Charles A. Gersbach, Assistant Professor  


Charles A. Gersbach
Contact Info:
Office Location:  2123 CIEMAS
Office Phone:  (919) 613-2147
Email Address:   send me a message
Web Page: http://gersbach.bme.duke.edu/

Education:

Postdoctoral Fellow, The Scripps Research Institute, 2009
PhD, Georgia Institute of Technology and Emory University, 2006
BS, Georgia Institute of Technology, 2001
Research Interests:

Dr. Gersbach’s research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Areas of Interest:

Gene therapy for hereditary disorders and tissue regeneration
Methods for gene delivery and targeted genome modification
Engineering therapeutic proteins and biomolecules
Controlling cellular behavior and tissue growth with synthetic gene circuits

Specialties:

Drug Delivery
Genomics
Tissue Repair, Tissue Engineering
Polymer and Protein Engineering
Biological Materials
Awards, Honors, and Distinctions

Capers and Marion McDonald Award for Excellence in Teaching and Research, 2013
NSF Faculty Early Career Development (CAREER) Award, 2012
Basil O'Connor Starter Scholar Research Award, March of Dimes, 2011
NIH Director's New Innovator Award, 2011
Ralph E. Powe Junior Faculty Enhancement Award, Oak Ridge Associated Universities, 2011
Scientist Development Grant, American Heart Association, 2010
Hartwell Individual Biomedical Research Award, 2009
National Cancer Institute Postdoctoral Fellowship, 2007-2009
F.L. Suddath Memorial Award, 2005
National Institutes of Health National Research Service Award, 2002-2004
Georgia Institute of Technology President’s Scholarship, 1998
Teaching (Spring 2025):

  • BME 564L.001, GENOME ENGINEERING LAB Synopsis
    Wilkinson 136, TuTh 10:05 AM-11:20 AM
  • BME 564L.01L, GENOME ENGINEERING LAB Synopsis
    Teer 0005, F 01:25 PM-04:25 PM
Teaching (Fall 2025):

  • BME 562.01, BIOLOGY BY DESIGN Synopsis
    Fitzpatrk 1464, TuTh 10:05 AM-11:20 AM
Representative Publications   (More Publications)

  1. P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, LR Polstein, PI Thakore, KA Glass, DG Ousterout, KW Leong, F Guilak, GE Crawford, TE Reddy, CA Gersbach, RNA-Guided Gene Activation by CRISPR-Cas9-Based Transcription Factors, Nature Methods (2013) .
  2. DG Ousterout, P Perez-Pinera, PI Thakore, AM Kabadi, MT Brown, X Qin, O Fredrigo, V Mouly, JP Tremblay, CA Gersbach, Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells from Duchenne Muscular Dystrophy Patients, Molecular Therapy, vol. 21 no. 9 (2013), pp. 1718-26 .
  3. P. Perez-Pinera, D.G. Ousterout, J.M. Brunger, A.M. Farin, K.A. Glass, F. Guilak, G.E. Crawford, A.J. Hartemink, C.A. Gersbach, Synergistic and Tunable Human Gene Activation by Combinations of Engineered Transcription Factors, Nature Methods, vol. 10 no. 3 (2013), pp. 239-42 .
  4. L.R. Polstein and C.A. Gersbach, Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors, Journal of the American Chemical Society, vol. 134 no. 40 (2012), pp. 16480-3 .
  5. P. Perez-Pinera, D.G. Ousterout, and C.A. Gersbach, Advances in targeted genome editing, Current Opinion in Chemical Biology, vol. 16 no. 3-4 (2012), pp. 268-77 .
  6. C.A. Gersbach, T. Gaj, R.M. Gordley, A.C. Mercer, and C.F. Barbas, III., Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase, Nucleic Acids Research, vol. 39 no. 17 (2011), pp. 7868-78 .
  7. R.M. Gordley, C.A. Gersbach, and C.F. Barbas, III, Synthesis of programmable integrases, Proceedings of the National Academy of Sciences USA, vol. 106 no. 13 (2009), pp. 5053-8 .
  8. C. A. Gersbach, S. R. Coyer, J. M. Le Doux, and A. J. Garcia, Biomaterial-mediated retroviral gene transfer using self-assembled monolayers, Biomaterials, vol. 28 no. 34 (2007), pp. 5121 - 5127 .