Papers Published

1. Muller, M.G. and Wax, A. and Georgakoudi, I. and Dasari, R.R. and Feld, M.S., A reflectance spectrofluorimeter for real-time spectral diagnosis of disease, Rev. Sci. Instrum. (USA), vol. 73 no. 11 (2002), pp. 3933 - 7 [1.1511795] .
   (last updated on 2007/04/14)

   Abstract:
   We have developed a portable multiexcitation dye laser system pumped by a 308 nm excimer laser, which can collect fluorescence spectra at 11 excitation wavelengths and a white light reflectance spectrum in less than 200 ms. The system is designed to be used in a hospital setting for in vivo tissue analysis based on fluorescence and reflectance spectroscopy. A specially designed optical fiber probe with SMA couplers facilitates easy alignment, important in a clinical setting. An intensified charge coupled device camera provides fast data acquisition with large signal-to-noise (S/N) ratio. The optical and electronic systems are controlled with LABVIEW, which is well suited for real time analysis, to extract diagnostic information. We present typical spectra that demonstrate the large excitation-emission wavelength range over which spectra can be acquired with very good S/N ratios

   Keywords:
   biological tissues;data analysis;dye lasers;excimer lasers;fibre optic sensors;fluorescence;laser applications in medicine;medical image processing;patient diagnosis;portable instruments;real-time systems;spectroscopy computing;