G. Allan Johnson, Professor of Radiology, Diagnostic Physics and Biomedical Engineering  


G. Allan Johnson
Contact Info:
Office Location:  141D Bryan Research Building for Neurobiology
Office Phone:  (919) 684-7754, (919) 684-7755
Email Address:   send me a message
Web Page: http://www.civm.duhs.duke.edu/

Education:

Ph.D., Duke University, 1974
Research Interests: Medical Physics

Dr. Johnson's research involves magnetic resonance histology (MRH), the application of MR microscopy to study tissue architecture. Using MRH for morphologic phenotyping in the mouse was first suggested by Dr. Johnson and his colleagues in this article (Radiology 2002;222:789 –793 2002). A publication of our Waxholm Space (WHS) atlas of the C57BL mouse brain was created in conjunction with the International Neuroinformatics Coordinating Facility (INCF) digital brain atlasing program (http://software.incf.org/software/waxholm-space) to be the center of a digital atlasing architecture to share mouse brain data with the scientific research community.

Areas of Interest:

magnetic resonance histology
magnetic resonance imaging
small animal imaging

Specialties:

Medical Imaging
Representative Publications   (More Publications)   (search)

  1. Calabrese, E; Johnson, GA, Diffusion tensor magnetic resonance histology reveals microstructural changes in the developing rat brain., Neuroimage, vol. 79 (October, 2013), pp. 329-339 [23648962], [doi]  [abs].
  2. Calabrese, E; Badea, A; Watson, C; Johnson, GA, A quantitative magnetic resonance histology atlas of postnatal rat brain development with regional estimates of growth and variability., Neuroimage, vol. 71 (May, 2013), pp. 196-206 [23353030], [doi]  [abs].
  3. Antonsen, BT; Jiang, Y; Veraart, J; Qu, H; Nguyen, HP; Sijbers, J; von Hörsten, S; Johnson, GA; Leergaard, TB, Altered diffusion tensor imaging measurements in aged transgenic Huntington disease rats., Brain Struct Funct, vol. 218 no. 3 (May, 2013), pp. 767-778 [doi]  [abs].
  4. Calabrese, E; Johnson, GA; Watson, C, An ontology-based segmentation scheme for tracking postnatal changes in the developing rodent brain with MRI., Neuroimage, vol. 67 (February, 2013), pp. 375-384 [23246176], [doi]  [abs].
  5. Liu, C; Li, W; Wu, B; Jiang, Y; Johnson, GA, 3D fiber tractography with susceptibility tensor imaging., Neuroimage, vol. 59 no. 2 (January, 2012), pp. 1290-1298 [21867759], [doi]  [abs].
  6. Badea, A; Johnson, GA, Magnetic resonance microscopy., in Medical Imaging: Principles and Practices, Anal Cell Pathol (Amst), vol. 35 no. 4 (2012), pp. 205-227, IOS Press Ebooks [22142643], [doi]  [abs].
  7. Veraart, J; Leergaard, TB; Antonsen, BT; Van Hecke, W; Blockx, I; Jeurissen, B; Jiang, Y; Van der Linden, A; Johnson, GA; Verhoye, M; Sijbers, J, Population-averaged diffusion tensor imaging atlas of the Sprague Dawley rat brain., Neuroimage, vol. 58 no. 4 (October, 2011), pp. 975-983 [21749925], [doi]  [abs].
  8. Jiang, Y; Johnson, GA, Microscopic diffusion tensor atlas of the mouse brain., Neuroimage, vol. 56 no. 3 (June, 2011), pp. 1235-1243 [21419226], [doi]  [abs].
