Brief Bio

Dr. Silva is Research Associate Professor and Statistician in the Office of Research Affairs at the Duke University School of Nursing. She also has appointments in the Department of Psychiatry and Behavioral Sciences of the Duke University School of Medicine and in the Department of Clinical Trials Statistics of the Duke Clinical Research Institute.

Dr. Silva has extensive formal training in both biostatistics and behavioral statistics, and has taught statistics courses designed for psychology students and neuropsychiatry research fellows. She is a senior statistician on the NIMH Data Safety and Monitoring Board (DSMB) as well as a statistical reviewer for several industry-sponsored DSMBs.

Dr. Silva earned her PhD from the Experimental Psychology-Cognitive Neuroscience Program at North Carolina State University, and completed a NIH-funded post-doctoral fellowship in Neuropsychology and Cognitive Neuroscience at the Brain and Development Research Center at the University of North Carolina at Chapel Hill (UNC-CH). Before coming to Duke in 1999, Dr. Silva was a member of the faculty in the Department of Psychiatry at the UNC-CH School of Medicine, where she served as the Director of the Neurobehavioral Assessment Core and the Associate Director of the Data Management and Biostatistics Core for their NIMH-sponsored Mental Health and Neurosciences Clinical Research Center.

Academic Program Affiliations

Education

Research Interests

Dr. Silva currently serves as the Statistical PI for the Substance Use Outcomes Following Treatment for Adolescent Depression (SOFTAD) study. She is also a member of the NIMH Interventions Committee for Disorders Involving Children and their Families (ITVC).

Her statistical expertise includes the: (1) design of longitudinal studies; (2) application of hierarchical or mixed models; (3) analysis of moderator and mediator variables; (4) use of Generalized Estimating Equations; (5) assessment of reliability and validity; and (5) development and implementation of randomization schemes.

Awards and Honors

• 2007 AACAP Klingenstein Award for Research (Presented to the Treatment for Adolescents with Depression Study Team), American Academy of Child and Adolescent Psychiatry

• 2005 AACAP Klingenstein Award for Research (Presented to the Treatment for Adolescents with Depression Study Team), American Academy of Child and Adolescent Psychiatry

• 1994 NARSAD Young Investigator Award, National Alliance for Research on Schizophrenia and Depression

• 1984 Graduate Student Association Teaching Award, North Carolina State University

• 1978 Distinguished Student Award, East Carolina University

• 1978 North Carolina Academy of Science Research Award, East Carolina University

• 1977 National Science Foundation Research Award, East Carolina University

• 1976 Academic Achievement Award, East Carolina University

Areas of Expertise

• Psychiatric / Behavioral Health
• Research Methods

Representative Publications

• 2015 -- Pubmed # 26448157 Molloy, M. A., Sabol, V. K., Silva, S. G., Guimond, M. E. Using Trigger Films as a Bariatric Sensitivity Intervention: Improving Nursing Students' Attitudes and Beliefs About Caring for Obese Patients. Nurse Educ. October, 2015 Epub ahead of print;

• 2015 -- Pubmed # 26035553 Hummer, D. B., Silva, S. G., Yap, T. L., Toles, M., Anderson, R. A. Implementation of an Exercise Program in an Assisted Living Facility. J Nurs Care Qual. Oct-Dec, 2015; 30(4); 373-9

• 2015 -- Pubmed # 26148325 Winkler, M. R., Hockenberry, M. J., McCarthy, K. S., Silva, S. G. Trajectories of Obesity and Overweight Rates Among Survivors of Childhood Acute Lymphoblastic Leukemia. Oncol Nurs Forum. July 1, 2015; 42(4); E287-93

• 2015 -- Pubmed # 25761644 Relf, M. V., Silva, S. G., Williams, M. S., Moore, E., Arscott, J., Caiola, C., Barroso, J. Feasibility of Using an iPod Touch Device and Acceptability of a Stigma Reduction Intervention with HIV-Infected Women in the Deep South. AIDS Behav. March 12, 2015; 42(4); E287-93

• 2015 -- Pubmed # 25554554 Andrews, L., Silva, S. G., Kaplan, S., Zimbro, K. Delirium monitoring and patient outcomes in a general intensive care unit. Am J Crit Care. January 1, 2015; 24(1); 48-56

• 2015 -- Pubmed # 24661263 Brenner, S. L., Burns, B. J., Curry, J. F., Silva, S. G., Kratochvil, C. J., Domino, M. E. Mental health service use among adolescents following participation in a randomized clinical trial for depression. J Clin Child Adolesc Psychol. 2015; 44(4); 551-8 PMCID: PMC4175368

• 2014 -- Pubmed # 25356894 Freiermuth, C. E., Haywood Jr, C., Silva, S., Cline, D. M., Kayle, M., Sullivan, D., Thornton, V., Tanabe, P. Attitudes toward patients with sickle cell disease in a multicenter sample of emergency department providers. Adv Emerg Nurs J. Oct-Dec, 2014; 36(4); 335-47 PMCID: PMC4405136

• 2014 -- Pubmed # 25084499 Barroso, J., Relf, M. V., Williams, M. S., Arscott, J., Moore, E. D., Caiola, C., Silva, S. G. A Randomized Controlled Trial of the Efficacy of a Stigma Reduction Intervention for HIV-Infected Women in the Deep South. AIDS Patient Care STDS. September, 2014; 28(9); 489-98 PMCID: PMC4135326

• 2014 -- Pubmed # 25167608 Wofford, K., Hertzberg, M., Silva, S., Vacchiano, C. Effect of elective surgery on subjective health in veterans with chronic posttraumatic stress disorder. AANA J. August, 2014; 82(4); 285-92

• 2014 -- Pubmed # 24633638 Ouden, D. D., Derouin, A., Silva, S., Khan, A. Screening for chlamydia: Are you doing it? Nurse Pract. April, 2014; 39(4); 41-7

• 2014 -- Pubmed # 24675632 Ryan, D. J., Mikula, E. B., Germana, S., Silva, S. G., Derouin, A. Screening for critical congenital heart disease in newborns using pulse oximetry: evaluation of nurses' knowledge and adherence. Adv Neonatal Care. April, 2014; 14(2); 119-28

