Elizabeth R. Hauser, Associate Professor of Medicine and Statistical Science, and Director of The Center for Human Genetics

Contact Info:

595 LaSalle Street

(919) 684-0603, (919) 684-2063

elizabeth.hauser@duke.edu

Personal Web Page:

http://wwwchg.mc.duke.edu/faculty/ehauser.html

Education:

Ph.D., University of Michigan, 1998

Research Interests:

linkage analysis, genetic association, gene mapping, genetic epidemiology, statistical genetics, biostatistics, cardiovascular disease, diabetes, aging, prenatal genetics, kidney disease

Representative Publications   (More Publications)

1. L Wang, ER Hauser, SH Shah, D Seo, P Sivashanmugam, ST Exum, SG Gregory, CB Granger, JL Haines, CJ Jones, D Crossman, C Haynes, WE Kraus, NJ Freedman, MA Pericak-Vance, PJ Goldschmidt-Clermont, JM Vance. "Polymorphisms of the Tumor Suppressor Gene LSAMP are Associated with Left Main Coronary Artery Disease.." Annals of human genetics (March, 2008).  [abs]
2. SH Shah, ER Hauser, D Crosslin, L Wang, C Haynes, J Connelly, S Nelson, J Johnson, S Gadson, CL Nelson, D Seo, S Gregory, WE Kraus, CB Granger, P Goldschmidt-Clermont, LK Newby. "ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention.." Atherosclerosis (February, 2008).  [abs]
3. BS Sutton, DR Crosslin, SH Shah, SC Nelson, A Bassil, AB Hale, C Haynes, PJ Goldschmidt-Clermont, JM Vance, WE Kraus, SG Gregory, ER Hauser. "Comprehensive Genetic Analysis of the Platelet Activating Factor Acetylhydrolase (PLA2G7) Gene and Cardiovascular Disease in Case/Control and Family Datasets.." Hum Mol Genet (January, 2008).  [abs]
4. S Schmidt, MA Schmidt, X Qin, ER Martin, ER Hauser. "Increased efficiency of case-control association analysis by using allele-sharing and covariate information.." Human heredity, Switzerland 65.3 (2008): 154-65.  [abs]
5. S Schmidt, X Qin, MA Schmidt, ER Martin, ER Hauser. "Interpreting analyses of continuous covariates in affected sibling pair linkage studies.." Genetic epidemiology, United States 31.6 (September, 2007): 541-52.  [abs]
6. L Wang, ER Hauser, SH Shah, MA Pericak-Vance, C Haynes, D Crosslin, M Harris, S Nelson, AB Hale, CB Granger, JL Haines, CJ Jones, D Crossman, D Seo, SG Gregory, WE Kraus, PJ Goldschmidt-Clermont, JM Vance. "Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease.." American journal of human genetics, United States 80.4 (April, 2007): 650-63.  [abs]
7. RH Chung, ER Hauser, ER Martin. "Interpretation of simultaneous linkage and family-based association tests in genome screens.." Genetic epidemiology, United States 31.2 (February, 2007): 134-42.  [abs]
8. AP Murtha, T Sinclair, ER Hauser, GK Swamy, WN Herbert, RP Heine. "Maternal serum cytokines in preterm premature rupture of membranes.." Obstetrics and gynecology, United States 109.1 (January, 2007): 121-7.  [abs]
9. AP Murtha, A Nieves, ER Hauser, GK Swamy, BA Yonish, TR Sinclair, RP Heine. "Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth.." American journal of obstetrics and gynecology, United States 195.5 (November, 2006): 1249-53.  [abs]
10. SH Shah, WE Kraus, DC Crossman, CB Granger, JL Haines, CJ Jones, V Mooser, L Huang, C Haynes, E Dowdy, GL Vega, SM Grundy, JM Vance, ER Hauser. "Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q.." Annals of human genetics, England 70.Pt 6 (November, 2006): 738-48.  [abs]
11. JJ Connelly, T Wang, JE Cox, C Haynes, L Wang, SH Shah, DR Crosslin, AB Hale, S Nelson, DC Crossman, CB Granger, JL Haines, CJ Jones, JM Vance, PJ Goldschmidt-Clermont, WE Kraus, ER Hauser, SG Gregory. "GATA2 is associated with familial early-onset coronary artery disease.." PLoS genetics, United States 2.8 (August, 2006): e139.  [abs]
