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Mark W Dewhirst, Professor of Radiation Oncology and Biomedical Engineering  


Mark W Dewhirst
Contact Info:
Office Location:  201 Med Sci Res Bldg
Email Address:   send me a message
Web Page: http://www.radonc.duke.edu/department/academ/div/cancerbio/faculty/dewhirst.html

Education:

Ph.D., Colorado State University, 1979
Specialties:

Medical Imaging
Representative Publications   (More Publications)

  1. MW Dewhirst, Mechanisms underlying hypoxia development in tumors., Advances in experimental medicine and biology, United States, vol. 510 (2003), pp. 51-6 .
  2. Dewhirst MW: Considerations for hyperthermia clinical trial designs. In MH Seegenschmiedt, P Fessenden and CC Vernon (eds.), Principles and Practice of Thermoradiotherapy and Thermochemotherapy. Berlin: Springer-Verlag, 1996. Vol. II, pp 361-372. .
  3. AC Lockhart, RD Braun, D Yu, JR Ross, MW Dewhirst, JS Humphrey, S Thompson, KM Williams, B Klitzman, F Yuan, JM Grichnik, AD Proia, DA Conway, HI Hurwitz, Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor., Clinical cancer research : an official journal of the American Association for Cancer Research, United States, vol. 9 no. 2 (February, 2003), pp. 586-93  [abs].
  4. Dewhirst MW and Needham D: Extravasation of Stealth¨ liposomes into tumors: Direct measurement of accumulation and vascular permeability using a skin-flap window chamber. In D Lasic and F Martin (eds.), Stealth¨ Liposomes, Boca Raton: CRC Press, 1995. Pp 127-137. .
  5. RA Richardson, MW Dewhirst, The effect of nicotinamide & hyperoxic gases on blood glucose., Advances in experimental medicine and biology, United States, vol. 510 (2003), pp. 375-8 .
  6. Dewhirst MW: Thermal dosimetry. In MH Seegenschmiedt, P Fessenden and CC Vernon (eds.), Principles and Practice of Thermoradiotherapy and Thermochemotherapy. Berlin: Springer-Verlag, 1995. Vol. I, pp 123-136. .
  7. Z Vujaskovic, I Batinic-Haberle, ZN Rabbani, QF Feng, SK Kang, I Spasojevic, TV Samulski, I Fridovich, MW Dewhirst, MS Anscher, A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury., Free radical biology & medicine, United States, vol. 33 no. 6 (September, 2002), pp. 857-63  [abs].
  8. Dewhirst MW, Madwed D, Meyer RE, Ong, ET, Klitzman B, Rosner GL, Dodge R: Reduction in tumor blood flow in skin flap tumor after hydralazine is not due to a vascular steal phenomenon. Radiation Oncology Investigations 1:270-278, 1994. .
  9. BD Kavanagh, TW Secomb, R Hsu, PS Lin, J Venitz, MW Dewhirst, A theoretical model for the effects of reduced hemoglobin-oxygen affinity on tumor oxygenation., International journal of radiation oncology, biology, physics, United States, vol. 53 no. 1 (May, 2002), pp. 172-9  [abs].
  10. Prescott DM, Charles HC, Sostman HD, Dodge RK, Thrall DE, Page RL, Tucker JA, Harrelson JM, Leopold KA, Oleson JR, Dewhirst MW: Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy. International Journal Radiation Oncology Biology Physics 28:415-423, 1994. .
  11. LP Hale, RD Braun, WM Gwinn, PK Greer, MW Dewhirst, Hypoxia in the thymus: role of oxygen tension in thymocyte survival., American journal of physiology. Heart and circulatory physiology, United States, vol. 282 no. 4 (April, 2002), pp. H1467-77  [abs].
  12. Anscher MS, Montana GS, Dodge R, Gaydica E, Dewhirst MW, Prosnitz LR: The lack of impact of treatment time on the outcome of definitive radiotherapy for carcinoma of the prostate. International Journal of Oncology 3:707-711, 1993. .
  13. CW Wong, C Song, MM Grimes, W Fu, MW Dewhirst, RJ Muschel, AB Al-Mehdi, Intravascular location of breast cancer cells after spontaneous metastasis to the lung., The American journal of pathology, United States, vol. 161 no. 3 (September, 2002), pp. 749-53  [abs].
  14. Castellino S, Elion GB, Griffith OW, Dewhirst M, Kurtzberg J, Cattley RC, Scott P, Bigner DD, Friedman HS: Development of a model of melphalan-induced gastrointestinal toxicity in mice. Cancer Chemotherapy and Pharmacology 31:376-380, 1993. .