• 2014 -- Pubmed # 24121861 Harris, T., Silva, S., Intini, R., Smith, T., Vorderstrasse, A. Group diabetes self-management education in a primary care setting: a quality improvement project. J Nurs Care Qual. April-June, 2014; 29(2); 188-93

• 2014 -- Pubmed # 24944436 Jacobs, R. H., Becker, S. J., Curry, J. F., Silva, S. G., Ginsburg, G. S., Henry, D. B., Reinecke, M. A. Increasing Positive Outlook Partially Mediates the Effect of Empirically Supported Treatments on Depression Symptoms Among Adolescents. J Cogn Psychother. December 1, 2014; 28(1); 3-19

• 2013 -- Pubmed # 24050486 Shaw, R. J., Bosworth, H. B., Silva, S. S., Lipkus, I. M., Davis, L. L., Sha, R. S., Johnson, C. M. Mobile Health Messages Help Sustain Recent Weight Loss. Am J Med. September, 2013;

• 2013 -- Pubmed # 23561066 Carlson, K. J., Silva, S. G., Langley, J., Johnson, C. Mindful-Veteran: the implementation of a brief stress reduction course. Complement Ther Clin Pract. May, 2013; 19(2); 89-96

• 2013 -- Pubmed # 25100678 Shaw, R. J., Bosworth, H. B., Hess, J. C., Silva, S. G., Lipkus, I. M., Davis, L. L., Johnson, C. M. Development of a Theoretically Driven mHealth Text Messaging Application for Sustaining Recent Weight Loss. JMIR Mhealth Uhealth. 2013; 1(1); e5

• 2012 -- Pubmed # 22250853 Curry, J., Silva, S., Rohde, P., Ginsburg, G., Kennard, B., Kratochvil, C., Simons, A., Kirchner, J., May, D., Mayes, T., Feeny, N., Albano, A. M., Lavanier, S., Reinecke, M., Jacobs, R., Becker-Weidman, E., Weller, E., Emslie, G., Walkup, J., Kastelic, E., Burns, B., Wells, K., March, J. Onset of alcohol or substance use disorders following treatment for adolescent depression. J Consult Clin Psychol. April, 2012; 80(2); 299-312 PMCID: PMC3314095

• 2012 -- Pubmed # 22215622 Leach, R. E., Jessmon, P., Coutifaris, C., Kruger, M., Myers, E. R., Ali-Fehmi, R., Carson, S. A., Legro, R. S., Schlaff, W. D., Carr, B. R., Steinkampf, M. P., Silva, S., Leppert, P. C., Giudice, L., Diamond, M. P., Armant, D. R., Reproductive Medicine Network, High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples. Hum Reprod. March 1, 2012; 27(3); 814-28 PMCID: PMC3279126

• 2012 -- Pubmed # 21918212 Kerr, J., Price, M., Kotch, J., Willis, S., Fisher, M., Silva, S. Does contact by a family nurse practitioner decrease early school absence? J Sch Nurs. February, 2012; 28(1); 38-46

• 2011 -- Pubmed # 22085611 Emory, S. L., Silva, S. G., Christopher, E. J., Edwards, P. B., Wahl, L. E. Stepping to stability and fall prevention in adult psychiatric patients. J Psychosoc Nurs Ment Health Serv. December, 2011; 49(12); 30-6

• 2011 -- Pubmed # 22092914 Brandon, D. H., Tully, K. P., Silva, S. G., Malcolm, W. F., Murtha, A. P., Turner, B. S., Holditch-Davis, D. Emotional responses of mothers of late-preterm and term infants. J Obstet Gynecol Neonatal Nurs. November, 2011; 40(6); 719-31

• 2011 -- Pubmed # 21960127 Tillman, S., Brandon, D. H., Silva, S. G. Evaluation of human milk fortification from the time of the first feeding: effects on infants of less than 31 weeks gestational age. J Perinatol. September, 2011;

• 2011 -- Pubmed # 20957515 Amaya, M. M., Reinecke, M. A., Silva, S. G., March, J. S. Parental marital discord and treatment response in depressed adolescents. J Abnorm Child Psychol. April, 2011; 39(3); 401-11

• 2011 -- Pubmed # 21324590 Keefe, F. J., Shelby, R. A., Somers, T. J., Varia, I., Blazing, M., Waters, S. J., McKee, D., Silva, S., She, L., Blumenthal, J. A., O'Connor, J., Knowles, V., Johnson, P., Bradley, L. Effects of coping skills training and sertraline in patients with non-cardiac chest pain: A randomized controlled study. Pain. April, 2011; 152(4); 730-41

• 2011 -- Pubmed # 21041606 Curry, J., Silva, S., Rohde, P., Ginsburg, G., Kratochvil, C., Simons, A., Kirchner, J., May, D., Kennard, B., Mayes, T., Feeny, N., Albano, A. M., Lavanier, S., Reinecke, M., Jacobs, R., Becker-Weidman, E., Weller, E., Emslie, G., Walkup, J., Kastelic, E., Burns, B., Wells, K., March, J. Recovery and recurrence following treatment for adolescent major depression. Arch Gen Psychiatry. 2011; 68(3); 263-9 PMCID: PMC3074362

• 2010 -- Pubmed # 20723799 O'Connor, C. M., Jiang, W., Kuchibhatla, M., Silva, S. G., Cuffe, M. S., Callwood, D. D., Zakhary, B., Stough, W. G., Arias, R. M., Rivelli, S. K., Krishnan, R., SADHART-CHF Investigators Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol. August, 2010; 56(9); 692-9

• 2010 -- Pubmed # 20843506 Jacobs, R. H., Reinecke, M. A., Gollan, J. K., Jordan, N., Silva, S. G., March, J. S. Extreme thinking in clinically depressed adolescents: Results from the Treatment for Adolescents with Depression Study (TADS). Behav Res Ther. August, 2010; 48(11); 1155-9 PMCID: PMC2964160

