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Publications [#274374] of Edward D. Levin

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Papers Published

  1. Rose, JE; Levin, ED; Behm, FM; Adivi, C; Schur, C (1990). Transdermal nicotine facilitates smoking cessation.. Clinical Pharmacology and Therapeutics, 47(3), 323-330. [2178852], [doi]
    (last updated on 2019/12/07)

    The efficacy of a transdermal nicotine patch in facilitation of smoking cessation was evaluated in a randomized double-blind trial. Sixty-five smokers who were highly dependent on cigarettes participated in the study, which included a behavioral smoking-cessation program. The rates of continuous abstinence were significantly higher in the nicotine group both initially (55% versus 34%) and at 3 weeks (18% versus 6%). Certain smoking withdrawal symptoms, including negative affect and hypoarousal, were effectively relieved by the nicotine patch. There was a trend toward a reduction in cigarette craving, whereas hunger and habit withdrawal symptoms were not affected. The main side effect associated with the nicotine patch was skin irritation. These findings suggest that a nicotine skin patch may be a useful aid to smoking cessation; however, the combination of other techniques with nicotine replacement may provide a more effective treatment for symptoms such as craving for cigarettes.

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