Papers Published

1. M. Hunter and V. Backman and G. Popescu and M. Kalashnikov and C. W. Boone and A. Wax and V. Gopal and K. Badizadegan and G. D. Stoner and M. S. Feld, Tissue self-affinity and polarized light scattering in the Born approximation: A new model for precancer detection, Physical Review Letters, vol. 97 no. 13 (September, 2006) .
   (last updated on 2009/09/02)

   Abstract:
   Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats. Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.