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Publications [#328106] of Zachary A. Monge

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Journal Articles

  1. Madden, DJ; Parks, EL; Tallman, CW; Boylan, MA; Hoagey, DA; Cocjin, SB; Packard, LE; Johnson, MA; Chou, Y-H; Potter, GG; Chen, N-K; Siciliano, RE; Monge, ZA; Honig, JA; Diaz, MT (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.. Neurobiology of Aging, 54, 199-213. [doi]
    (last updated on 2018/12/18)

    Abstract:
    Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.


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