Jen, J., Johnson, C., Levin, B., Molecular approaches for colorectal cancer screening.,
European journal of gastroenterology & hepatology, vol. 10 no. 3
(March, 1998),
pp. 213-7, ISSN 0954-691X
(last updated on 2011/02/11)
Abstract:
Molecular genetic approaches for colorectal cancer screening using stool samples have the potential to be very specific, sensitive and cost effective. K-ras oncogene mutation, observed in about 50% of the colorectal tumours, serves as an ideal target for such an approach. Several studies have shown that K-ras gene mutations present in the tumours can be detected from the stool of patients with colorectal cancer. The challenge for clinical application, however, is to develop a simple method for robust PCR amplification and a reliable assay for K-ras gene mutation detection in the stool samples.
Keywords:
Colorectal Neoplasms • Feces • Genes, ras • Humans • Mass Screening • Molecular Biology • Polymerase Chain Reaction • cytology • genetics* • methods • methods* • prevention & control*