  9. Bowden, DM; Johnson, GA; Zaborsky, L; Green, WDK; Moore, E; Badea, A; Dubach, MF; Bookstein, FL, A symmetrical Waxholm canonical mouse brain for NeuroMaps., J Neurosci Methods, vol. 195 no. 2 (February, 2011), pp. 170-175 [21163300], [doi]  [abs].
  10. Hawrylycz, M; Baldock, RA; Burger, A; Hashikawa, T; Johnson, GA; Martone, M; Ng, L; Lau, C; Larson, SD; Nissanov, J; Puelles, L; Ruffins, S; Verbeek, F; Zaslavsky, I; Boline, J, Digital atlasing and standardization in the mouse brain., PLoS Comput Biol, vol. 7 no. 2 (February, 2011), pp. e1001065 [21304938], [doi] .
  11. Pandit, P; Qi, Y; King, KF; Johnson, GA, Reduction of artifacts in T2 -weighted PROPELLER in high-field preclinical imaging., Magn Reson Med, vol. 65 no. 2 (February, 2011), pp. 538-543 [20928875], [doi]  [abs].
  12. Johnson, GA; Badea, A; Brandenburg, J; Cofer, G; Fubara, B; Liu, S; Nissanov, J, Waxholm space: an image-based reference for coordinating mouse brain research., Neuroimage, vol. 53 no. 2 (November, 2010), pp. 365-372 [20600960], [doi]  [abs].
  13. O'Leary-Moore, SK; Parnell, SE; Godin, EA; Dehart, DB; Ament, JJ; Khan, AA; Johnson, GA; Styner, MA; Sulik, KK, Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice., Birth Defects Res A Clin Mol Teratol, vol. 88 no. 11 (November, 2010), pp. 953-964 [20842647], [doi]  [abs].
  14. Howles, GP; Bing, KF; Qi, Y; Rosenzweig, SJ; Nightingale, KR; Johnson, GA, Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound., Magn Reson Med, vol. 64 no. 4 (October, 2010), pp. 995-1004 [20740666], [doi]  [abs].
  15. Pandit, P; Qi, Y; Story, J; King, KF; Johnson, GA, Multishot PROPELLER for high-field preclinical MRI., Magn Reson Med, vol. 64 no. 1 (July, 2010), pp. 47-53 [20572138], [doi]  [abs].
  16. Howles, GP; Qi, Y; Johnson, GA, Ultrasonic disruption of the blood-brain barrier enables in vivo functional mapping of the mouse barrel field cortex with manganese-enhanced MRI., Neuroimage, vol. 50 no. 4 (May, 2010), pp. 1464-1471 [20096789], [doi]  [abs].
  17. Bucholz, E; Ghaghada, K; Qi, Y; Mukundan, S; Rockman, HA; Johnson, GA, Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA., Magn Reson Med, vol. 63 no. 4 (April, 2010), pp. 979-987 [20373399], [doi]  [abs].
  18. Badea, A; Johnson, GA; Jankowsky, JL, Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease., Neuroimage, vol. 50 no. 2 (April, 2010), pp. 416-427 [20035883], [doi]  [abs].
  19. Jiang, Y; Johnson, GA, Microscopic diffusion tensor imaging of the mouse brain., Neuroimage, vol. 50 no. 2 (April, 2010), pp. 465-471 [20034583], [doi]  [abs].
  20. Mistry, NN; Qi, Y; Hedlund, LW; Johnson, GA, Ventilation/perfusion imaging in a rat model of airway obstruction., Magn Reson Med, vol. 63 no. 3 (March, 2010), pp. 728-735 [20146375], [doi]  [abs].
  21. Petiet, A; Johnson, GA, Active staining of mouse embryos for magnetic resonance microscopy., Methods Mol Biol, vol. 611 (2010), pp. 141-149 [19960328], [doi]  [abs].
  22. Badea, A; Johnson, GA; Williams, RW, Genetic dissection of the mouse CNS using magnetic resonance microscopy., Curr Opin Neurol, vol. 22 no. 4 (August, 2009), pp. 379-386 [19542887], [doi]  [abs].
