Psychology and Neuroscience Faculty Database
Psychology and Neuroscience
Arts & Sciences
Duke University

 HOME > Arts & Sciences > pn > Faculty    Search Help Login pdf version printable version 

Publications [#254594] of Christina L. Williams

search PubMed.

Journal Articles

  1. Sandstrom, NJ; Loy, R; Williams, CL (2002). Prenatal choline supplementation increases NGF levels in the hippocampus and frontal cortex of young and adult rats. Brain Research, 947(1), 9-16. [doi]
    (last updated on 2018/07/16)

    Abstract:
    Female Sprague-Dawley rats received ∼300 mg/kg per day of choline chloride through their drinking water on days 11 of pregnancy through birth and the level of nerve growth factor (NGF) in the hippocampus and frontal cortex of their male offspring was measured at 20 and 90 days of age. Prenatal choline supplementation caused significant increases in hippocampal NGF levels at 20 and 90 days of age, while levels of NGF in the frontal cortex were elevated in choline-supplemented rats at 20 days of age, but not 90 days of age. These results suggest that increases in NGF levels during development or adulthood may be one mechanism underlying improvements in spatial and temporal memory of adult rats exposed to elevated levels of choline chloride perinatally. © 2002 Elsevier Science B.V. All rights reserved.


Duke University * Arts & Sciences * Faculty * Staff * Grad * Postdocs * Reload * Login