Publications [#277222] of Redford B. Williams

Journal Articles

1. Roy, A; Bissette, G; Williams, R; Berman, J; Gonzalez, B (2003). CSF CRH in abstinent cocaine-dependent patients.. Psychiatry Research, 117(3), 277-280. [doi]
   (last updated on 2023/06/01)

   Abstract:
   Alterations in stress responsivity may be important in the vulnerability to become cocaine dependent. Thus, an index of hypothalamic-pituitary-adrenal (HPA) axis function was examined in abstinent cocaine-dependent patients. Cerebrospinal fluid (CSF) concentrations of corticotropin releasing factor (CRH) were determined in 29 abstinent cocaine-dependent patients and 66 normal controls. The results showed that there was no significant difference between the abstinent cocaine-dependent patients and normal controls for CSF CRH. Also, CSF CRH concentrations were not related to cocaine-craving scores in a cue-elicited cocaine-craving procedure. Thus, these data suggest that after protracted abstinence from cocaine there is no marked dysregulation of CRH systems as measured by CSF CRH concentrations.