Publications [#89924] of Thomas B Kepler
Papers Published
- M Zavolan, TB Kepler. "Statistical inference of sequence-dependent mutation rates.." Current opinion in genetics & development, England 11.6 (December, 2001): 612-5.
(last updated on 2006/02/08)Abstract:
Several lines of research are now converging towards an integrated understanding of mutational mechanisms and their evolutionary implications. Experimentally, crystal structures reveal the effect of sequence context on polymerase fidelity; large-scale sequencing projects generate vast amounts of sequence polymorphism data; and locus-specific databases are being constructed. Computationally, software and analytical tools have been developed to analyze mutational data, to identify mutational hot spots, and to compare the signatures of mutagenic agents.