  15. JR Dynlacht, MW Dewhirst, EJ Hall, BS Rosenstein, EM Zeman, Toward a consensus on radiobiology teaching to radiation oncology residents., Radiation research, United States, vol. 157 no. 5 (May, 2002), pp. 599-606  [abs].
  16. Dewhirst MW: Mechanisms of hyperthermic cytotoxicity and effects at the tissue level. In RB Roemer (ed.), HTD-Vol. 268, Advances in Bioheat and Mass Transfer 1993. New York: The American Society of Mechanical Engineers, 1993. .
  17. EM Zeman, JR Dynlacht, BS Rosenstein, MW Dewhirst, ASTRO Joint Working Group on Radiobiology Teaching, Toward a national consensus: teaching radiobiology to radiation oncology residents., International journal of radiation oncology, biology, physics, United States, vol. 54 no. 3 (November, 2002), pp. 861-72  [abs].
  18. Dewhirst MW: Angiogenesis and blood flow in solid tumors. In BA Teicher (ed.), Drug Resistance in Oncology. New York: Marcel Dekker, Inc., 1993. Pp 3-24. .
  19. BW Pogue, RD Braun, JL Lanzen, C Erickson, MW Dewhirst, Analysis of the heterogeneity of pO2 dynamics during photodynamic therapy with verteporfin., Photochemistry and photobiology, United States, vol. 74 no. 5 (November, 2001), pp. 700-6  [abs].
  20. G Kong, RD Braun, MW Dewhirst, Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature., Cancer research, United States, vol. 61 no. 7 (April, 2001), pp. 3027-32  [abs].
  21. CE Connor, JD Norris, G Broadwater, TM Willson, MM Gottardis, MW Dewhirst, DP McDonnell, Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor., Cancer research, United States, vol. 61 no. 7 (April, 2001), pp. 2917-22  [abs].
  22. RD Braun, JL Lanzen, SA Snyder, MW Dewhirst, Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents., American journal of physiology. Heart and circulatory physiology, United States, vol. 280 no. 6 (June, 2001), pp. H2533-44  [abs].
  23. DE Meyer, BC Shin, GA Kong, MW Dewhirst, A Chilkoti, Drug targeting using thermally responsive polymers and local hyperthermia., Journal of controlled release : official journal of the Controlled Release Society, Netherlands, vol. 74 no. 1-3 (July, 2001), pp. 213-24  [abs].
  24. F Lohr, DY Lo, DA Zaharoff, K Hu, X Zhang, Y Li, Y Zhao, MW Dewhirst, F Yuan, CY Li, Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation., Cancer research, United States, vol. 61 no. 8 (April, 2001), pp. 3281-4  [abs].
  25. RD Braun, JL Lanzen, JA Turnage, G Rosner, MW Dewhirst, Effects of the interaction between carbogen and nicotinamide on R3230 Ac tumor blood flow in Fischer 344 rats., Radiation research, United States, vol. 155 no. 5 (May, 2001), pp. 724-33  [abs].
  26. DM Brizel, T Schroeder, RL Scher, S Walenta, RW Clough, MW Dewhirst, W Mueller-Klieser, Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer., International journal of radiation oncology, biology, physics, United States, vol. 51 no. 2 (October, 2001), pp. 349-53  [abs].
  27. M Neeman, H Dafni, O Bukhari, RD Braun, MW Dewhirst, In vivo BOLD contrast MRI mapping of subcutaneous vascular function and maturation: validation by intravital microscopy., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 45 no. 5 (May, 2001), pp. 887-98  [abs].
  28. M Neeman, JM Provenzale, MW Dewhirst, Magnetic resonance imaging applications in the evaluation of tumor angiogenesis., Seminars in radiation oncology, UNITED STATES, vol. 11 no. 1 (January, 2001), pp. 70-82  [abs].
  29. GM Tozer, VE Prise, J Wilson, M Cemazar, S Shan, MW Dewhirst, PR Barber, B Vojnovic, DJ Chaplin, Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability., Cancer research, United States, vol. 61 no. 17 (September, 2001), pp. 6413-22  [abs].
  30. CY Li, JB Little, K Hu, W Zhang, L Zhang, MW Dewhirst, Q Huang, Persistent genetic instability in cancer cells induced by non-DNA-damaging stress exposures., Cancer research, United States, vol. 61 no. 2 (January, 2001), pp. 428-32  [abs].
