Professor PhD, Brown University, 1982 mailing address: Center for Behavioral Neuroscience and Genomics
3010 GSRB 2, Duke University
572 Research Drive
Durham, NC 27708 email: phone: 919-660-5765
Research Summary: Research interests include the neuroanatomical and neuropharmacological basis of spatial and temporal memory with special reference to factors determining content, clarity, capacity and hierachical structure. Additional interests in chronobiology include mode-control models of temporal integration as related to counting and timing behavior in both rats and humans. Current work focuses on using fMRI to examine temporal processing in normal human subjects and clinical populations, and using dietary alterations of nutrients such as choline to permanently alter memory capacity and precision in rats and mice.
Buhusi, C. V., & Meck, W. H (2006). Interval timing with gaps and distracters: Evaluation of the ambiguity, switch, and time-sharing hypotheses. Journal of Experimental Psychology: Animal Behavior Processes, 32, 329-338.
Cheng, R. K., MacDonald, C. J., & Meck, W. H (2006). Differential effects of cocaine and ketamine on time estimation: Implications for neurobiological models of interval timing. Pharmacology Biochemistry and Behavior, 85, 114-122.
Cheng, R. K., Meck, W. H., & Williams, C. L (2006). α7 nicotinic acetylcholine receptors and temporal memory: Synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock. Learning & Memory, 13, 127-134.
MacDonald, C. J., & Meck, W. H (2006). Interaction of raclopride and preparatory-interval effects on simple reaction-time performance. Behavioural Brain Research, 175, 62-74.
Matell, M. S., Bateson, M., & Meck, W. H (2006). Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions. Psychopharmacology, 188, 201-212.
Meck, W. H (2006). Neuroanatomical localization of an internal clock: A functional link between mesolimbic, nigrostriatal, and mesocortical dopaminergic systems. Brain Research, 1108, 93-107.
Buhusi, C. V., & Meck, W. H (2005).
What makes us tick? Functional and neural mechanisms of interval timing. Nature Neuroscience Reviews, 6, 755-765.
Lustig, C., Matell, M. S., & Meck, W. H (2005).
Not “just” a coincidence: Frontal-striatal synchronization in working memory and interval timing. Memory, 13, 441-448.
MacDonald, C. J., & Meck, W. H (2005).
Differential effects of clozapine and haloperidol on interval timing in the supraseconds range. Psychopharmacology, 182, 232-244.
Meck, W. H (2005).
Neuropsychology of timing and time perception. Brain and Cognition, 58, 1-8.
Penney, T. B., Meck, W. H., Roberts, S. A., Gibbon, J., & Erlenmeyer-Kimling, L (2005).
Attention mediated temporal processing deficits in subjects at high risk for schizophrenia. Brain and Cognition, 58, 109-118.
Brannon, E., Wolfe, L., Meck, W. H., & Woldorff, M (2004). Timing in the baby brain. Cognitive Brain Research, 21, 227-233.
Hinton, S. C., & Meck, W. H (2004). Frontal-striatal circuitry activated by human peak-interval timing in the supra-seconds range. Cognitive Brain Research, 21, 171-182.
MacDonald, C. J., & Meck, W. H (2004). Systems-level integration of interval timing and reaction time. Neuroscience and Biobehavioral Reviews, 28, 747-769.
Matell, M. S., & Meck, W. H (2004). Cortico-striatal circuits and interval timing: Coincidence-detection of oscillatory processes. Cognitive Brain Research, 21, 139-170.
Meck, W. H., & Malapani, C (2004). Neuroimaging of interval timing. Cognitive Brain Research, 21, 133-137.
Matell, M. S., Meck, W. H., & Nicolelis, M. A. L (2003).
Interval timing and the encoding of signal duration by ensembles of cortical and striatal neurons. Behavioral Neuroscience, 117, 760-773.
Meck, W. H., & Williams, C. L (2003).
Metabolic imprinting of choline by its availability during gestation: Implications for memory and attentional processing across the lifespan. Neuroscience and Biobehavioral Reviews, 27, 385-399.
Buhusi, C. V., & Meck, W. H (2002). Differential effects of methamphetamine and haloperidol on the control of an internal clock. Behavioral Neuroscience, 116, 291-297.
Meck, W. H. & Benson, A. M (2002). Dissecting the brain's internal clock: How frontal-striatal circuitry keeps time and shifts attention. Brain and Cognition, 48, 195-211.
