Publications [#277384] of Redford B. Williams

Journal Articles

1. Lamprecht, F; Eichelman, B; Thoa, NB; Williams, RB; Kopin, IJ (1972). Rat fighting behavior: serum dopamine- -hydroxylase and hypothalamic tyrosine hydroxylase.. Science (New York, N.Y.), 177(4055), 1214-1215.
   (last updated on 2023/06/01)

   Abstract:
   Male Sprague-Dawley rats were subjected to 4 weeks of daily periods of immobilization stress. One of two experimental groups was allowed 1 month of recovery. After 4 weeks of stress, there was a significant increase in shockinduced fighting, in the activity of serum dopamine-beta-hydroxylase, and in the activity of hypothalamic tyrosine hydroxylase. The concentration of hypothalamic norepinephrine was not decreased. After 4 weeks of recovery, only serum dopamine-betahydroxylase activity returned to normal; it therefore appears that longterm stress may increase central catecholamine synthesis. possibly resulting in a persistent increase in aggressive behavior.