| Publications [#276532] of Harry S. Swartzwelder
search PubMed.Journal Articles
- Guo-Ross, SX; Jones, KH; Shetty, AK; Wilson, WA; Swartzwelder, HS (2003). Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat.. Neurosci Lett, 341(2), 161-163. [12686390], [doi]
(last updated on 2024/04/23)
Abstract: The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring.
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