Research Interests for David J. Madden

Research Interests:

My research foucses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from more general effects arising from a slowing in elementary perceptual processes. The cognitive abilities of interest include selective attention as measured in visual search tasks, semantic and episodic memory retrieval, and executive control processes. The behavioral measures are necessary to define the cognitive abilities of interest, and the neuroimaging techniques help define the functional neuroanatomy of those abilities. The PET and fMRI measures provide information regarding neural activity during cognitive performance. DTI is a recently developed technique that images the structural integrity of white matter. The white matter tracts of the brain provide critical pathways linking the gray matter regions, and thus this work will complement the studies using PET and fMRI that focus on gray matter activation. A current focus of the research program is the functional connectivity among regions, not only during cognitive task performance but also during rest. These latter measures, referred to as intrinsic functional connectivity, are beginning to show promise as an index of overall brain functional efficiency, which can be assessed without the implementation of a specific cognitive task. From DTI, information can be obtained regarding how anatomical connectivity constrains intrinsic functional connectivity. It will be important to determine the relative influence of white matter pathway integrity, intrinsic functional connectivity, and task-related functional connectivity, as mediators of age-related differences in behavioral measures of cognitive performance. Ultimately, the research program can help link age-related changes in cognitive performance to changes in the structure and function of specific neural systems. The results also have implications for clinical translation, in terms of the identification of neural biomarkers for the diagnosis of neural pathology and targeting rehabilitation procedures.

