Publications [#114976] of Miguel A Nicolelis
Papers Published
- JK Chapin, KA Moxon, RS Markowitz, MA Nicolelis (1999). Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex.. Nature neuroscience, UNITED STATES, 2(7), 664-70.
(last updated on 2004/01/12)Abstract:
To determine whether simultaneously recorded motor cortex neurons can be used for real-time device control, rats were trained to position a robot arm to obtain water by pressing a lever. Mathematical transformations, including neural networks, converted multineuron signals into 'neuronal population functions' that accurately predicted lever trajectory. Next, these functions were electronically converted into real-time signals for robot arm control. After switching to this 'neurorobotic' mode, 4 of 6 animals (those with > 25 task-related neurons) routinely used these brain-derived signals to position the robot arm and obtain water. With continued training in neurorobotic mode, the animals' lever movement diminished or stopped. These results suggest a possible means for movement restoration in paralysis patients.