Publications [#338992] of Lawrence Carin
Papers Published
- Dasgupta, N; Lin, S; Carin, L. "Sequential modeling for identifying CpG island locations in human genome." IEEE Signal Processing Letters 9.12 (December, 2002): 407-409. [LSP.2002.806062], [doi]
(last updated on 2024/03/27)Abstract:
We consider several sequential processing algorithms for identifying genes in human DNA, based on detecting CpG ("C proceeds G") islands. The algorithms are designed to capture the underlying statistical structure in a DNA sequence. Sequential processing using a Markov model and a hidden Markov model are shown to identify most CpG islands in annotated (marked) DNA subsequences available from publicly available DNA datasets. We also consider a wavelet-based hidden Markov tree (HMT). In the context of the HMT, we address design of adaptive wavelets matched to CpG islands, this accomplished via lifting and genetic-algorithm optimization.