• 2010 -- Pubmed # 20589566 Jacobs, R. H., Becker-Weidman, E. G., Reinecke, M. A., Jordan, N., Silva, S. G., Rohde, P., March, J. S. Treating depression and oppositional behavior in adolescents. J Clin Child Adolesc Psychol. July, 2010; 39(4); 559-67 PMCID: PMC2964140

• 2010 -- Pubmed # 20438153 Stein, G. L., Curry, J. F., Hersh, J., Breland-Noble, A., March, J., Silva, S. G., Reinecke, M. A., Jacobs, R. Ethnic differences among adolescents beginning treatment for depression. Cultur Divers Ethnic Minor Psychol. April, 2010; 16(2); 152-8

• 2010 -- Pubmed # 20215935 Lewis, C. C., Simons, A. D., Nguyen, L. J., Murakami, J. L., Reid, M. W., Silva, S. G., March, J. S. Impact of childhood trauma on treatment outcome in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. February, 2010; 49(2); 132-40

• 2010 -- Pubmed # 19775677 Becker-Weidman, E. G., Jacobs, R. H., Reinecke, M. A., Silva, S. G., March, J. S. Social problem-solving among adolescents treated for depression. Behav Res Ther. January, 2010; 48(1); 11-8 PMCID: PMC2812620

• 2009 -- Pubmed # 20183665 Feeny, N. C., Silva, S. G., Reinecke, M. A., McNulty, S., Findling, R. L., Rohde, P., Curry, J. F., Ginsburg, G. S., Kratochvil, C. J., Pathak, S. M., May, D. E., Kennard, B. D., Simons, A. D., Wells, K. C., Robins, M., Rosenberg, D., March, J. S. An exploratory analysis of the impact of family functioning on treatment for depression in adolescents. J Clin Child Adolesc Psychol. November, 2009; 38(6); 814-25

• 2009 -- Pubmed # 20183663 Ginsburg, G. S., Silva, S. G., Jacobs, R. H., Tonev, S., Hoyle, R. H., Kingery, J. N., Reinecke, M. A., Curry, J. F., March, J. S. Cognitive measures of adolescent depression: unique or unitary constructs? J Clin Child Adolesc Psychol. November, 2009; 38(6); 790-802 PMCID: PMC2829715

• 2009 -- Pubmed # 20183664 Jacobs, R. H., Silva, S. G., Reinecke, M. A., Curry, J. F., Ginsburg, G. S., Kratochvil, C. J., March, J. S. Dysfunctional attitudes scale perfectionism: a predictor and partial mediator of acute treatment outcome among clinically depressed adolescents. J Clin Child Adolesc Psychol. November, 2009; 38(6); 803-13 PMCID: PMC2829732

• 2009 -- Pubmed # 20183661 Kingery, J. N., Kepley, H. O., Ginsburg, G. S., Walkup, J. T., Silva, S. G., Hoyle, R. H., Reinecke, M. A., March, J. S. Factor structure and psychometric properties of the Children's Negative Cognitive Error Questionnaire with a clinically depressed adolescent sample. J Clin Child Adolesc Psychol. November, 2009; 38(6); 768-80

• 2009 -- Pubmed # 20183666 Domino, M. E., Burns, B. J., Mario, J., Reinecke, M. A., Vitiello, B., Weller, E. B., Kratochvil, C. J., May, D. E., Feeny, N. C., Robins, M., Hallin, M. J., Silva, S. G., March, J. S. Service use and costs of care for depressed adolescents: who uses and who pays? J Clin Child Adolesc Psychol. November, 2009; 38(6); 826-36

• 2009 -- Pubmed # 20183662 Rogers, G. M., Park, J., Essex, M. J., Klein, M. H., Silva, S. G., Hoyle, R. H., Curry, J. F., Feeny, N. C., Kennard, B., Kratochvil, C. J., Pathak, S., Reinecke, M. A., Rosenberg, D. R., Weller, E. B., March, J. S. The dysfunctional attitudes scale: psychometric properties in depressed adolescents. J Clin Child Adolesc Psychol. November, 2009; 38(6); 781-9

• 2009 -- Pubmed # 19737857 Shelby, R. A., Somers, T. J., Keefe, F. J., Silva, S. G., McKee, D. C., She, L., Waters, S. J., Varia, I., Riordan, Y. B., Knowles, V. M., Blazing, M., Blumenthal, J. A., Johnson, P. Pain catastrophizing in patients with noncardiac chest pain: relationships with pain, anxiety, and disability. Psychosom Med. October, 2009; 71(8); 861-8 PMCID: PMC2762482

• 2009 -- Pubmed # 19723787 Treatment for Adolescents With Depression Study (TADS) Team, March, J., Silva, S., Curry, J., Wells, K., Fairbank, J., Burns, B., Domino, M., et al. The Treatment for Adolescents With Depression Study (TADS): outcomes over 1 year of naturalistic follow-up. Am J Psychiatry. October, 2009; 166(10); 1141-1149

• 2009 -- Pubmed # 19877976 Kratochvil, C. J., May, D. E., Silva, S. G., Madaan, V., Puumala, S. E., Curry, J. F., Walkup, J., Kepley, H., Vitiello, B., March, J. S. Treatment response in depressed adolescents with and without co-morbid attention-deficit/hyperactivity disorder in the Treatment for Adolescents with Depression Study. J Child Adolesc Psychopharmacol. October, 2009; 19(5); 519-27 PMCID: PMC2830214

• 2009 -- Pubmed # 19465880 Domino, M. E., Foster, E. M., Vitiello, B., Kratochvil, C. J., Burns, B. J., Silva, S. G., Reinecke, M. A., March, J. S. Relative cost-effectiveness of treatments for adolescent depression: 36-week results from the TADS randomized trial. J Am Acad Child Adolesc Psychiatry. July, 2009; 48(7); 711-20

• 2009 -- Pubmed # 19485584 Lewis, C. C., Simons, A. D., Silva, S. G., Rohde, P., Small, D. M., Murakami, J. L., High, R. R., March, J. S. The role of readiness to change in response to treatment of adolescent depression. J Consult Clin Psychol. June, 2009; 77(3); 422-8 PMCID: PMC2822468

