Papers Published

1. Rollins, A.M. and Yazdanfar, S. and Barton, J.K. and Izatt, J.A., Real-time in vivo color Doppler optical coherence tomography, J. Biomed. Opt. (USA), vol. 7 no. 1 (2002), pp. 123 - 9 [1.1428291] .
   (last updated on 2007/04/13)

   Abstract:
   Color Doppler optical coherence tomography (CDOCT) is a functional extension of optical coherence tomography (OCT) that can image flow in turbid media. We have developed a CDOCT system capable of imaging flow in real time. Doppler processing of the analog signal is accomplished in hardware in the time domain using a novel autocorrelation technique. This Doppler processing method is compatible with a high speed OCT system capable of imaging in real time. Using this system, we demonstrate cross-sectional imaging of bidirectional flow with CDOCT at four frames per second in a tissue-simulating phantom consisting of intralipid solution flowing in glass capillaries. As a demonstration of real-time imaging of blood flow in vivo we imaged pulsatible blood flow in a rat femoral artery at eight frames per second. Issues of velocity sensitivity, imaging speed, and range of velocity measurement are discussed, as well as potential applications of real-time CDOCT

   Keywords:
   blood flow measurement;blood vessels;Doppler measurement;optical tomography;pulsatile flow;real-time systems;turbidity;