Publications [#277366] of Redford B. Williams

Journal Articles

  1. Jiang, R; Brummett, BH; Babyak, MA; Siegler, IC; Williams, RB (2013). Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms.. Journal of Psychiatric Research, 47(2), 233-239.
    (last updated on 2019/05/19)

    Abstract:
    BDNF Val66Met by chronic stress interaction has been studied using childhood stress as a moderator, but has not been widely studied using chronic stress in adulthood.Two independent samples were used: Duke-CG (238 Caucasians) and MESA (5524 Caucasians, African Americans and Hispanics). Chronic stress in Duke-CG was operationalized as having primary caregiving responsibility for a spouse or relative with diagnosed Alzheimer's disease or other major dementia; chronic stress in MESA was defined using chronic burden score constructed from self-reported problems of health (self and someone close), job, finance and relationships. CES-D scale was the measure of depression in both samples. The BDNF Val66Met by adulthood chronic stress interaction predicting CES-D was examined using linear regression, adjusted for covariates.The main effect of BDNF Val66Met genotype on CES-D scores was non-significant (ps > 0.607) but the adulthood chronic stress indicator was significant (ps < 0.001) in both samples. The BDNF Val66Met genotype by adulthood chronic stress interaction was also significant (ps < 0.039) in both samples. The impact of chronic stress in adulthood on CES-D scores was significantly larger in Val/Val genotype individuals than Met carriers.We found in two independent samples that depression levels increased significantly more as a function of adulthood chronic stress Val/Val genotype carriers than Met carriers. Individuals with the Val/Val genotype and chronic stress exposure could be targeted for interventions designed to reduce risk of depression if this finding is confirmed in future studies.