• 2009 -- Pubmed # 19368751 Becker-Weidman, E. G., Reinecke, M. A., Jacobs, R. H., Martinovich, Z., Silva, S. G., March, J. S. Predictors of hopelessness among clinically depressed youth. Behav Cogn Psychother. May, 2009; 37(3); 267-91

• 2009 -- Pubmed # 19552869 Vitiello, B., Silva, S. G., Rohde, P., Kratochvil, C. J., Kennard, B. D., Reinecke, M. A., Mayes, T. L., Posner, K., May, D. E., March, J. S. Suicidal events in the Treatment for Adolescents With Depression Study (TADS). J Clin Psychiatry. May, 2009; 70(5); 741-7 PMCID: PMC2702701

• 2009 -- Pubmed # 19147693 Kennard, B. D., Silva, S. G., Mayes, T. L., Rohde, P., Hughes, J. L., Vitiello, B., Kratochvil, C. J., Curry, J. F., Emslie, G. J., Reinecke, M. A., March, J. S., TADS, Assessment of safety and long-term outcomes of initial treatment with placebo in TADS. Am J Psychiatry. March, 2009; 166(3); 337-44 PMCID: PMC2823118

• 2009 -- Pubmed # 19320979 Shapiro, M., Silva, S. G., Compton, S., Chrisman, A., Deveaugh-Geiss, J., Breland-Noble, A., Kondo, D., Kirchner, J., March, J. S. The child and adolescent psychiatry trials network (CAPTN): infrastructure development and lessons learned. Child Adolesc Psychiatry Ment Health. March, 2009; 3(1); 12 PMCID: PMC2673205

• 2009 -- Pubmed # 19127172 Kennard, B. D., Silva, S. G., Tonev, S., Rohde, P., Hughes, J. L., Vitiello, B., Kratochvil, C. J., Curry, J. F., Emslie, G. J., Reinecke, M., March, J. Remission and recovery in the Treatment for Adolescents with Depression Study (TADS): acute and long-term outcomes. J Am Acad Child Adolesc Psychiatry. February, 2009; 48(2); 186-95 PMCID: PMC2843506

• 2008 -- Pubmed # 18509755 Small, D. M., Simons, A. D., Yovanoff, P., Silva, S. G., Lewis, C. C., Murakami, J. L., March, J. Depressed adolescents and comorbid psychiatric disorders: are there differences in the presentation of depression? J Abnorm Child Psychol. October, 2008; 36(7); 1015-28

• 2008 -- Pubmed # 18760123 Jiang, W., O'Connor, C., Silva, S. G., Kuchibhatla, M., Cuffe, M. S., Callwood, D. D., Zakhary, B., Henke, E., Arias, R. M., Krishnan, R., SADHART-CHF Investigators, Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure. Am Heart J. September, 2008; 156(3); 437-44 PMCID: PMC2659472

• 2008 -- Pubmed # 18340457 Guidetti, L., Emerenziani, G. P., Gallotta, M. C., Da Silva, S. G., Baldari, C. Energy cost and energy sources of a ballet dance exercise in female adolescents with different technical ability. Eur J Appl Physiol. June, 2008; 103(3); 315-21

• 2008 -- Pubmed # 19169367 Jacobs, R. H., Klein, J. B., Reinecke, M. A., Silva, S. G., Tonev, S., Breland-Noble, A., Martinovich, Z., Kratochvil, C. J., Rezac, A. J., Jones, J., March, J. S. Ethnic Differences in Attributions and Treatment Expectancies for Adolescent Depression. Int J Cogn Ther. June 1, 2008; 1(2); 163-178 PMCID: PMC2629601

• 2008 -- Pubmed # 18413703 Domino, M. E., Burns, B. J., Silva, S. G., Kratochvil, C. J., Vitiello, B., Reinecke, M. A., Mario, J., March, J. S. Cost-effectiveness of treatments for adolescent depression: results from TADS. Am J Psychiatry. May, 2008; 165(5); 588-96

• 2008 -- Pubmed # 18507848 Wehmeier, P. M., Schacht, A., Lehmann, M., Dittmann, R. W., Silva, S. G., March, J. S. Emotional well-being in children and adolescents treated with atomoxetine for attention-deficit/hyperactivity disorder: Findings from a patient, parent and physician perspective using items from the pediatric adverse event rating scale (PAERS). Child Adolesc Psychiatry Ment Health. May, 2008; 2(1); 11 PMCID: PMC2430545

• 2008 -- Pubmed # 18391133 Rohde, P., Silva, S. G., Tonev, S. T., Kennard, B. D., Vitiello, B., Kratochvil, C. J., Reinecke, M. A., Curry, J. F., Simons, A. D., March, J. S. Achievement and maintenance of sustained response during the Treatment for Adolescents With Depression Study continuation and maintenance therapy. Arch Gen Psychiatry. April, 2008; 65(4); 447-55 PMCID: PMC2587406

• 2008 -- Becker, S. J., Sanchez, C. C., Curry, J. F., Silva, S. G., Tonev, S. T. Cognitive-behavioral therapy for adolescent depression: Processes of cognitive change. Psychiatric Times. 2008; 12 1-2

• 2007 -- Pubmed # 18030086 Vitiello, B., Kratochvil, C. J., Silva, S., Curry, J., Reinecke, M., Pathak, S., Waslick, B., Hughes, C. W., Prentice, E. D., May, D. E., March, J. S. Research knowledge among the participants in the Treatment for Adolescents With Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. December, 2007; 46(12); 1642-50

• 2007 -- Pubmed # 17907854 Herman, K. C., Ostrander, R., Walkup, J. T., Silva, S. G., March, J. S. Empirically derived subtypes of adolescent depression: latent profile analysis of co-occurring symptoms in the Treatment for Adolescents with Depression Study (TADS). J Consult Clin Psychol. October, 2007; 75(5); 716-28

• 2007 -- Pubmed # 17909125 March, J. S., Silva, S., Petrycki, S., Curry, J., Wells, K., Fairbank, J., Burns, B., Domino, M., McNulty, S., Vitiello, B., Severe, J. The Treatment for Adolescents With Depression Study (TADS): long-term effectiveness and safety outcomes. Arch Gen Psychiatry. October, 2007; 64(10); 1132-43

