Papers Published

1. Muzikant, AL; Henriquez, CS, Bipolar stimulation of a three-dimensional bidomain incorporating rotational anisotropy., Ieee Transactions on Bio Medical Engineering, vol. 45 no. 4 (April, 1998), pp. 449-462 [9556962], [doi] .
   (last updated on 2023/06/01)

   Abstract:
   A bidomain model of cardiac tissue was used to examine the effect of transmural fiber rotation during bipolar stimulation in three-dimensional (3-D) myocardium. A 3-D tissue block with unequal anisotropy and two types of fiber rotation (none and moderate) was stimulated along and across fibers via bipolar electrodes on the epicardial surface, and the resulting steady-state interstitial (phi e) and transmembrane (Vm) potentials were computed. Results demonstrate that the presence of rotated fibers does not change the amount of tissue polarized by the point surface stimuli, but does cause changes in the orientation of phi e and Vm in the depth of the tissue, away from the epicardium. Further analysis revealed a relationship between the Laplacian of phi e, regions of virtual electrodes, and fiber orientation that was dependent upon adequacy of spatial sampling and the interstitial anisotropy. These findings help to understand the role of fiber architecture during extracellular stimulation of cardiac muscle.

   Keywords:
   bioelectric phenomena;biomembranes;cardiology;electrodes;muscle;physiological models;