, vol. 27 no. 45 (November, 2007), pp. 12190-12197 [17989285], [doi[abs].
  11. Kim, H; Cabeza, R, Differential contributions of prefrontal, medial temporal, and sensory-perceptual regions to true and false memory formation., Cerebral Cortex (New York, N.Y. : 1991), vol. 17 no. 9 (September, 2007), pp. 2143-2150 [17110592], [doi[abs].
  12. Prince, SE; Tsukiura, T; Cabeza, R, Distinguishing the neural correlates of episodic memory encoding and semantic memory retrieval., Psychological Science, vol. 18 no. 2 (February, 2007), pp. 144-151 [17425535], [doi[abs].
  13. Dennis, NA; Daselaar, S; Cabeza, R, Effects of aging on transient and sustained successful memory encoding activity., Neurobiology of Aging, vol. 28 no. 11 (November, 2007), pp. 1749-1758 [16919850], [doi[abs].
  14. Cabeza, R; St Jacques, P, Functional neuroimaging of autobiographical memory., Trends in Cognitive Sciences, vol. 11 no. 5 (May, 2007), pp. 219-227 [17382578], [doi[abs].

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