• 2007 -- Pubmed # 17581444 May, D. E., Hallin, M. J., Kratochvil, C. J., Puumala, S. E., Smith, L. S., Reinecke, M. A., Silva, S. G., Weller, E. B., Vitiello, B., Breland-Noble, A., March, J. S. Factors associated with recruitment and screening in the Treatment for Adolescents With Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. July, 2007; 46(7); 801-10

• 2007 -- Pubmed # 17450048 May, D. E., Kratochvil, C. J., Puumala, S. E., Silva, S. G., Rezac, A. J., Hallin, M. J., Reinecke, M. A., Vitiello, B., Weller, E. B., Pathak, S., Simons, A. D., March, J. S. A manual-based intervention to address clinical crises and retain patients in the Treatment of Adolescents With Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. May, 2007; 46(5); 573-81

• 2006 -- Pubmed # 17135986 Kratochvil, C., Emslie, G., Silva, S., McNulty, S., Walkup, J., Curry, J., Reinecke, M., Vitiello, B., Rohde, P., Feeny, N., Casat, C., Pathak, S., Weller, E., May, D., Mayes, T., Robins, M., March, J., TADS Team, Acute time to response in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. December, 2006; 45(12); 1412-8

• 2006 -- Pubmed # 17135987 Vitiello, B., Rohde, P., Silva, S., Wells, K., Casat, C., Waslick, B., Simons, A., Reinecke, M., Weller, E., Kratochvil, C., Walkup, J., Pathak, S., Robins, M., March, J., TADS Team, Functioning and quality of life in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. December, 2006; 45(12); 1419-26

• 2006 -- Pubmed # 17135988 Curry, J., Rohde, P., Simons, A., Silva, S., Vitiello, B., Kratochvil, C., Reinecke, M., Feeny, N., Wells, K., Pathak, S., Weller, E., Rosenberg, D., Kennard, B., Robins, M., Ginsburg, G., March, J., TADS Team, Predictors and moderators of acute outcome in the Treatment for Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. December, 2006; 45(12); 1427-39

• 2006 -- Pubmed # 17135985 Kennard, B., Silva, S., Vitiello, B., Curry, J., Kratochvil, C., Simons, A., Hughes, J., Feeny, N., Weller, E., Sweeney, M., Reinecke, M., Pathak, S., Ginsburg, G., Emslie, G., March, J., TADS Team, Remission and residual symptoms after short-term treatment in the Treatment of Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. December, 2006; 45(12); 1404-11

• 2006 -- Pubmed # 17135984 March, J., Silva, S., Vitiello, B., TADS Team, The Treatment for Adolescents with Depression Study (TADS): methods and message at 12 weeks. J Am Acad Child Adolesc Psychiatry. December, 2006; 45(12); 1393-403

• 2006 -- Pubmed # 17135989 Emslie, G., Kratochvil, C., Vitiello, B., Silva, S., Mayes, T., McNulty, S., Weller, E., Waslick, B., Casat, C., Walkup, J., Pathak, S., Rohde, P., Posner, K., March, J., Columbia Suicidality Classification Group,, TADS Team, Treatment for Adolescents with Depression Study (TADS): safety results. J Am Acad Child Adolesc Psychiatry. December, 2006; 45(12); 1440-55

• 2006 -- Pubmed # 16540810 DeVeaugh-Geiss, J., March, J., Shapiro, M., Andreason, P. J., Emslie, G., Ford, L. M., Greenhill, L., Murphy, D., Prentice, E., Roberts, R., Silva, S., Swanson, J. M., van Zwieten-Boot, B., Vitiello, B., Wagner, K. D., Mangum, B. Child and adolescent psychopharmacology in the new millennium: a workshop for academia, industry, and government. J Am Acad Child Adolesc Psychiatry. March, 2006; 45(3); 261-70

• 2005 -- Pubmed # 15911461 Myers, E. R., Silva, S. G., Hafley, G., Kunselman, A. R., Nestler, J. E., Legro, R. S., National Institute of Child Health, Human Development Reproductive Medicine Network, Estimating live birth rates after ovulation induction in polycystic ovary syndrome: sample size calculations for the pregnancy in polycystic ovary syndrome trial. Contemp Clin Trials. June, 2005; 26(3); 271-80

• 2005 -- Pubmed # 15863782 March, J. S., Silva, S. G., Compton, S., Shapiro, M., Califf, R., Krishnan, R. The case for practical clinical trials in psychiatry. Am J Psychiatry. May, 2005; 162(5); 836-46

• 2005 -- Pubmed # 15608541 Treatment for Adolescents with Depression Study (TADS) Team, The Treatment for Adolescents With Depression Study (TADS): demographic and clinical characteristics. J Am Acad Child Adolesc Psychiatry. January, 2005; 44(1); 28-40

• 2005 -- Pathak, S., Kratochvil, C. J., Rogers, G. M., Silva, S. G., Vitiello, B., Weller, E. B., March, J. S. Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: Initial lessons from the Treatment for Adolescents with Depression Study. Current Psychiatry Reports. 2005; 7(6); 429-434

• 2004 -- Pubmed # 15533341 McGovern, P. G., Myers, E. R., Silva, S., Coutifaris, C., Carson, S. A., Legro, R. S., Schlaff, W. D., Carr, B. R., Steinkampf, M. P., Giudice, L. C., Leppert, P. C., Diamond, M. P., NICHD National Cooperative Reproductive Medicine Network, Absence of secretory endometrium after false-positive home urine luteinizing hormone testing. Fertil Steril. November, 2004; 82(5); 1273-7

• 2004 -- Pubmed # 15533342 Myers, E. R., Silva, S., Barnhart, K., Groben, P. A., Richardson, M. S., Robboy, S. J., Leppert, P., Coutifaris, C., NICHD National Cooperative Reproductive Medicine Network, Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women. Fertil Steril. November, 2004; 82(5); 1278-82

