Publications [#273466] of Richard S. Keefe

Journal Articles

1. Kraus, MS; Keefe, RSE; Krishnan, RKR (2009). Memory-prediction errors and their consequences in schizophrenia.. Neuropsychol Rev, 19(3), 336-352.
   (last updated on 2024/01/01)

   Abstract:
   Cognitive deficits play a central role in the onset of schizophrenia. Cognitive impairment precedes the onset of psychosis in at least a subgroup of patients, and accounts for considerable dysfunction. Yet cognitive deficits as currently measured are not significantly related to hallucinations and delusions. Part of this counterintuitive absence of a relationship may be caused by the lack of an organizing principle of cognitive impairment in schizophrenia research. We review literature suggesting that a system of memory-based prediction is central to human perception, thought and action , and forward the notion that many of the symptoms of schizophrenia are a result of a failure of this system.