  23. Howles, GP; Nouls, JC; Qi, Y; Johnson, GA, Rapid production of specialized animal handling devices using computer-aided design and solid freeform fabrication., J Magn Reson Imaging, vol. 30 no. 2 (August, 2009), pp. 466-471 [19629999], [doi]  [abs].
  24. Badea, A; Johnson, GA; Williams, RW, Genetic dissection of the mouse brain using high-field magnetic resonance microscopy., Neuroimage, vol. 45 no. 4 (May, 2009), pp. 1067-1079 [19349225], [doi]  [abs].
  25. Petiet, AE; Kaufman, MH; Goddeeris, MM; Brandenburg, J; Elmore, SA; Johnson, GA, High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database., Proc Natl Acad Sci U S A, vol. 105 no. 34 (August, 2008), pp. 12331-12336 [18713865], [doi]  [abs].
  26. Bucholz, E; Ghaghada, K; Qi, Y; Mukundan, S; Johnson, GA, Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent., Magn Reson Med, vol. 60 no. 1 (July, 2008), pp. 111-118 [18581419], [doi]  [abs].
  27. Goddeeris, MM; Rho, S; Petiet, A; Davenport, CL; Johnson, GA; Meyers, EN; Klingensmith, J, Intracardiac septation requires hedgehog-dependent cellular contributions from outside the heart., Development, vol. 135 no. 10 (May, 2008), pp. 1887-1895 [18441277], [doi]  [abs].
  28. Nouls, JC; Izenson, MG; Greeley, HP; Johnson, GA, Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain., J Magn Reson, vol. 191 no. 2 (April, 2008), pp. 231-238 [18221901], [doi]  [abs].
  29. Badea, A; Ali-Sharief, AA; Johnson, GA, Morphometric analysis of the C57BL/6J mouse brain., Neuroimage, vol. 37 no. 3 (September, 2007), pp. 683-693 [17627846], [doi]  [abs].
  30. Johnson, GA; Ali-Sharief, A; Badea, A; Brandenburg, J; Cofer, G; Fubara, B; Gewalt, S; Hedlund, LW; Upchurch, L, High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology., Neuroimage, vol. 37 no. 1 (August, 2007), pp. 82-89 [17574443], [doi]  [abs].
  31. Petiet, A; Hedlund, L; Johnson, GA, Staining methods for magnetic resonance microscopy of the rat fetus., J Magn Reson Imaging, vol. 25 no. 6 (June, 2007), pp. 1192-1198 [17520739], [doi]  [abs].
  32. Nahrendorf, M; Badea, C; Hedlund, LW; Figueiredo, J-L; Sosnovik, DE; Johnson, GA; Weissleder, R, High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT., Am J Physiol Heart Circ Physiol, vol. 292 no. 6 (June, 2007), pp. H3172-H3178 [17322414], [doi]  [abs].
  33. Badea, A; Nicholls, PJ; Johnson, GA; Wetsel, WC, Neuroanatomical phenotypes in the reeler mouse., Neuroimage, vol. 34 no. 4 (February, 2007), pp. 1363-1374 [17185001], [doi]  [abs].
  34. Mistry, N; De Lin, M; Hedlund, L; Johnson, GA, Multimodality imaging of pulmonary function in the rodent, 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings, vol. 2006 (November, 2006), pp. 920-923  [abs].
  35. Sharief, AA; Johnson, GA, Enhanced T2 contrast for MR histology of the mouse brain., Magn Reson Med, vol. 56 no. 4 (October, 2006), pp. 717-725 [16964618], [doi]  [abs].
  36. AA Sharief, GA Johnson, Enhanced T2 contrast for MR histology of the mouse brain., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 56 no. 4 (October, 2006), pp. 717-25  [abs].