• 2004 -- Pubmed # 15475681 Baldewicz, T. T., Leserman, J., Silva, S. G., Petitto, J. M., Golden, R. N., Perkins, D. O., Barroso, J., Evans, D. L. Changes in neuropsychological functioning with progression of HIV-1 infection: results of an 8-year longitudinal investigation. AIDS Behav. September, 2004; 8(3); 345-55

• 2004 -- Pubmed # 15315995 March, J., Silva, S., Petrycki S., Curry, J., Wells, K., Fairbank J., Burns B., Domino M., McNulty S., Vitiello B., Severe J., Treatment for Adolescents With Depression Study (TADS) Team. Fluoxetine, cognitive-behavioral therapy, and their combination for adolescents with depression. JAMA. 2004; 292(7); 807-820

• 2004 -- Pubmed # 15100557 March, J. S., Silva, S. G., Compton, S., Anthony, G., DeVeaugh-Geiss, J., Califf, R., Krishnan, R. The Child and Adolescent Psychiatry Trials Network (CAPTN). J Am Acad Child Adolesc Psychiatry. May, 2004; 43(5); 515-8

• 2003 -- Pubmed # 12957700 Hartman, M., Steketee, M. C., Silva, S., Lanning, K., Andersson, C. Wisconsin Card Sorting Test performance in schizophrenia: the role of working memory. Schizophr Res. October, 2003; 63(3); 201-17

• 2003 -- Pubmed # 12707557 Treatment for Adolescents With Depression Study Team, Treatment for Adolescents With Depression Study (TADS): rationale, design, and methods. J Am Acad Child Adolesc Psychiatry. May, 2003; 42(5); 531-42

• 2001 -- Pubmed # 11295375 Gilmore, J. H., van Tol, J. J., Lewis Streicher, H., Williamson, K., Cohen, S. B., Greenwood, R. S., Charles, H. C., Kliewer, M. A., Whitt, J. K., Silva, S. G., Hertzberg, B. S., Chescheir, N. C. Outcome in children with fetal mild ventriculomegaly: a case series. Schizophr Res. March 30, 2001; 48(2-3); 219-26

• 2000 -- Pubmed # 10789020 Petitto, J. M., Leserman, J., Perkins, D. O., Stern, R. A., Silva, S. G., Gettes, D., Zheng, B., Folds, J. D., Golden, R. N., Evans, D. L. High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status. Behav Med. Winter, 2000; 25(4); 143-51

• 2000 -- Pubmed # 10910783 Leserman, J., Petitto, J. M., Golden, R. N., Gaynes, B. N., Gu, H., Perkins, D. O., Silva, S. G., Folds, J. D., Evans, D. L. Impact of stressful life events, depression, social support, coping, and cortisol on progression to AIDS. Am J Psychiatry. August, 2000; 157(8); 1221-8

• 1999 -- Pubmed # 10367622 Leserman, J., Jackson, E. D., Petitto, J. M., Golden, R. N., Silva, S. G., Perkins, D. O., Cai, J., Folds, J. D., Evans, D. L. Progression to AIDS: the effects of stress, depressive symptoms, and social support. Psychosom Med. July 21, 1999; 61(3); 397-406

• 1999 -- Keefe, R. S. E., Bollini, A. M., Silva, S. G. Do novel antipsychotics improve cognition? Report of a meta-analysis. Psychiatric Annals. November, 1999; 29(11); 623-9

• 1999 -- Pubmed # 10416727 Keefe, R. S., Silva, S. G., Perkins, D. O., Lieberman, J. A. The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophr Bull. 1999; 25(2); 201-22

• 1998 -- Pubmed # 9789905 Gilmore, J. H., van Tol, J., Kliewer, M. A., Silva, S. G., Cohen, S. B., Hertzberg, B. S., Chescheir, N. C. Mild ventriculomegaly detected in utero with ultrasound: clinical associations and implications for schizophrenia. Schizophr Res. October 9, 1998; 33(3); 133-40

• 1998 -- Pubmed # 9531015 Robertson, K., Fiscus, S., Kapoor, C., Robertson, W., Schneider, G., Shepard, R., Howe, L., Silva, S., Hall, C. CSF, plasma viral load and HIV associated dementia. J Neurovirol. February, 1998; 4(1); 90-4

• 1998 -- Silva, S. G., Garbutt, J. C., Haggerty, J. J. Jr., Prange, A. J. Jr. Neuropsychiatric aspects of subclinical hypothyroidism. Directions in Psychiatry. 1998; 18 255-266

• 1998 -- Janowsky, D. S., Hong, L., Morter, S., Silva, S. G., Howe, L. L. Underlying personality characteristics related to affective disorders and suicidality. In In Neurobiology of Depression and Related Disorders, edited by Nomura. J. 1998; pp. 9-30. Tsu, Mie, Japan: Mie Academic Press.

• 1997 -- Pubmed # 9251156 Nicholas, L. M., Tancer, M. E., Silva, S. G., Underwood, L. E., Stabler, B. Short stature, growth hormone deficiency, and social anxiety. Psychosom Med. September, 1997; 59(4); 372-5

• 1997 -- Pubmed # 9137117 Evans, D. L., Leserman, J., Perkins, D. O., Stern, R. A., Murphy, C., Zheng, B., Gettes, D., Longmate, J. A., Silva, S. G., van der Horst, C. M., Hall, C. D., Folds, J. D., Golden, R. N., Petitto, J. M. Severe life stress as a predictor of early disease progression in HIV infection. Am J Psychiatry. May, 1997; 154(5); 630-4

• 1997 -- Pubmed # 9262939 Haggerty Jr, J. J., Silva, S. G., Marquardt, M., Mason, G. A., Chang, H. Y., Evans, D. L., Golden, R. N., Pedersen, C. Prevalence of antithyroid antibodies in mood disorders. Depress Anxiety. 1997; 5(2); 91-6

• 1997 -- Janowsky, D. S., Morter, S., Hong, L. L., Howe L. L., Silva S. G. Myers Briggs Type Indicator differences between major depressive, bipolar, and alcohol/substance disorder patients and normals. In Mind, Body, and Personality: The Role of Type in Mental and Physical Health - Proceedings, edited by 1997; pp. 37-44. Gainesville FL: Center for Applications of Psychological Type.

