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Publications [#339747] of Sarah Arthur

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Journal Articles

  1. Shelby, RA; Dorfman, CS; Bosworth, HB; Keefe, F; Sutton, L; Owen, L; Corsino, L; Erkanli, A; Reed, SD; Arthur, SS; Somers, T; Barrett, N; Huettel, S; Gonzalez, JM; Kimmick, G (2019). Testing a behavioral intervention to improve adherence to adjuvant endocrine therapy (AET).. Contemp Clin Trials, 76, 120-131. [doi]
    (last updated on 2020/10/27)

    Adjuvant endocrine therapy (AET) is used to prevent recurrence and reduce mortality for women with hormone receptor positive breast cancer. Poor adherence to AET is a significant problem and contributes to increased medical costs and mortality. A variety of problematic symptoms associated with AET are related to non-adherence and early discontinuation of treatment. The goal of this study is to test a novel, telephone-based coping skills training that teaches patients adherence skills and techniques for coping with problematic symptoms (CST-AET). Adherence to AET will be assessed in real-time for 18 months using wireless smart pill bottles. Symptom interference (i.e., pain, vasomotor symptoms, sleep problems, vaginal dryness) and cost-effectiveness of the intervention protocol will be examined as secondary outcomes. Participants (N = 400) will be recruited from a tertiary care medical center or community clinics in medically underserved or rural areas. Participants will be randomized to receive CST-AET or a general health education intervention (comparison condition). CST-AET includes ten nurse-delivered calls delivered over 6 months. CST-AET provides systematic training in coping skills for managing symptoms that interfere with adherence. Interactive voice messaging provides reinforcement for skills use and adherence that is tailored based on real-time adherence data from the wireless smart pill bottles. Given the high rates of non-adherence and recent recommendations that women remain on AET for 10 years, we describe a timely trial. If effective, the CST-AET protocol may not only reduce the burden of AET use but also lead to cost-effective changes in clinical care and improve breast cancer outcomes. Trials registration:, NCT02707471, registered 3/3/2016.

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