  37. Mukundan, S; Ghaghada, KB; Badea, CT; Kao, C-Y; Hedlund, LW; Provenzale, JM; Johnson, GA; Chen, E; Bellamkonda, RV; Annapragada, A, A liposomal nanoscale contrast agent for preclinical CT in mice., AJR Am J Roentgenol, vol. 186 no. 2 (February, 2006), pp. 300-307 [16423931], [doi]  [abs].
  38. Badea, CT; Bucholz, E; Hedlund, LW; Rockman, HA; Johnson, GA, Imaging methods for morphological and functional phenotyping of the rodent heart., Toxicol Pathol, vol. 34 no. 1 (2006), pp. 111-117 [16507552], [doi]  [abs].
  39. Badea, CT; Hedlund, LW; De Lin, M; Boslego Mackel, JF; Johnson, GA, Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents., Contrast Media Mol Imaging, vol. 1 no. 4 (2006), pp. 153-164 [17193692], [doi]  [abs].
  40. Ali, AA; Dale, AM; Badea, A; Johnson, GA, Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain., Neuroimage, vol. 27 no. 2 (August, 2005), pp. 425-435 [15908233], [doi]  [abs].
  41. M Cyr, MG Caron, GA Johnson, A Laakso, Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction., NeuroImage, United States, vol. 26 no. 1 (May, 2005), pp. 83-90  [abs].
  42. Mai, W. and Badea, C.T. and Wheeler, C.T. and Hedlund, L.W. and Johnson, G.A., Effects of breathing and cardiac motion on spatial resolution in the microscopic imaging of rodents, Magn. Reson. Med. (USA), vol. 53 no. 4 (2005), pp. 858 - 65 [mrm.20400]  [abs].
  43. Chen, BT; Brau, ACS; Johnson, GA, Measurement of regional lung function in rats using hyperpolarized 3helium dynamic MRI., Magn Reson Med, vol. 49 no. 1 (January, 2003), pp. 78-88 [12509822], [doi]  [abs].
  44. BT Chen, AC Brau, GA Johnson, Measurement of regional lung function in rats using hyperpolarized 3helium dynamic MRI., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, United States, vol. 49 no. 1 (January, 2003), pp. 78-88  [abs].
  45. Johnson, GA; Cofer, GP; Fubara, B; Gewalt, SL; Hedlund, LW; Maronpot, RR, Magnetic resonance histology for morphologic phenotyping., J Magn Reson Imaging, vol. 16 no. 4 (October, 2002), pp. 423-429 [12353257], [doi]  [abs].
  46. Gareau, PJ; Wymore, AC; Cofer, GP; Johnson, GA, Imaging inflammation: direct visualization of perivascular cuffing in EAE by magnetic resonance microscopy., J Magn Reson Imaging, vol. 16 no. 1 (July, 2002), pp. 28-36 [12112500], [doi]  [abs].
  47. Möller, HE; Chen, XJ; Saam, B; Hagspiel, KD; Johnson, GA; Altes, TA; de Lange, EE; Kauczor, H-U, MRI of the lungs using hyperpolarized noble gases., Magn Reson Med, vol. 47 no. 6 (June, 2002), pp. 1029-1051 [12111949], [doi]  [abs].
  48. Paulson, EK; Yoshizumi, TT; Frush, DP; Johnson, GA, Multi-detector vs single-detector CT: The organ doses are higher than you think, RADIOLOGY, vol. 221 (November, 2001), pp. 403-403, RADIOLOGICAL SOC NORTH AMERICA [Gateway.cgi] .
  49. Hedlund, LW; Cofer, GP; Owen, SJ; Allan Johnson, G, MR-compatible ventilator for small animals: computer-controlled ventilation for proton and noble gas imaging., Magn Reson Imaging, vol. 18 no. 6 (July, 2000), pp. 753-759 [10930785], [doi]  [abs].
  50. L. W. Hedlund and H. E. Moller and X. J. Chen and M. S. Chawla and G. P. Cofer and G. A. Johnson, Mixing oxygen with hyperpolarized He-3 for small-animal lung studies, Nmr In Biomedicine, vol. 13 no. 4 (June, 2000), pp. 202 -- 206 .