12. S Schmidt, MA Schmidt, X Qin, ER Martin, ER Hauser. "Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis.." Genetic epidemiology, United States 30.5 (July, 2006): 409-22.  [abs]
13. RH Chung, ER Hauser, ER Martin. "The APL test: extension to general nuclear families and haplotypes and examination of its robustness.." Human heredity, Switzerland 61.4 (2006): 189-99.  [abs]
14. E Rampersaud, WK Scott, ER Hauser, MC Speer. "Potential for expanded power in linkage studies using the ALLEGRO and MERLIN software programs.." Journal of medical genetics, England 42.12 (December, 2005): e68.  [abs]
15. SH Shah, MA Schmidt, H Mei, WK Scott, ER Hauser, S Schmidt. "Searching for epistatic interactions in nuclear families using conditional linkage analysis.." BMC Genet 6 Suppl 1 (December, 2005): S148.  [abs]
16. H Xu, SG Gregory, ER Hauser, JE Stenger, MA Pericak-Vance, JM Vance, S Züchner, MA Hauser. "SNPselector: a web tool for selecting SNPs for genetic association studies.." Bioinformatics (Oxford, England), England 21.22 (November, 2005): 4181-6.  [abs]
17. RR Allingham, JL Wiggs, ER Hauser, KR Larocque-Abramson, C Santiago-Turla, B Broomer, EA Del Bono, FL Graham, JL Haines, MA Pericak-Vance, MA Hauser. "Early adult-onset POAG linked to 15q11-13 using ordered subset analysis.." Investigative ophthalmology & visual science, United States 46.6 (June, 2005): 2002-5.  [abs]
18. M Schmidt, ER Hauser, ER Martin, S Schmidt. "Extension of the SIMLA package for generating pedigrees with complex inheritance patterns: environmental covariates, gene-gene and gene-environment interaction.." Statistical applications in genetics and molecular biology, United States 4 (2005): Article15.  [abs]
19. AL Boyles, WK Scott, ER Martin, S Schmidt, YJ Li, A Ashley-Koch, MP Bass, M Schmidt, MA Pericak-Vance, MC Speer, ER Hauser. "Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing.." Human heredity, Switzerland 59.4 (2005): 220-7.  [abs]
20. "Schmidt M, Hauser ER, Martin ER, Schmidt S. Extension of the SIMLA Package for Generating Pedigrees with Complex Inheritance Patterns: Environmental Covariates, Gene-Gene and Gene-Environment Interaction. Stat Appl Genet Mol Biol. 2005;4(1):nihms3139.." ().
21. JE Stenger, H Xu, C Haynes, ER Hauser, M Pericak-Vance, PJ Goldschmidt-Clermont, JM Vance. "Statistical Viewer: a tool to upload and integrate linkage and association data as plots displayed within the Ensembl genome browser.." BMC bioinformatics, England 6 (2005): 95.  [abs]
22. ER Hauser, DC Crossman, CB Granger, JL Haines, CJ Jones, V Mooser, B McAdam, BR Winkelmann, AH Wiseman, JB Muhlestein, AG Bartel, CA Dennis, E Dowdy, S Estabrooks, K Eggleston, S Francis, K Roche, PW Clevenger, L Huang, B Pedersen, S Shah, S Schmidt, C Haynes, S West, D Asper, M Booze, S Sharma, S Sundseth, L Middleton, AD Roses, MA Hauser, JM Vance, MA Pericak-Vance, WE Kraus. "A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study.." American journal of human genetics, United States 75.3 (September, 2004): 436-47.  [abs]
23. ER Hauser, RM Watanabe, WL Duren, MP Bass, CD Langefeld, M Boehnke. "Ordered subset analysis in genetic linkage mapping of complex traits.." Genetic epidemiology, United States 27.1 (July, 2004): 53-63.  [abs]
24. S Schmidt, WK Scott, EA Postel, A Agarwal, ER Hauser, MA De La Paz, JR Gilbert, DE Weeks, MB Gorin, JL Haines, MA Pericak-Vance. "Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12.." BMC genetics, England 5 (July, 2004): 18.  [abs]
