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| Publications [#45191] of Ruey-Kuang Cheng
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- *Cheng, R. K., & Liao, R. M. (September, 1999).
Dopamine and timing behavior: Effects of d-amphetamine, SCH23390, and raclopride. (Poster at the Annual Meeting of Chinese
Psychological Association, Taipei, Taiwan).
(last updated on 2006/11/23)
Abstract:
Recent research suggests that dopamine has an
important role in the animal timing behavior.
The present study examined the effects of
dopamine agonist and antagonists on the
Differential Reinforcement of Low-rate
responses 10 seconds (DRL10) operant
behavior. Rats were trained on DRL10 and
were tested 60 minutes after IP drug
injection. In addition to analyzing DRL10
responses, we measured the inter-response
interval (IRT) distribution. Under the
treatment of d-amphetamine (0.5, 1.0 mg/kg),
the IRT distribution horizontally shift to
the left which indicated the subject tended
to press the lever quicker than that under
saline control. Accordingly, d-amphetamine
increased the non-reinforced responses and
decreased the reinforced-responses of DRL10
behavior. These results suggest that the
d-amphetamine accelerates the timing system
of the rat under DRL10 responding. Under the
treatment of SCH23390 (0.05, 0.1 mg/kg) and
raclopride (0.2, 0.4 mg/kg), high dose of
both drugs significantly impaired the DRL10
behavior by decreasing both reinforced and
non-reinforced responses. These results
showed that the timing component of DRL10
behavior was disrupted by dopamine receptor
blockade on either D1 or D2 subtypes.
Together, the function of dopamine systems
can be highly involved in the timing behavior
as the DRL10 operant task used in the present
work.
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