• 1997 -- Cheong, J. A., Silva, S. G., Petitto, J. M., Herkov, M. J., Evans, D. L. Human immunodeficiency virus-related psychopathology and treatment. In Current Psychiatric Therapy II, edited by Dunner, D. L. 1997; pp. 521-528. Philadelphia: W. B Saunders.

• 1996 -- Pubmed # 8789912 Gilmore, J. H., Perkins, D. O., Kliewer, M. A., Hage, M. L., Silva, S. G., Chescheir, N. C., Hertzberg, B. S., Sears, C. A. Fetal brain development of twins assessed in utero by ultrasound: implications for schizophrenia. Schizophr Res. May, 1996; 19(2-3); 141-9

• 1996 -- Pubmed # 8639064 Stern, R. A., Silva, S. G., Chaisson, N., Evans, D. L. Influence of cognitive reserve on neuropsychological functioning in asymptomatic human immunodeficiency virus-1 infection. Arch Neurol. February, 1996; 53(2); 148-53

• 1996 -- Pubmed # 8742115 Stabler, B., Clopper, R. R., Siegel, P. T., Nicholas, L. M., Silva, S. G., Tancer, M. E., Underwood, L. E. Links between growth hormone deficiency, adaptation and social phobia. Horm Res. 1996; 45(1-2); 30-3

• 1995 -- Pubmed # 7727629 Stern, R. A., Whealin, J. M., Mason, G. A., Noonan, L. R., Silva, S. G., Arruda, J. E., Prange Jr, A. J. Influence of L-triiodothyronine on memory following repeated electroconvulsive shock in rats: implications for human electroconvulsive therapy. Biol Psychiatry. February, 1995; 37(3); 198-201

• 1995 -- Pubmed # 7695885 Lewis, M. H., Silva, J. R., Silva, S. Cyclicity of aggression and self-injurious behavior in individuals with mental retardation. Am J Ment Retard. January, 1995; 99(4); 436-44

• 1995 -- Garbutt, J. C., Silva, S. G., Mason, G. A. Thyrotropin-releasing hormone (TRH): Clinical neuroendocrine and neurobehavioral findings of relevance to alcoholism. In Drug and Alcohol Abuse Reviews: Volume 6: Alcohol and Hormones, edited by R. R. Watson 1995; pp. 127-145. New York: Humana Press.

• 1992 -- Pubmed # 1636810 Stern, R. A., Singer, N. G., Silva, S. G., Rogers, H. J., Perkins, D. O., Hall, C. D., van der Horst, C. M., Evans, D. L. Neurobehavioral functioning in a nonconfounded group of asymptomatic HIV-seropositive homosexual men. Am J Psychiatry. August, 1992; 149(8); 1099-102

• 1992 -- Pubmed # 1534002 Evans, D. L., Folds, J. D., Petitto, J. M., Golden, R. N., Pedersen, C. A., Corrigan, M., Gilmore, J. H., Silva, S. G., Quade, D., Ozer, H. Circulating natural killer cell phenotypes in men and women with major depression. Relation to cytotoxic activity and severity of depression. Arch Gen Psychiatry. April, 1992; 49(5); 388-95

• 1989 -- Pubmed # 2736070 LeVere, T. E., Brugler, T., Sandin, M., Gray-Silva, S. Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine. Behav Neurosci. June, 1989; 103(3); 561-5

• 1989 -- Gray-Silva, S. L., Appelbaum, M. I. The Awards Committee for Education: A retrospective study. Research Memorandum No. 83. 1989;

• 1989 -- Gray-Silva, S. L., Appelbaum, M. I. North Carolina At Risk Study - Phase 2: Interviews with high school dropouts. Research Memorandum No. 82. 1989;

• 1989 -- Gray-Silva, S. L., Appelbaum, M. I. 1987 SAT profiles of college-bound seniors in North Carolina. Research Memorandum No. 81. 1989;

• 1989 -- Gray-Silva, S. L., Appelbaum, M. I. North Carolina At Risk Study - Phase 2. Research Memorandum No. 78. 1989;

• 1988 -- LeVere, N. D., Gray-Silva, S. L., LeVere, T. E. Infant brain injury: The benefit of relocation and the cost of crowding. In Brain Injury and Recovery, edited by S. Finger, T. E. LeVere, C. R. Almli, & D. G. Stein 1988; pp. 133-150. New York: Plenum.

• 1986 -- Pubmed # 3964431 Means, L. W., Gray, S. L., Medlin, C. W. Prenatal ethanol exposure fails to affect stimulus reactivity in the rat. Alcohol. June, 1986; 3(1); 1-4

• 1986 -- Pubmed # 3703090 Means, L. W., Russ, R. D., Medlin, C. W., Gray, S. L. Prenatal ethanol exposure in rats does not alter maze exploration or impair visual discrimination with or without distracting stimuli. Neurobehav Toxicol Teratol. June, 1986; 8(1); 1-5

• 1984 -- Pubmed # 6493422 Means, L. W., Medlin, C. W., Hughes, V. D., Gray, S. L. Hyperresponsiveness to methylphenidate in rats following prenatal ethanol exposure. Neurobehav Toxicol Teratol. December, 1984; 6(3); 187-92

• 1984 -- Means, L. W., Medlin, C. W., Russ, R. D., Higgins, J. L., Gray, S. L. Shock-induced aggression is not affected by prenatal exposure to ethanol. IRCS Medical Science. 1984; 12 177

• 1981 -- Means, L. W., Adams, J. M., Gray, S. L. The effects of fetal ethanol exposure on adult discrimination reversal in rats. IRCS Medical Science. 1981; 9 1092

• 1981 -- Gray, S. L., Potts, F. L.,, Means, L. W. Failure of neonatal ethanol exposure to impair maze acquisition in rats IRCS Medical Science. 1981; 9 16

Grant Funding (selected)

• The Development of an Online Learning System for Understanding Research Design and Analysis Concepts  
  Duke University SON CONCEPT Office CATALYST Award
  07/2014-06/2015
  Role: PI
  Project Goals: The goal of the project is to develop a non-linear interactive online system in which all concepts related to research design and analysis are displayed at once with each one representing a distinct node in a web of ideas, with the effect being similar to the look and feel of Prezi presentations. Each node will be a brief 15-minute overview with animated slides and voiceover narration describing the concept. The learner may then choose to move up to a more basic description, down to a more in-depth discussion, or sideways to learn more about related concepts and their connections to the original concept. The system will be used as an online resource for design and analysis courses and may be integrated across the ABSN, MSN (e.g. Scholarly Dimensions I and II courses) and PhD programs as a supplemental tool to enhance understanding of research concepts.

