Charles A Gersbach, Assistant Professor  


Charles A Gersbach
Contact Info:
Office Location:  1089 Medical Sciences Research Building II
Office Phone:  919-684-1129
Email Address:   send me a message
Web Page: http://gersbach.bme.duke.edu/

Education:

Postdoctoral Fellow, The Scripps Research Institute, 2009
PhD, Georgia Institute of Technology and Emory University, 2006
BS, Georgia Institute of Technology, 2001
Research Interests:

Dr. Gersbach’s research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Areas of Interest:

Gene therapy for hereditary disorders and tissue regeneration
Methods for gene delivery and targeted genome modification
Engineering therapeutic proteins and biomolecules
Controlling cellular behavior and tissue growth with synthetic gene circuits

Specialties:

Drug Delivery
Genomics
Tissue Repair, Tissue Engineering
Polymer and Protein Engineering
Biological Materials
Awards, Honors, and Distinctions

Basil O'Connor Starter Scholar Research Award, March of Dimes, 2011
NIH Director's New Innovator Award, 2011
Ralph E. Powe Junior Faculty Enhancement Award, Oak Ridge Associated Universities, 2011
Scientist Development Grant, American Heart Association, 2010
Hartwell Individual Biomedical Research Award, 2009
National Cancer Institute Postdoctoral Fellowship, 2007-2009
F.L. Suddath Memorial Award, 2005
National Institutes of Health National Research Service Award, 2002-2004
Georgia Institute of Technology President’s Scholarship, 1998
Teaching (Spring 2012):

  • BME 100L.02, MODELS CELL & MOL SYSTEMS Synopsis
    Hudson 207, MW 10:05 AM-11:20 AM
  • BME 100L.03L, MODELS CELL & MOL SYSTEMS Synopsis
    Teer P013, Tu 01:15 PM-03:15 PM
  • BME 100L.04L, MODELS CELL & MOL SYSTEMS Synopsis
    Teer P013, Tu 04:25 PM-06:25 PM
  • ME 302.01, BIOLOGICAL ENGINEERING SEM Synopsis
    CIEMAS 1466, Th 04:25 PM-05:25 PM
Representative Publications   (More Publications)

  1. C.A. Gersbach, T. Gaj, R.M. Gordley, and C.F. Barbas, III., Directed evolution of recombinase specificity by split gene reassembly, Nucleic Acids Research, vol. 38 no. 12 (2010), pp. 4198-206 .
  2. R.M. Gordley, C.A. Gersbach, and C.F. Barbas, III, Synthesis of programmable integrases, Proceedings of the National Academy of Sciences USA, vol. 106 no. 13 (2009), pp. 5053-8 .
  3. C. A. Gersbach, S. R. Coyer, J. M. Le Doux, and A. J. Garcia, Biomaterial-mediated retroviral gene transfer using self-assembled monolayers, Biomaterials, vol. 28 no. 34 (2007), pp. 5121 - 5127 .
  4. C. A. Gersbach, R. E. Guldberg, and A. J. Garcia, In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts, Journal of Cellular Biochemistry, vol. 100 no. 5 (2007), pp. 1324 - 1336 .
  5. C. A. Gersbach, J. M. Le Doux, R. E. Guldberg, and A. J. Garcia, Inducible regulation of Runx2-stimulated osteogenesis, Gene Therapy, vol. 13 no. 11 (2006), pp. 873 - 882 .
  6. M. A. Lan, C. A. Gersbach, K. E. Michael, B. G. Keselowsky, and A. J. Garcia, Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries, Biomaterials, vol. 26 no. 22 (2005), pp. 4523 - 4531 .
  7. C. A. Gersbach, B. A. Byers, G. K. Pavlath, and A. J. Garcia, Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype, Experimental Cell Research, vol. 300 no. 2 (2004), pp. 406 - 417 .