Publications [#337345] of Merlise Clyde
Papers Published
- Day, DB; Clyde, MA; Xiang, J; Li, F; Cui, X; Mo, J; Gong, J; Weschler, CJ; Zhang, Y; Zhang, JJ. "Age modification of ozone associations with cardiovascular disease risk in adults: a potential role for soluble P-selectin and blood pressure.." Journal of thoracic disease 10.7 (July, 2018): 4643-4652. [doi]
(last updated on 2024/04/24)Abstract:
Background
Studies have suggested that age increases susceptibility to ozone-associated mortality, but the underlying mechanisms are unclear. In a previous study, personal exposure to ozone was significantly associated with a platelet activation biomarker, plasma soluble P-selectin (sCD62P), and blood pressure in 89 healthy adults, aged 22-52 years. The present study examines whether age modifies these associations in the same adults and in additional adults.Methods
Interaction terms of age and exposure were analyzed using hierarchical Bayesian mixed effects ridge regressions. Data from a similar additional study involving 71 healthy participants, aged 19-26 years, were pooled with the data from the first study to evaluate age effect modification when more young adults were added to the analysis.Results
In the 89 adults, significant age interactions were observed for past 24-hour and 2-week ozone exposures and sCD62P. Based on the pooled data (89 plus 71 adults), a 10 ppb increase in 24-hour ozone exposure was associated with increases in sCD62P and systolic blood pressure (SBP) by 22.3% (95% CI: 14.3%, 31.2%) and 1.35 (-0.18, 2.84) mmHg, respectively, at age 25; these values increased to 48.6% (32.7%, 65.1%) and 4.98 (2.56, 7.35) mmHg, respectively, at age 40.Conclusions
These results mechanistically suggest that increasing age enhances cardiovascular effects of ozone.