Publications [#254688] of Myron L. Wolbarsht

Journal Articles

1. Pakalnis, VA; Rustgi, AK; Stefansson, E; Wolbarsht, ML; Landers, MB (1987). The effect of timolol on anterior-chamber oxygenation.. Annals of ophthalmology, 19(8), 298-300. [3662313]
   (last updated on 2018/09/26)

   Abstract:
   The effect of timolol maleate, a nonspecific beta-blocking agent, on anterior-segment oxygenation was studied using oxygen-sensitive microelectrodes inserted into the mid-anterior chamber of 13 cat eyes. The anterior-chamber oxygen tension was monitored continuously for two hours following the topical application of three drops of timolol 0.5%. Although a small, but significant, decline in oxygen tension of 19% was observed over the initial 90 minutes (P less than or equal to .05), the overall 10% decrease at the end of two hours was not considered either clinically or statistically significant when compared with a group of controls. Timolol, since it does not contribute significantly to hypoxia, may therefore be a more prudent choice for lowering intraocular pressure in disorders where hypoxia is believed to play an important role, such as in neovascular glaucoma and sickle-cell hyphema.