Faculty Directory Listing

Jane E. Blood-Siegfried
Tel: (919) 668-3837
Office: 3063 Pearson Building
Send Email

Jane E. Blood-Siegfried, PhD, RN, CPNP


  • Brief Bio

    I am a certified pediatric nurse practitioner and a fellow of the National Association of Pediatric Nurse Practitioners/Associates. I have a doctorate in nursing from UCLA with my focus of study in immunology and neurobiology of the young infant. My areas of interest and research include immune response, vaccines, SIDS (sudden infant death syndrome), and health maintenance. I have over 40 years of experience in pediatric primary care and have been involved in the education of nurse practitioners for the past 30 years. I have worked at several universities including UCLA, and am currently a professor at Duke University School of Nursing, an affiliate of the Duke Global Health Institute, and a lecturer at University for Developmental Studies in Tamale, Ghana. As the Director of Global Educational Partnerships and Innovation I arrange global clinical experiences for graduate students. In addition to my faculty appointment, I am working on a project to start a Family Nurse Practitioner Program at Kilimanjaro Christian Medical Center in Moshi, Tanzania and am involved in a distance educational project at University for Developmental Studies in Tamale, Ghana.

    Academic Program Affiliations

    Master of Science in Nursing Program
    Doctor of Nursing Practice Program


    PhDUniversity of California at Los Angeles School of Nursing
    MSNCalifornia State University at Fresno
    BSNCalifornia State University at Fresno

    Professional Certifications

    CPNPCertified Pediatric Nurse Practitioner

    Research Interests

    Approximately 70% of infants dying of SIDS have a current upper respiratory tract infection (URI) or have seen their health care provider for symptoms of cough and cold in the weeks before death. Causative mechanisms of SIDS are still unclear. Risk factors for SIDS include exposure to tobacco smoke and prone sleeping, with the most susceptible infants being between 2 and 6 months of age. I am most interested in the role of these risk factors as triggers of SIDS and have been examination their role during the development of autonomic “fight and flight” response in the infant. (If an infant is required to respond to a cardiovascular insult at the wrong time of development then it could be lethal.) My research reflects the hypothesis that upper respiratory infections alter events in the developing immune system, increasing susceptibility to the effects of later infections. A dual infection model of URI and bacterial sepsis is used to elucidate specific immunological events, pathogenesis of the critical infection period, and evaluate cytokines or other immune measures as biomarkers for SIDS risk. Recently, prenatal nicotine exposure has been added to the model, and findings indicate that this exposure increases mortality following normal infectious challenges. Research goals include establishing a mechanism for this synergistic effect, determining the relationship between SIDS death and the timing of infectious stimuli or other immune events, and elucidating the roles of various components of the developing immune system in SIDS.

    Clinical Interests

    I have worked in some form of clinical practice since I became a registered nurse in 1973. At present, in addition to my research and teaching activities, I am in clinical practice as a pediatric nurse practitioner at Oak Island Pediatrics in Southport, North Carolina. This rural practice specializes in the treatment of ADHD and behavioral problems as well as pediatric primary care. I provide primary care to 30 to 40 patients a day. This includes well-child care, the management of acute and chronic illnesses, and the furnishing of medications. As one of only a handful of pediatric care providers in the area, we see a large and diverse population of patients with a wide array of special needs.