Publications [#251928] of Jean Hamilton

Journal Articles

  1. Insel, TR; Hamilton, JA; Guttmacher, LB; Murphy, DL (1983). D-amphetamine in obsessive-compulsive disorder. Psychopharmacology, 80(3), 231-235.
    (last updated on 2022/01/27)

    In a double-blind crossover study, single doses of d-amphetamine and placebo were administered to 12 patients with severe chronic obsessive-compulsive disorder (OCD). Improvement of obsessional symptoms was significant on clinical ratings and was correlated with improved performance on an attention task. Changes were also significant for self-rated measures of activation and altered reality. The behavior response to amphetamine was not statistically correlated with subsequent improvement during a 6-week clomipramine trial, although the direction of change was the same during both treatments for every patient studied.