Papers Published

1. Mueller, M.G. and Georgakoudi, I. and Wax, A. and Dasari, R.R. and Jost, C. and Wallace, M.B. and Feld, M.S., Multiexcitation fluorescence and reflectance spectroscopy as a real-time guide to biopsy in vivo, Proc. SPIE - Int. Soc. Opt. Eng. (USA), vol. 4261 (2001), pp. 114 - 21 [12.424525] .
   (last updated on 2007/04/14)

   Abstract:
   A compact excitation-emission spectrofluorimeter system used to acquire tissue fluorescence and reflectance with fiber optic light delivery and collection is presented. Ten dye cells are pumped by a XeCl excimer laser, creating laser excitation from 308 nm to 505 nm, which is used to excite tissue fluorescence. A xenon-flash lamp is employed to obtain the reflectance spectrum of the corresponding tissue spot. Eleven fluorescence spectra and one white light diffuse reflectance spectrum are collected in vivo in 0.2 seconds and can be potentially analyzed in real time to obtain diagnostic information. The instrument can be used for early cancer detection

   Keywords:
   biochemistry;biological tissues;cancer;cellular biophysics;fluorescence;laser applications in medicine;light scattering;molecular biophysics;optical fibres;patient diagnosis;proteins;reflectivity;visible spectroscopy;