25. K Silander, LJ Scott, TT Valle, KL Mohlke, HM Stringham, KR Wiles, WL Duren, KF Doheny, EW Pugh, P Chines, N Narisu, PP White, TE Fingerlin, AU Jackson, C Li, S Ghosh, VL Magnuson, K Colby, MR Erdos, JE Hill, P Hollstein, KM Humphreys, RA Kasad, J Lambert, KN Lazaridis, G Lin, A Morales-Mena, K Patzkowski, C Pfahl, R Porter, D Rha, L Segal, YD Suh, J Tovar, A Unni, C Welch, JA Douglas, MP Epstein, ER Hauser, W Hagopian, TA Buchanan, RM Watanabe, RN Bergman, J Tuomilehto, FS Collins, M Boehnke, Finland-United Staaates Investigation of NIDDM Genetics (FUSION). "A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14.." Diabetes, United States 53.3 (March, 2004): 821-9.  [abs]
26. MP Bass, ER Martin, ER Hauser. "Pedigree generation for analysis of genetic linkage and association.." Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, Singapore (2004): 93-103.  [abs]
27. ER Hauser, AS Allen. "Where the rubber meets the road in pharmacogenetics: assessment of gene-environment interactions.." American heart journal, United States 146.6 (December, 2003): 929-31.
28. ER Martin, MP Bass, ER Hauser, NL Kaplan. "Accounting for linkage in family-based tests of association with missing parental genotypes.." American journal of human genetics, United States 73.5 (November, 2003): 1016-26.  [abs]
29. ER Martin, MP Bass, JR Gilbert, MA Pericak-Vance, ER Hauser. "Genotype-based association test for general pedigrees: the genotype-PDT.." Genetic epidemiology, United States 25.3 (November, 2003): 203-13.  [abs]
30. WK Scott, ER Hauser, DE Schmechel, KA Welsh-Bohmer, GW Small, AD Roses, AM Saunders, JR Gilbert, JM Vance, JL Haines, MA Pericak-Vance. "Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22.." American journal of human genetics, United States 73.5 (November, 2003): 1041-51.  [abs]
31. ML Markert, M Sarzotti, DA Ozaki, GD Sempowski, ME Rhein, LP Hale, F Le Deist, MJ Alexieff, J Li, ER Hauser, BF Haynes, HE Rice, MA Skinner, SM Mahaffey, J Jaggers, LD Stein, MR Mill. "Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients.." Blood, United States 102.3 (August, 2003): 1121-30.  [abs]
32. ER Hauser, V Mooser, DC Crossman, JL Haines, CH Jones, BR Winkelmann, S Schmidt, WK Scott, AD Roses, MA Pericak-Vance, CB Granger, WE Kraus, Design of the Genetics of Early Onset Cardiovascular Disease study. "Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study.." American heart journal, United States 145.4 (April, 2003): 602-13.  [abs]
33. Y Shao, ML Cuccaro, ER Hauser, KL Raiford, MM Menold, CM Wolpert, SA Ravan, L Elston, K Decena, SL Donnelly, RK Abramson, HH Wright, GR DeLong, JR Gilbert, MA Pericak-Vance. "Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes.." American journal of human genetics, United States 72.3 (March, 2003): 539-48.  [abs]
34. E Rampersaud, A Allen, YJ Li, Y Shao, M Bass, C Haynes, A Ashley-Koch, ER Martin, S Schmidt, ER Hauser. "Adjusting for covariates on a slippery slope: linkage analysis of change over time.." BMC genetics, England 4 Suppl 1 (2003): S50.  [abs]
35. ER Hauser, FC Hsu, D Daley, JM Olson, E Rampersaud, JP Lin, AD Paterson, LM Poisson, GA Chase, G Dahmen, A Ziegler. "Effects of covariates: a summary of Group 5 contributions.." Genetic epidemiology, United States 25 Suppl 1 (2003): S43-9.  [abs]
36. WE Kraus, ER Hauser. "Angiotensin-converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: identifying the guideposts for navigating the genetics landscape.." American heart journal, United States 144.5 (November, 2002): 747-9.
37. "Lebel-Hardenack S, Hauser ER, Law TF, Schmidt J and Grant SR. (2002) Mapping of sex determination loci on the White Campion (Silene latifolia) Y chromosome using AFLP. Genetics, 160: 717-725." ().
