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Publications [#277384] of Redford B. Williams

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Journal Articles

  1. Lamprecht, F; Eichelman, B; Thoa, NB; Williams, RB; Kopin, IJ (1972). Rat fighting behavior: Serum dopamine-β-hydroxylase and hypothalamic tyrosine hydroxylase. Science (New York, N.Y.), 177(4055), 1214-1215.
    (last updated on 2019/04/23)

    Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shock-induced fighting, in the activity of serum dopamine-β-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine-β-hydroxylase activity returned to normal; it therefore appears that long-term stress may increase central catecholamine synthesis, possibly resulting in a persistent increase in aggressive behavior.

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