publications by Charles A. Gersbach.


Papers Published

  1. P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, LR Polstein, PI Thakore, KA Glass, DG Ousterout, KW Leong, F Guilak, GE Crawford, TE Reddy, CA Gersbach, RNA-Guided Gene Activation by CRISPR-Cas9-Based Transcription Factors, Nature Methods (2013) .
  2. DG Ousterout, P Perez-Pinera, PI Thakore, AM Kabadi, MT Brown, X Qin, O Fredrigo, V Mouly, JP Tremblay, CA Gersbach, Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells from Duchenne Muscular Dystrophy Patients, Molecular Therapy, vol. 21 no. 9 (2013), pp. 1718-26 .
  3. T Gaj, CA Gersbach, CF Barbas, III, ZFN, TALEN and CRISPR/Cas-Based Methods for Genome Engineering, Trends in Biotechnology, vol. 31 no. 7 (2013), pp. 397-405 .
  4. DW Dumbauld, TT Lee, A Singh, J Scrimgeour, CA Gersbach, EA Zamir, J Fu, CS Chen, JE Curtis, SW Craig, AJ García, How Vinculin Regulates Force Transmission, Proc. Natl. Acad. Sci. USA, vol. 110 no. 24 (2013), pp. 9788-93 .
  5. P. Perez-Pinera, D.G. Ousterout, J.M. Brunger, A.M. Farin, K.A. Glass, F. Guilak, G.E. Crawford, A.J. Hartemink, C.A. Gersbach, Synergistic and Tunable Human Gene Activation by Combinations of Engineered Transcription Factors, Nature Methods, vol. 10 no. 3 (2013), pp. 239-42 .
  6. T.M. Gibson and C.A. Gersbach, The role of single-cell analyses in understanding cell lineage commitment, Biotechnology Journal, vol. 8 no. 4 (2013), pp. 397-407 .
  7. L.R. Polstein and C.A. Gersbach, Light-inducible spatiotemporal control of gene activation by customizable zinc finger transcription factors, Journal of the American Chemical Society, vol. 134 no. 40 (2012), pp. 16480-3 .
  8. P. Perez-Pinera, D.G. Ousterout, and C.A. Gersbach, Advances in targeted genome editing, Current Opinion in Chemical Biology, vol. 16 no. 3-4 (2012), pp. 268-77 .
  9. P. Perez-Pinera, D.G. Ousterout, M.T. Brown, and C.A. Gersbach, Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases, Nucleic Acids Research, vol. 40 no. 8 (2012), pp. 3741-52 .
  10. M.S. Bhakta, I.M. Henry, D.G. Ousterout, K.T. Das, S.H. Lockwood, J.F. Meckler, M.C. Wallen, A. Zykovich, Y. Yu, H. Leo, L. Xu, C.A. Gersbach, D.J. Segal., Highly Active Zinc Finger Nucleases by Extended Modular Assembly, Genome Research (2012) .
  11. C.A. Gersbach, T. Gaj, R.M. Gordley, A.C. Mercer, and C.F. Barbas, III., Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase, Nucleic Acids Research, vol. 39 no. 17 (2011), pp. 7868-78 .
  12. T. Gaj, A.C. Mercer, C.A. Gersbach, R.M. Gordley, and C.F. Barbas, III, Structure-guided reprogramming of serine recombinase specificity, Proceedings of the National Academy of Sciences USA, vol. 108 no. 2 (2011), pp. 498-503 .
  13. C.A. Gersbach, T. Gaj, R.M. Gordley, and C.F. Barbas, III., Directed evolution of recombinase specificity by split gene reassembly, Nucleic Acids Research, vol. 38 no. 12 (2010), pp. 4198-206 .
  14. R.M. Gordley, C.A. Gersbach, and C.F. Barbas, III, Synthesis of programmable integrases, Proceedings of the National Academy of Sciences USA, vol. 106 no. 13 (2009), pp. 5053-8 .
  15. C. A. Gersbach, J. E. Phillips, and A. J. Garcia, Genetic engineering for skeletal regenerative medicine, Annual Review of Biomedical Engineering, vol. 9 (2007), pp. 87 - 119 .
  16. S. Pregizer, A. Barski, C. A. Gersbach, A. J. Garcia, and B. Frenkel, Identification of novel Runx2 targets in osteoblasts: Cell type-specific BMP-dependent regulation of Tram2, Journal of Cellular Biochemistry, vol. 102 no. 6 (2007), pp. 1458 - 1471 .
  17. C. A. Gersbach, S. R. Coyer, J. M. Le Doux, and A. J. Garcia, Biomaterial-mediated retroviral gene transfer using self-assembled monolayers, Biomaterials, vol. 28 no. 34 (2007), pp. 5121 - 5127 .
  18. C. A. Gersbach, R. E. Guldberg, and A. J. Garcia, In vitro and in vivo osteoblastic differentiation of BMP-2- and Runx2-engineered skeletal myoblasts, Journal of Cellular Biochemistry, vol. 100 no. 5 (2007), pp. 1324 - 1336 .
  19. J. E. Phillips, C. A. Gersbach, and A. J. Garcia, Virus-based gene therapy strategies for bone regeneration, Biomaterials, vol. 28 no. 2 (2007), pp. 211 - 229 .
  20. C. A. Gersbach, J. M. Le Doux, R. E. Guldberg, and A. J. Garcia, Inducible regulation of Runx2-stimulated osteogenesis, Gene Therapy, vol. 13 no. 11 (2006), pp. 873 - 882 .
  21. J. E. Phillips, C. A. Gersbach, A. M. Wojtowicz, and A. J. Garcia, Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation, Journal of Cell Science, vol. 119 no. 3 (2006), pp. 581 - 591 .
  22. M. A. Lan, C. A. Gersbach, K. E. Michael, B. G. Keselowsky, and A. J. Garcia, Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries, Biomaterials, vol. 26 no. 22 (2005), pp. 4523 - 4531 .
  23. C. A. Gersbach, B. A. Byers, G. K. Pavlath, and A. J. Garcia, Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype, Experimental Cell Research, vol. 300 no. 2 (2004), pp. 406 - 417 .
  24. C. A. Gersbach, B. A. Byers, G. K. Pavlath, R. E. Guldberg, and A. J. Garcia, Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro, Biotechnology and Bioengineering, vol. 88 no. 3 (2004), pp. 369 - 378 .
  25. A. J. Garcia, R. E. Guldberg, B. J. Byers, C. A. Gersbach, and J. E. Phillips, Addressing cell-sourcing limitations with gene therapy, IEEE Engineering in Medicine and Biology Magazine, vol. 22 no. 5 (2003), pp. 65 - 70 .