Faculty - Duke BME

Charles A Gersbach, Assistant Professor

Office Location:	1089 Medical Sciences Research Building II
Office Phone:	919-684-1129
Email Address:
Web Page:

Education:: Postdoctoral Fellow, The Scripps Research Institute, 2009; PhD, Georgia Institute of Technology and Emory University, 2006; BS, Georgia Institute of Technology, 2001

Specialties:: Drug Delivery
Genomics
Tissue Repair, Tissue Engineering
Polymer and Protein Engineering
Biological Materials

Research Interests:: Dr. Gersbach’s research interests are in gene therapy, biomolecular and cellular engineering, regenerative medicine, and synthetic biology.

Areas of Interest:: Gene therapy for hereditary disorders and tissue regeneration
Methods for gene delivery and targeted genome modification
Engineering therapeutic proteins and biomolecules
Controlling cellular behavior and tissue growth with synthetic gene circuits

Awards, Honors, and Distinctions: Georgia Institute of Technology President’s Scholarship, 1998-2001
National Institutes of Health National Research Service Award, 2002-2004
National Cancer Institute Postdoctoral Fellow, 2007-2009

Representative Publications (More Publications)

R.M. Gordley, C.A. Gersbach, and C.F. Barbas, III, Synthesis of programmable integrases, Proceedings of the National Academy of Sciences USA, vol. 106 no. 13 (2009), pp. 5053-8 .
C. A. Gersbach, S. R. Coyer, J. M. Le Doux, and A. J. Garcia, Biomaterial-mediated retroviral gene transfer using self-assembled monolayers, Biomaterials, vol. 28 no. 34 (2007), pp. 5121 - 5127 .
C. A. Gersbach, R. E. Guldberg, and A. J. Garcia, In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts, Journal of Cellular Biochemistry, vol. 100 no. 5 (2007), pp. 1324 - 1336 .
C. A. Gersbach, J. M. Le Doux, R. E. Guldberg, and A. J. Garcia, Inducible regulation of Runx2-stimulated osteogenesis, Gene Therapy, vol. 13 no. 11 (2006), pp. 873 - 882 .
M. A. Lan, C. A. Gersbach, K. E. Michael, B. G. Keselowsky, and A. J. Garcia, Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries, Biomaterials, vol. 26 no. 22 (2005), pp. 4523 - 4531 .
C. A. Gersbach, B. A. Byers, G. K. Pavlath, and A. J. Garcia, Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype, Experimental Cell Research, vol. 300 no. 2 (2004), pp. 406 - 417 .