| Publications [#358785] of Harry S. Swartzwelder
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- Robinson, DL; Amodeo, LR; Chandler, LJ; Crews, FT; Ehlers, CL; Gómez-A, A; Healey, KL; Kuhn, CM; Macht, VA; Marshall, SA; Swartzwelder, HS; Varlinskaya, EI; Werner, DF "The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents.." International Review of Neurobiology. 2021: 305-340. [doi]
(last updated on 2024/03/28)
Abstract: Alcohol drinking is often initiated during adolescence, and this frequently escalates to binge drinking. As adolescence is also a period of dynamic neurodevelopment, preclinical evidence has highlighted that some of the consequences of binge drinking can be long lasting with deficits persisting into adulthood in a variety of cognitive-behavioral tasks. However, while the majority of preclinical work to date has been performed in male rodents, the rapid increase in binge drinking in adolescent female humans has re-emphasized the importance of addressing alcohol effects in the context of sex as a biological variable. Here we review several of the consequences of adolescent ethanol exposure in light of sex as a critical biological variable. While some alcohol-induced outcomes, such as non-social approach/avoidance behavior and sleep disruption, are generally consistent across sex, others are variable across sex, such as alcohol drinking, sensitivity to ethanol, social anxiety-like behavior, and induction of proinflammatory markers.
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