38. "Hauser ER. Unit 1.2 Pedigree Selection and Information Content. In: Current Protocols in Human Genetics. Pericak-Vance MA, Haines JA (eds). J. Wiley and Sons, New York. 2001.." ().
39. S Schmidt, Y Shao, ER Hauser, SH Slifer, ER Martin, WK Scott, MC Speer, MA Pericak-Vance. "Life after the screen: making sense of many P-values.." Genetic epidemiology, United States 21 Suppl 1 (2001): S546-51.  [abs]
40. S Ghosh, RM Watanabe, TT Valle, ER Hauser, VL Magnuson, CD Langefeld, DS Ally, KL Mohlke, K Silander, K Kohtamäki, P Chines, J Balow Jr, G Birznieks, J Chang, W Eldridge, MR Erdos, ZE Karanjawala, JI Knapp, K Kudelko, C Martin, A Morales-Mena, A Musick, T Musick, C Pfahl, R Porter, JB Rayman. "The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes.." American journal of human genetics, UNITED STATES 67.5 (November, 2000): 1174-85.  [abs]
41. RM Watanabe, S Ghosh, CD Langefeld, TT Valle, ER Hauser, VL Magnuson, KL Mohlke, K Silander, DS Ally, P Chines, J Blaschak-Harvan, JA Douglas, WL Duren, MP Epstein, TE Fingerlin, HS Kaleta, EM Lange, C Li, RC McEachin, HM Stringham, E Trager, PP White, J Balow Jr, G Birznieks, J Chang, W Eldridge. "The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.." American journal of human genetics, UNITED STATES 67.5 (November, 2000): 1186-200.  [abs]
42. ER Hauser, MA Pericak-Vance. "Genetic analysis for common complex disease.." American heart journal, UNITED STATES 140.4 (October, 2000): S36-44.
43. MP Bass, MM Menold, CM Wolpert, SL Donnelly, SA Ravan, ER Hauser, LO Maddox, JM Vance, RK Abramson, HH Wright, JR Gilbert, ML Cuccaro, GR DeLong, MA Pericak-Vance. "Genetic studies in autistic disorder and chromosome 15.." Neurogenetics, ENGLAND 2.4 (March, 2000): 219-26.  [abs]
44. R Jacksch, TM Schiele, W Knobloch, R Niehues, ER Hauser, K Massalha. "[Carotid stenting with the new slotted tube stent--prospective multicenter study. Essen experiences]]." Zeitschrift für Kardiologie, Germany 89 Suppl 8 (2000): 40-6.  [abs]
45. RM Watanabe, T Valle, ER Hauser, S Ghosh, J Eriksson, K Kohtamäki, C Ehnholm, J Tuomilehto, FS Collins, RN Bergman, M Boehnke. "Familiality of quantitative metabolic traits in Finnish families with non-insulin-dependent diabetes mellitus. Finland-United States Investigation of NIDDM Genetics (FUSION) Study investigators.." Human heredity, SWITZERLAND 49.3 (June, 1999): 159-68.  [abs]
46. S Ghosh, RM Watanabe, ER Hauser, T Valle, VL Magnuson, MR Erdos, CD Langefeld, J Balow, DS Ally, K Kohtamaki, P Chines, G Birznieks, HS Kaleta, A Musick, C Te, J Tannenbaum, W Eldridge, S Shapiro, C Martin, A Witt, A So, J Chang, B Shurtleff, R Porter, K Kudelko, A Unni, L Segal, R Sharaf, J Blaschak-Harvan, J Eriksson, T Tenkula, G Vidgren, C Ehnholm, E Tuomilehto-Wolf, W Hagopian, TA Buchanan, J Tuomilehto, RN Bergman, FS Collins, M Boehnke. "Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.." Proceedings of the National Academy of Sciences of the United States of America, UNITED STATES 96.5 (March, 1999): 2198-203.  [abs]
47. S Ghosh, CD Langefeld, D Ally, RM Watanabe, ER Hauser, VL Magnuson, SJ Nylund, T Valle, J Eriksson, RN Bergman, J Tuomilehto, FS Collins, M Boehnke. "The W64R variant of the beta3-adrenergic receptor is not associated with type II diabetes or obesity in a large Finnish sample.." Diabetologia, GERMANY 42.2 (February, 1999): 238-44.  [abs]
48. JL Anderson, ER Hauser, ER Martin, WK Scott, A Ashley-Koch, KJ Kim, SA Monks, CS Haynes, MC Speer, MA Pericak-Vance. "Complete genomic screen for disease susceptibility loci in nuclear families.." Genetic epidemiology, UNITED STATES 17 Suppl 1 (1999): S473-8.  [abs]
