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Publications [#273485] of Richard S. Keefe

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Journal Articles

  1. Konneker, TI; Crowley, JJ; Quackenbush, CR; Keefe, RSE; Perkins, DO; Stroup, TS; Lieberman, JA; Oord, EVD; Sullivan, PF (2010). No association of the serotonin transporter polymorphisms 5-HTTLPR and rs25531 with schizophrenia or neurocognition. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 153(5), 1115-1117. [doi]
    (last updated on 2019/04/19)

    Apromoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry-informative principal components as covariates, the effect of 5-HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868-1.172, P = 0.91). In cases only, 5-HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5-HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons. © 2010 Wiley-Liss, Inc.

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