  31. Z Vujaskovic, MS Anscher, QF Feng, ZN Rabbani, K Amin, TS Samulski, MW Dewhirst, ZA Haroon, Radiation-induced hypoxia may perpetuate late normal tissue injury., International journal of radiation oncology, biology, physics, United States, vol. 50 no. 4 (July, 2001), pp. 851-5  [abs].
  32. SA Snyder, JL Lanzen, RD Braun, G Rosner, TW Secomb, J Biaglow, DM Brizel, MW Dewhirst, Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone., International journal of radiation oncology, biology, physics, United States, vol. 51 no. 2 (October, 2001), pp. 494-506  [abs].
  33. F Lohr, Q Huang, K Hu, MW Dewhirst, CY Li, Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors., Clinical cancer research : an official journal of the American Association for Cancer Research, United States, vol. 7 no. 11 (November, 2001), pp. 3625-8  [abs].
  34. DE Meyer, GA Kong, MW Dewhirst, MR Zalutsky, A Chilkoti, Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia., Cancer research, United States, vol. 61 no. 4 (February, 2001), pp. 1548-54  [abs].
  35. D Needham, MW Dewhirst, The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors., Advanced drug delivery reviews, Netherlands, vol. 53 no. 3 (December, 2001), pp. 285-305  [abs].
  36. S Shan, AC Lockhart, WY Saito, AM Knapp, KR Laderoute, MW Dewhirst, The novel tubulin-binding drug BTO-956 inhibits R3230AC mammary carcinoma growth and angiogenesis in Fischer 344 rats., Clinical cancer research : an official journal of the American Association for Cancer Research, United States, vol. 7 no. 8 (August, 2001), pp. 2590-6  [abs].
  37. S Walenta, S Snyder, ZA Haroon, RD Braun, K Amin, D Brizel, W Mueller-Klieser, B Chance, MW Dewhirst, Tissue gradients of energy metabolites mirror oxygen tension gradients in a rat mammary carcinoma model., International journal of radiation oncology, biology, physics, United States, vol. 51 no. 3 (November, 2001), pp. 840-8  [abs].
  38. A Lal, H Peters, B St Croix, ZA Haroon, MW Dewhirst, RL Strausberg, JH Kaanders, AJ van der Kogel, GJ Riggins, Transcriptional response to hypoxia in human tumors., Journal of the National Cancer Institute, United States, vol. 93 no. 17 (September, 2001), pp. 1337-43  [abs].
  39. SN Ettinger, CC Poellmann, NA Wisniewski, AA Gaskin, JS Shoemaker, JM Poulson, MW Dewhirst, B Klitzman, Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis., Cancer research, United States, vol. 61 no. 21 (November, 2001), pp. 7964-70  [abs].
  40. MW Dewhirst, H Kimura, SW Rehmus, RD Braun, D Papahadjopoulos, K Hong, TW Secomb, Microvascular studies on the origins of perfusion-limited hypoxia., The British journal of cancer. Supplement, ENGLAND, vol. 27 (July, 1996), pp. S247-51  [abs].
  41. DM Brizel, SP Scully, JM Harrelson, LJ Layfield, JM Bean, LR Prosnitz, MW Dewhirst, Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma., Cancer research, UNITED STATES, vol. 56 no. 5 (March, 1996), pp. 941-3  [abs].
  42. H Kimura, NZ Wu, R Dodge, DP Spencer, BM Klitzman, TM McIntyre, MW Dewhirst, Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021., International journal of radiation oncology, biology, physics, UNITED STATES, vol. 33 no. 3 (October, 1995), pp. 627-33  [abs].
  43. HD Sostman, DM Prescott, MW Dewhirst, RK Dodge, DE Thrall, RL Page, JA Tucker, JM Harrelson, G Reece, KA Leopold, MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas., Radiology, UNITED STATES, vol. 190 no. 1 (January, 1994), pp. 269-75  [abs].
  44. PD Maguire, TV Samulski, LR Prosnitz, EL Jones, GL Rosner, B Powers, LW Layfield, DM Brizel, SP Scully, JM Harrelson, MW Dewhirst, A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy., International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, England, vol. 17 no. 4 , pp. 283-90  [abs].
  45. ZA Haroon, K Amin, W Saito, W Wilson, CS Greenberg, MW Dewhirst, SU5416 delays wound healing through inhibition of TGF-beta 1 activation., Cancer biology & therapy, United States, vol. 1 no. 2 , pp. 121-6  [abs].
Biomedical Engineering Department
Pratt School of Engineering | Duke University
Room 136 Hudson Hall • Box 90281 • Durham, NC 27708-0281
Phone: (919) 660-5131 • Fax: (919) 684-4488