Brief Bio

Margaret “Peggy” Bush joined the DUSON faculty in December, 2012. She will assume co-teaching responsibilities for the Pharmacology courses in both the MSN and ABSN programs. Dr. Bush has more than ten years' experience teaching pharmacology. Her research experience has focused on clinical drug development in the areas of oncology and hematopoietic growth factors. She has practiced as a pharmacist in both hospital and retail settings.

Dr. Bush earned a BS in Pharmacy from The Ohio State University, an MBA in Health Administration at Cleveland State University, and a PhD in Pharmacology from the University of California, Los Angeles. Dr. Bush recently completed a graduate certificate in E-Learning from North Carolina State University. Her professional interests include identifying instructional strategies for teaching pharmacology that engage learners and promote critical thinking through the use of problem-solving approaches.

Academic Program Affiliations

Master of Science in Nursing Program

Education

PhD	University of California, Los Angeles
MBA	Cleveland State University
BS Pharm	The Ohio State University

Professional Certifications

RPh	Licensed Pharmacist

Research Interests

Dr. Bush’s clinical research experience includes study design and protocol development, operations, management and reporting for Phase 1 through Phase 3 investigational drug studies. Her experience has focused in the areas of oncology and hematopoietic growth factors. Her basic research while at UCLA, identified nitric oxide as the mediator of nonadrenergic, noncholinergic neurotransmission that leads to vascular smooth muscle relaxation in erectile tissue, providing the pharmacological rationale for subsequent clinical development of phosphodiesterase-5 inhibitor drugs for the treatment of erectile dysfunction.

Awards and Honors

• 2005 Excellence in Teaching Award, Durham Technical Community College

• 1984 Inducted, Beta Gamma Sigma (Business Scholastic Honorary)

• 1979 Inducted, Rho Chi Society (Pharmacy Scholastic Honorary)

Areas of Expertise

• Clinical Research Management
• Oncology
• Pharmacology

Areas of Interest

• E-learning

Representative Publications

• 2015 -- Pubmed # 25719569 Bush, P. A., Hueckel, R. M., Robinson, D., Seelinger, T. A., Molloy, M. A. Cultivating a Culture of Medication Safety in Prelicensure Nursing Students. Nurse Educ. Jul-Aug, 2015; 40(4); 169-73

• 1998 -- Bush, P. Overview of biotechnology. Journal of Pharmacy Practice. 1998; 11 6-12

• 1998 -- Bush, P. Pharmacotherapeutics of biotechnology-derived products. Journal of Pharmacy Practice. 1998; 11 54-71

• 1993 -- Bush, P.A., Aronson, W.J., Rajfer, J., Ignarro, L.J. The L-arginine-nitric oxide-cyclic GMP pathway mediates inhibitory nonadrenergic-noncholinergic neurotransmission in the corpus cavernosum of human and rabbit. Circulation. 1993; 87(5); V30-V32

• 1992 -- Pubmed # 1378725 Bush, P. A., Gonzalez, N. E., Ignarro, L. J. Biosynthesis of nitric oxide and citrulline from L-arginine by constitutive nitric oxide synthase present in rabbit corpus cavernosum. Biochem Biophys Res Commun. July, 1992; 186(1); 308-14

• 1992 -- Pubmed # 1378272 Bush, P. A., Gonzalez, N. E., Griscavage, J. M., Ignarro, L. J. Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. Biochem Biophys Res Commun. June, 1992; 185(3); 960-6

• 1992 -- Pubmed # 1317469 Bush, P. A., Aronson, W. J., Buga, G. M., Rajfer, J., Ignarro, L. J. Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urol. June, 1992; 147(6); 1650-5

• 1992 -- Pubmed # 1309211 Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., Ignarro, L. J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med. January, 1992; 326(2); 90-4

• 1992 -- Bush, P.A., Aronson, W. J., Rajfer, J., Buga, G..M., Ignarro, L. J. Comparison of nonadrenergic, noncholinergic, and nitric oxide-mediated relaxation of corpus cavernosum. International journal of impotence research. 1992; 4 85-93

• 1990 -- Pubmed # 1975643 Ignarro, L. J., Bush, P. A., Buga, G. M., Rajfer, J. Neurotransmitter identity doubt. Nature. September, 1990; 347(6289); 131-2

• 1990 -- Pubmed # 2166511 Ignarro, L. J., Bush, P. A., Buga, G. M., Wood, K. S., Fukuto, J. M., Rajfer, J. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun. July, 1990; 170(2); 843-50

• 1989 -- Pubmed # 2510722 Gold, M. E., Bush, P. A., Ignarro, L. J. Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochem Biophys Res Commun. October, 1989; 164(2); 714-21

Grant Funding (selected)