• Unmasking Cognitive Deficits After Recovery from Mild Traumatic Brain Injury  
  Uniformed Services University of the Health Services
  HU0001-11-1-TS07 N11-P15
  08/2011-07/2014
  Role: Co-investigator
  Project Goal: The purpose of the study is to examine the use of mild hypoxia as a clinical tool to uncover latent cognitive defects after apparent recovery from a mild traumatic brain injury.

• Substance Use Outcomes Following Treatment for Adolescent Depression (SOFTAD)  
  National Institute of Mental Heath
  5R01MH070494-05
  09/2003-05/2010
  Role: Statistical Principal Investigator
  

• Child and Adolescent Psychiatry Trials Network (CAPTN)  
  National Institute of Mental Health
  1P30MH066386-01A1
  09/2003-07/2008
  Role: Statistical Principal Investigator
  

• Treatment for Adolescents with Depression Study (TADS)  
  National Institute of Mental Health
  07/1999-07/2008
  Role: Statistical Principal Investigator
  

• Safety and Efficacy of Sertraline for Depression in Congestive Heart Failure (SADHART-CHF)  
  National Institute of Mental Health
  1R01MH063211-01A2
  02/2003-01/2008
  Role: Statistical Investigator
  

• Dynamic Outcome Assessment in Multi Center Trials (PROMIS)  
  National Institute of Mental Health
  1U01AR052186-01
  09/2004-07/2009
  Role: Co-investigator
  

• Anxiety, Depression, and Non-Cardiac Chest Pain (NCCP)  
  National Institute of Mental Health
  5R01MH063429-05
  04/2001-03/2007
  Role: Statistical Principal Investigator
  

• National Center for Child Traumatic Stress  
  SAMHSA
  07/2001-07/2003
  Role: Co-Investigator
  

• Cooperative Multi-Center Reproductive Medicine Network: Data and Statistical Coordinating Center  
  National Institute of Child Health and Human Development (NICHD)
  1U01HD038997-01
  03/2000-02/2005
  Role: Statistical Principal Investigator
  

• National Drug Abuse Treatment Clinical Trials Network  
  National Institute of Drug Abuse
  1U10DA013711-01
  01/2001-12/2005
  Role: Statistical Principal Investigator
  

• Anxiety and Vagal Control of the Heart in Coronary Artery Disease  
  National Institute of Mental Health
  07/1999-06/2000
  Role: Co-Investigator
  

• Neuroscience of Mental and Behavioral Disorders Mental Health and Neuroscience Clinical Research Center: Data Management and Biostatistics Core  
  National Institute of Mental Health
  2P30MH033127-19
  07/1997-06/1999
  Role: Core Associate Director and Co-Investigator
  

• Neuroscience of Mental and Behavioral Disorders: Mental Health and Neuroscience Clinical Research Center: Behavioral and Cognitive Neuroscience Core  
  National Institute of Mental Health
  2P30MH033127-19
  07/1997-06/1999
  Role: Core Director and Co-Investigator
  

• Neuroimaging in HIV Infection  
  National Institute of Mental Health
  07/1997-06/1999
  Role: Co-Investigator
  

• Risperidone and Clozapine in Chronic Schizophrenia - Child Supplement  
  National Institute of Mental Health
  07/1996-06/1999
  Role: Co-Investigator
  

• Effects of HIV on the Nervous System in Women  
  National Institute of Neurologic Disorders and Stroke
  07/1995-06/1999
  Role: Co-Investigator
  

• Neuropsychiatric Functioning in Women with Subclinical Hypothyroidism  
  Foundation of Hope for Research and Treatment of Mental Illness
  07/1995-06/1999
  Role: PI
  

• HIV: Neuropsychiatric and Psychoimmune Relationships  
  National Institute of Mental Health
  07/1995-06/1999
  Role: Co-Investigator
  

• The Effects of Physostigmine on Neuropsychological Neuroendocrine Functioning in Subjects at High Risk for Major Depression  
  National Alliance for Research on Schizophrenia and Depression
  07/1994-06/1997
  Role: PI
  

• Effects of High-Dose Intravenous Thyrotropin-Releasing Hormone (TRH) on Craving for Alcohol in Abstinent AlcoholicMen and Women  
  Foundation of Hope for Research and Treatment of Mental Illness
  07/1993-06/1995
  Role: Co-Investigator
  

• Psychoendocrinology: Children and Adults Mental Health Clinical Research Center: Neurobehavioral Assessment Core  
  National Institute of Mental Health
  07/1992-06/1997
  Role: Director and Co-Principal Investigator
  

• Psychoendocrinology: Children and Adults Mental Health Clinical Research: Data Management and Biostatistics Core  
  National Institute of Mental Health
  07/1992-06/1997
  Role: Co-Investigator
  

• The Effects of Physostigmine on Cognition, Mood, and Neuroendocrine Functioning in Healthy Subjects at High Risk for Major Depression  
  Medical Faculty Research Grants Committee, University of North Carolina School of Medicine
  07/1991-06/1992
  Role: PI
  

• Physostigmine as a Psychodiagnostic Tool: The Effects of Physostigmine on Cognition, Mood, and Behavior  
  The North Carolina Foundation for Mental Health Research, Inc.
  07/1990-06/1991
  Role: Co-Principal Investigator
  

• HIV: Neuropsychiatric and Psychoimmune Relationships  
  National Institute of Mental Health
  07/1991-06/1995
  Role: Co-Investigator