Psychology and Neuroscience Faculty Database
Psychology and Neuroscience
Arts & Sciences
Duke University

 HOME > Arts & Sciences > pn > Faculty    Search Help Login pdf version printable version 

Publications [#276067] of Ilene C. Siegler

search PubMed.

Journal Articles

  1. Haberstick, BC; Lessem, JM; Hewitt, JK; Smolen, A; Hopfer, CJ; Halpern, CT; Killeya-Jones, LA; Boardman, JD; Tabor, J; Siegler, IC; Williams, RB; Mullan Harris, K (2014). MAOA genotype, childhood maltreatment, and their interaction in the etiology of adult antisocial behaviors.. Biol Psychiatry, 75(1), 25-30. [23726513], [doi]
    (last updated on 2024/01/01)

    Abstract:
    BACKGROUND: Maltreatment by an adult or caregiver during childhood is a prevalent and important predictor of antisocial behaviors in adulthood. A functional promoter polymorphism in the monoamine oxidase A (MAOA) gene has been implicated as a moderating factor in the relationship between childhood maltreatment and antisocial behaviors. Although there have been numerous attempts at replicating this observation, results remain inconclusive. METHODS: We examined this gene-environment interaction hypothesis in a sample of 3356 white and 960 black men (aged 24-34) participating in the National Longitudinal Study of Adolescent Health. RESULTS: Primary analysis indicated that childhood maltreatment was a significant risk factor for later behaviors that violate rules and the rights of others (p < .05), there were no main effects of MAOA genotype, and MAOA genotype was not a significant moderator of the relationship between maltreatment and antisocial behaviors in our white sample. Post hoc analyses identified a similar pattern of results among our black sample in which maltreatment was not a significant predictor of antisocial behavior. Post hoc analyses also revealed a main effect of MAOA genotype on having a disposition toward violence in both samples and for violent convictions among our black sample. None of these post hoc findings, however, survived correction for multiple testing (p > .05). Power analyses indicated that these results were not due to insufficient statistical power. CONCLUSIONS: We could not confirm the hypothesis that MAOA genotype moderates the relationship between childhood maltreatment and adult antisocial behaviors.


Duke University * Arts & Sciences * Faculty * Staff * Grad * Postdocs * Reload * Login