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Warren H. Meck, Professor of Psychology and Neuroscience and Faculty Network Member of Duke Institute for Brain Sciences

Warren H. Meck

Research Summary:
Research interests include the neuroanatomical and neuropharmacological basis of timing and time perception in the seconds-to-minutes range. This work relates to the striatal beat-frequency theory of interval timing as well as mode-control models of temporal integration and attentional time-sharing in humans and other animals. Current work focuses on the use of genomic and ensemble-recording techniques designed to identify the basic properties of interval timing and decision making in cortical-striatal circuits. Additional work utilizes neuroimaging techniques (e.g., EEG & fMRI) to examine temporal processing deficits in selected clinical populations. Another major focus for our research uses animal models to study developmental periods of dietary choline sensitivity that provide an ontogenetic mechanism for regulating memory capacity and precision in adulthood. This work includes the study of prenatal choline effects on sleep-dependent memory consolidation processes in adult rats and mice as well as inoculation against age-related impairments in spatial and temporal cognition.

Specialties:

Systems and Integrative Neuroscience

Representative Publications:   (More Publications)   (search)

  1. CV Buhusi and WH Meck (2009). Relative time sharing: new findings and an extension of the resource allocation model of temporal processing.. Philos Trans R Soc Lond B Biol Sci, 364(1525), 1875-1885. [19487190], [doi]  [abs]
  2. CV Buhusi and WH Meck (2009). Relativity theory and time perception: single or multiple clocks?. PLoS One, 4(7), e6268. [19623247], [doi]  [abs]
  3. R-K Cheng, CL Williams and WH Meck (2009). Neurophysiological Mechanisms of Sleep-Dependent Memory Consolidation and Its Facilitation by Prenatal Choline Supplementation. CHINESE JOURNAL OF PHYSIOLOGY, 52(4), 223-235. [Gateway.cgi], [doi]
  4. C Fortin, S Fairhurst, C Malapani, C Morin, J Towey and WH Meck (2009). Expectancy in humans in multisecond peak-interval timing with gaps.. Atten Percept Psychophys, 71(4), 789-802. [19429959], [doi]  [abs]
  5. CJ MacDonald, WH Meck, SA Simon and MA Nicolelis (2009). Taste-guided decisions differentially engage neuronal ensembles across gustatory cortices.. J Neurosci, 29(36), 11271-11282. [19741134], [doi]  [abs]
  6. EM Brannon, ME Libertus, WH Meck and MG Woldorff (2008). Electrophysiological measures of time processing in infant and adult brains: Weber's Law holds.. J Cogn Neurosci, 20(2), 193-203. [18275328], [doi]  [abs]
  7. RK Cheng, CL Williams and WH Meck (2008). Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation.. Brain Res, 1237, 176-194. [18793620], [doi]  [abs]
  8. WH Meck, TB Penney and V Pouthas (2008). Cortico-striatal representation of time in animals and humans.. Curr Opin Neurobiol, 18(2), 145-152. [18708142], [doi]  [abs]
  9. WH Meck, CL Williams, JM Cermak and JK Blusztajn (2007). Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia.. Front Integr Neurosci, 1, 7. (doi:10.3389/neuro.07.007.2007). [18958235], [doi]  [abs]
  10. TB Penney, J Gibbon and WH Meck (2008). Categorical scaling of duration bisection in pigeons (Columba livia), mice (Mus musculus), and humans (homo sapiens). Psychological Science, 19(11), 1102-1108. [19076481], [doi]  [abs]
  11. S Droit-Volet and WH Meck (2007). How emotions colour our perception of time.. Trends Cogn Sci, 11(12), 504-513. [18023604], [doi]  [abs]
  12. CV Buhusi and WH Meck (2005). What makes us tick? Functional and neural mechanisms of interval timing.. Nat Rev Neurosci, 6(10), 755-765. [16163383], [doi]  [abs]

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