  51. Hedlund, LW; Möller, HE; Chen, XJ; Chawla, MS; Cofer, GP; Johnson, GA, Mixing oxygen with hyperpolarized (3)He for small-animal lung studies., NMR Biomed, vol. 13 no. 4 (June, 2000), pp. 202-206 [10867697], [doi]  [abs].
  52. Benveniste, H; Kim, K; Zhang, L; Johnson, GA, Magnetic resonance microscopy of the C57BL mouse brain., Neuroimage, vol. 11 no. 6 Pt 1 (June, 2000), pp. 601-611 [Gateway.cgi], [doi]  [abs].
  53. Lester, DS; Pine, PS; Delnomdedieu, M; Johannessen, JN; Johnson, GA, Virtual neuropathology: three-dimensional visualization of lesions due to toxic insult., Toxicol Pathol, vol. 28 no. 1 (2000), pp. 100-104 [doi]  [abs].
  54. X. J. Chen and H. E. Moller and M. S. Chawla and G. P. Cofer and B. Driehuys and L. W. Hedlund and J. R. Macfall and G. A. Johnson, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T-2*, Magnetic Resonance In Medicine, vol. 42 no. 4 (October, 1999), pp. 729 -- 737 .
  55. Chen, XJ; Möller, HE; Chawla, MS; Cofer, GP; Driehuys, B; Hedlund, LW; Johnson, GA, Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient., Magn Reson Med, vol. 42 no. 4 (October, 1999), pp. 721-728 [10502761], [doi]  [abs].
  56. Benveniste, HD; Kim, KR; Hedlund, LW; Johnson, GA; Friedman, AH, Cerebral hemorrhage and edema following brain biopsy in rats: Significance of mean arterial blood pressure, ANESTHESIOLOGY, vol. 91 no. 3A (September, 1999), pp. U371-U371, LIPPINCOTT WILLIAMS & WILKINS [Gateway.cgi] .
  57. Lester, DS; Lyon, RC; McGregor, GN; Engelhardt, RT; Schmued, LC; Johnson, GA; Johannessen, JN, 3-Dimensional visualization of lesions in rat brain using magnetic resonance imaging microscopy., Neuroreport, vol. 10 no. 4 (March, 1999), pp. 737-741 [10208540], [doi]  [abs].
  58. Chen, XJ; Chawla, MS; Cofer, GP; Hedlund, LW; Möller, HE; Johnson, GA, Hyperpolarized 3He NMR lineshape measurements in the live guinea pig lung., Magn Reson Med, vol. 40 no. 1 (July, 1998), pp. 61-65 [9660554], [doi]  [abs].
  59. Hurlston SE, Brey WW, Suddarth SA, Yap M, Johson GA. A high temperature superconducting Helmholtz probe for microscopy at 9.4 T Magn Res Med. In press 1998 .
  60. Engelhardt, RT; Johnson, GA, T1 rho relaxation and its application to MR histology., Magn Reson Med, vol. 35 no. 5 (May, 1996), pp. 781-786 [8722830], [doi]  [abs].
  61. RT Engelhardt, GA Johnson, T1 rho relaxation and its application to MR histology., Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, UNITED STATES, vol. 35 no. 5 (May, 1996), pp. 781-6  [abs].
  62. Johnson, GA; Benveniste, H; Black, RD; Hedlund, LW; Maronpot, RR; Smith, BR, Histology by magnetic resonance microscopy., Magn Reson Q, vol. 9 no. 1 (March, 1993), pp. 1-30 [8512830]  [abs].
  63. GA Johnson, H Benveniste, RD Black, LW Hedlund, RR Maronpot, BR Smith, Histology by magnetic resonance microscopy., Magnetic resonance quarterly, UNITED STATES, vol. 9 no. 1 (March, 1993), pp. 1-30  [abs].
  64. Hedlund, L; Cofer, G; Suddarth, S; Johnson, GA, 177. SMALL ANIMAL ANESTHESIA AND MONITORING DURING EXTENDED MR MICROSCOPY, Investigative Radiology, vol. 22 no. 9 (September, 1987), pp. S44-S44, Ovid Technologies (Wolters Kluwer Health) [Gateway.cgi], [doi] .