Keywords:
aging, Aging, attention, Attention, Brain, Brain Chemistry, brain imaging, Brain Mapping, Cerebral Cortex, cognition, Cognition, Diffusion Tensor Imaging, Executive Function, Functional Neuroimaging, Learning, Magnetic Phenomena, Magnetic Resonance Imaging, Memory, Muser Mentor, Nerve Fibers, Myelinated, Neural Pathways, Pattern Recognition, Visual, Perception, Visual Perception
Representative Publications   (search)
  1. Madden, DJ; Bennett, IJ; Burzynska, A; Potter, GG; Chen, N-K; Song, AW, Diffusion tensor imaging of cerebral white matter integrity in cognitive aging., Biochim Biophys Acta, vol. 1822 no. 3 (March, 2012), pp. 386-400 [21871957], [doi] [abs].
  2. Madden, DJ; Langley, LK, Age-related changes in selective attention and perceptual load during visual search., Psychol Aging, vol. 18 no. 1 (March, 2003), pp. 54-67 [12641312], [doi] [abs].
  3. Davis, SW; Kragel, JE; Madden, DJ; Cabeza, R, The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity., Cereb Cortex, vol. 22 no. 1 (January, 2012), pp. 232-242 [21653286], [doi] [abs].
  4. Whiting, WL; Madden, DJ; Langley, LK; Denny, LL; Turkington, TG; Provenzale, JM; Hawk, TC; Coleman, RE, Lexical and sublexical components of age-related changes in neural activation during visual word identification., J Cogn Neurosci, vol. 15 no. 3 (April, 2003), pp. 475-487 [12729497], [doi] [abs].
  5. Bennett, IJ; Madden, DJ; Vaidya, CJ; Howard, JH; Howard, DV, White matter integrity correlates of implicit sequence learning in healthy aging., Neurobiol Aging, vol. 32 no. 12 (December, 2011), pp. 2317.e1-2317.12 [20452099], [doi] [abs].
  6. Madden DJ, Langley LK, Denny LL, Turkington TG, Provenzale JM, Hawk TC & Coleman RE, Adult age differences in visual word identification: functional neuroanatomy by positron emission tomography, Brain Cogn., vol. 49 no. 3 (August, 2002), pp. 297-321.
  7. Madden, DJ; Costello, MC; Dennis, NA; Davis, SW; Shepler, AM; Spaniol, J; Bucur, B; Cabeza, R, Adult age differences in functional connectivity during executive control., Neuroimage, vol. 52 no. 2 (August, 2010), pp. 643-657, ACADEMIC PRESS INC ELSEVIER SCIENCE [20434565], [doi] [abs].
  8. Madden, DJ; Turkington, TG; Provenzale, JM; Denny, LL; Langley, LK; Hawk, TC; Coleman, RE, Aging and attentional guidance during visual search: functional neuroanatomy by positron emission tomography., Psychol Aging, vol. 17 no. 1 (March, 2002), pp. 24-43 [11931285], [doi] [abs].
  9. Biswal, BB; Mennes, M; Zuo, X-N; Gohel, S; Kelly, C; Smith, SM; Beckmann, CF; Adelstein, JS; Buckner, RL; Colcombe, S; Dogonowski, A-M; Ernst, M; Fair, D; Hampson, M; Hoptman, MJ; Hyde, JS; Kiviniemi, VJ; Kötter, R; Li, S-J; Lin, C-P; Lowe, MJ; Mackay, C; Madden, DJ; Madsen, KH; Margulies, DS; Mayberg, HS; McMahon, K; Monk, CS; Mostofsky, SH; Nagel, BJ; Pekar, JJ; Peltier, SJ; Petersen, SE; Riedl, V; Rombouts, SARB; Rypma, B; Schlaggar, BL; Schmidt, S; Seidler, RD; Siegle, GJ; Sorg, C; Teng, G-J; Veijola, J; Villringer, A; Walter, M; Wang, L; Weng, X-C; Whitfield-Gabrieli, S; Williamson, P; Windischberger, C; Zang, Y-F; Zhang, H-Y; Castellanos, FX; Milham, MP, Toward discovery science of human brain function., Proc Natl Acad Sci U S A, vol. 107 no. 10 (March, 2010), pp. 4734-4739 [20176931], [doi] [abs].
  10. Madden, DJ, Speed and timing of behavioral processes, in Handbook of the psychology of aging, 5th, edited by J. E. Birren & K. W. Schaie (2001), pp. 288-312, San Diego: Academic Press.
  11. Madden, DJ; Bennett, IJ; Song, AW, Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging., Neuropsychol Rev, vol. 19 no. 4 (December, 2009), pp. 415-435 [19705281], [doi] [abs].
  12. Madden, DJ; Gottlob, LR, Adult age differences in strategic and dynamic components of focusing visual attention, Aging, Neuropsychology, and Cognition, vol. 4 no. 3 (January, 1997), pp. 185-210, Informa UK Limited [doi] [abs].
  13. Chen, N-K; Chou, Y-H; Song, AW; Madden, DJ, Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity., Brain Struct Funct, vol. 213 no. 6 (October, 2009), pp. 571-585 [19727810], [doi] [abs].
  14. Madden, DJ; Turkington, TG; Provenzale, JM; Hawk, TC; Hoffman, JM; Coleman, RE, Selective and divided visual attention: age-related changes in regional cerebral blood flow measured by H2(15)O PET., Hum Brain Mapp, vol. 5 no. 6 (1997), pp. 389-409 [20408243], [doi] [abs].
  15. Madden, DJ; Spaniol, J; Costello, MC; Bucur, B; White, LE; Cabeza, R; Davis, SW; Dennis, NA; Provenzale, JM; Huettel, SA, Cerebral white matter integrity mediates adult age differences in cognitive performance., J Cogn Neurosci, vol. 21 no. 2 (February, 2009), pp. 289-302 [18564054], [doi] [abs].
  16. Madden, DJ; Spaniol, J; Bucur, B; Whiting, WL, Age-related increase in top-down activation of visual features., Q J Exp Psychol (Hove), vol. 60 no. 5 (May, 2007), pp. 644-651 [17455072], [doi] [abs].
  17. Madden, DJ; Spaniol, J; Whiting, WL; Bucur, B; Provenzale, JM; Cabeza, R; White, LE; Huettel, SA, Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study., Neurobiol Aging, vol. 28 no. 3 (March, 2007), pp. 459-476 [16500004], [doi] [abs].
  18. Spaniol, J; Madden, DJ; Voss, A, A diffusion model analysis of adult age differences in episodic and semantic long-term memory retrieval., J Exp Psychol Learn Mem Cogn, vol. 32 no. 1 (January, 2006), pp. 101-117 [16478344], [doi] [abs].
  19. Bucur, B; Madden, DJ; Allen, PA, Age-related differences in the processing of redundant visual dimensions., Psychol Aging, vol. 20 no. 3 (September, 2005), pp. 435-446 [16248703], [doi] [abs].
  20. Madden, DJ; Whiting, WL; Spaniol, J; Bucur, B, Adult age differences in the implicit and explicit components of top-down attentional guidance during visual search., Psychol Aging, vol. 20 no. 2 (June, 2005), pp. 317-329 [16029095], [doi] [abs].
  21. Whiting, WL; Madden, DJ; Pierce, TW; Allen, PA, Searching from the top down: ageing and attentional guidance during singleton detection., Q J Exp Psychol A, vol. 58 no. 1 (January, 2005), pp. 72-97 [15881292], [doi] [abs].
  22. Madden, DJ; Whiting, WL; Cabeza, R; Huettel, SA, Age-related preservation of top-down attentional guidance during visual search., Psychol Aging, vol. 19 no. 2 (June, 2004), pp. 304-309 [15222823], [doi] [abs].
  23. Madden, DJ; Whiting, WL; Huettel, SA; White, LE; MacFall, JR; Provenzale, JM, Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time., Neuroimage, vol. 21 no. 3 (March, 2004), pp. 1174-1181 [15006684], [doi] [abs].
  24. Madden, DJ; Whiting, WL; Provenzale, JM; Huettel, SA, Age-related changes in neural activity during visual target detection measured by fMRI., Cereb Cortex, vol. 14 no. 2 (February, 2004), pp. 143-155 [14704211], [doi] [abs].
  25. Madden, D. J. (2001). Speed and timing of behavioral processes. In J. E. Birren & K. W. Schaie (Eds.), Handbook of the psychology of aging (5th ed., pp. 288-312). San Diego: Academic Press. .