Psychology and Neuroscience Faculty Database
Psychology and Neuroscience
Arts & Sciences
Duke University

 HOME > Arts & Sciences > pn > Faculty    Search Help Login pdf version printable version 

Publications [#273531] of Richard S. Keefe

search PubMed.

Journal Articles

  1. Davidson, M; Keefe, RSE; Mohs, RC; Siever, LJ; Losonczy, MF; Horvath, TB; Davis, KL (1987). L-Dopa challenge and relapse in schizophrenia. The American Journal of Psychiatry, 144(7), 934-938.
    (last updated on 2019/04/19)

    Abstract:
    Neuroleptic administration has been shown to be superior to placebo in prolonging schizophrenic remission. However, individual patients are able to maintain long periods of remission in the absence of neuroleptic treatment, while others relapse soon after neuroleptic withdrawal. This study attempted to predict time to relapse in 28 schizophrenic patients withdrawn from neuroleptics and challenged with L-dopa for 7 days, then followed until relapse. Time to relapse correlated significantly with L-dopa-induced increase in BPRS score (p = .006). Five of six patients who responded to L-dopa relapsed within 4 weeks after L-dopa administration, while only four of 22 who did not respond relapsed in a comparable period.


Duke University * Arts & Sciences * Faculty * Staff * Grad * Postdocs * Reload * Login