49. ER Hauser, M Boehnke. "Genetic linkage analysis of complex genetic traits by using affected sibling pairs.." Biometrics, UNITED STATES 54.4 (December, 1998): 1238-46.  [abs]
50. S Ghosh, ER Hauser, VL Magnuson, T Valle, DS Ally, ZE Karanjawala, JB Rayman, JI Knapp, A Musick, J Tannenbaum, C Te, W Eldridge, S Shapiro, T Musick, C Martin, A So, A Witt, JB Harvan, RM Watanabe, W Hagopian, J Eriksson, SJ Nylund, K Kohtamaki, E Tuomilehto-Wolf, M Boehnke. "A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.." The Journal of clinical investigation, UNITED STATES 102.4 (August, 1998): 704-9.  [abs]
51. T Valle, J Tuomilehto, RN Bergman, S Ghosh, ER Hauser, J Eriksson, SJ Nylund, K Kohtamäki, L Toivanen, G Vidgren, E Tuomilehto-Wolf, C Ehnholm, J Blaschak, CD Langefeld, RM Watanabe, V Magnuson, DS Ally, WA Hagopian, E Ross, TA Buchanan, F Collins, M Boehnke. "Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study.." Diabetes care, UNITED STATES 21.6 (June, 1998): 949-58.  [abs]
52. S Ghosh, ZE Karanjawala, ER Hauser, D Ally, JI Knapp, JB Rayman, A Musick, J Tannenbaum, C Te, S Shapiro, W Eldridge, T Musick, C Martin, JR Smith, JD Carpten, MJ Brownstein, JI Powell, R Whiten, P Chines, SJ Nylund, VL Magnuson, M Boehnke, FS Collins. "Methods for precise sizing, automated binning of alleles, and reduction of error rates in large-scale genotyping using fluorescently labeled dinucleotide markers. FUSION (Finland-U.S. Investigation of NIDDM Genetics) Study Group.." Genome research, UNITED STATES 7.2 (February, 1997): 165-78.  [abs]
53. JE Richards, PR Lichter, S Herman, ER Hauser, YC Hou, AT Johnson, M Boehnke. "Probable exclusion of GLC1A as a candidate glaucoma gene in a family with middle-age-onset primary open-angle glaucoma.." Ophthalmology, UNITED STATES 103.7 (July, 1996): 1035-40.  [abs]
54. ER Hauser, M Boehnke, SW Guo, N Risch. "Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations.." Genetic epidemiology, UNITED STATES 13.2 (1996): 117-37.  [abs]
55. FJ Couch, J Garber, S Kiousis, K Calzone, ER Hauser, SD Merajver, TS Frank, M Boehnke, JS Chamberlain, FS Collins. "Genetic analysis of eight breast-ovarian cancer families with suspected BRCA1 mutations.." Journal of the National Cancer Institute. Monographs, UNITED STATES 17 (1995): 9-14.  [abs]
56. JS Chamberlain, M Boehnke, TS Frank, S Kiousis, J Xu, SW Guo, ER Hauser, RA Norum, EA Helmbold, DS Markel. "BRCA1 maps proximal to D17S579 on chromosome 17q21 by genetic analysis.." American journal of human genetics, UNITED STATES 52.4 (April, 1993): 792-8.  [abs]
57. NE Maestri, ER Hauser, D Bartholomew, SW Brusilow. "Prospective treatment of urea cycle disorders.." The Journal of pediatrics, UNITED STATES 119.6 (December, 1991): 923-8.  [abs]
58. JE Finkelstein, ER Hauser, CO Leonard, SW Brusilow. "Late-onset ornithine transcarbamylase deficiency in male patients.." The Journal of pediatrics, UNITED STATES 117.6 (December, 1990): 897-902.  [abs]
59. ER Hauser, JE Finkelstein, D Valle, SW Brusilow. "Allopurinol-induced orotidinuria. A test for mutations at the ornithine carbamoyltransferase locus in women.." The New England journal of medicine, UNITED STATES 322.23 (June, 1990): 1641-5.  [abs]
60. PH Arn, ER Hauser, GH Thomas, G Herman, D Hess, SW Brusilow. "Hyperammonemia in women with a mutation at the ornithine carbamoyltransferase locus. A cause of postpartum coma.." The New England journal of medicine, UNITED STATES 322.23 (June, 1990): 1652-5.

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